Publications by authors named "Aaron D Schimmer"

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Very long chain fatty acid metabolism is required in acute myeloid leukemia.
Matthew Tcheng, Alessia Roma, Nawaz Ahmed, Richard W Smith, Preethi Jayanth, Mark D Minden, Aaron D Schimmer, David A Hess, Kristin Hope, Kevin A Rea

Blood· June 2021

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Real-world experience with CPX-351 for secondary acute myeloid leukaemia: Comparison with FLAG-IDA in a propensity score matching analysis.
Maria Agustina Perusini, Ana Flavia Patiño, Claire Andrews, Sarit E Assouline, Joseph M Brandwein, Aaron D Schimmer

Br J Haematol· December 2025

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Enasidenib plus venetoclax in patients with IDH2-mutated relapsed or refractory acute myeloid leukaemia or myelodysplastic syndrome (ENAVEN-AML): a multicentre, single-arm, phase 1b/2 trial.
Guillaume Richard-Carpentier, Gopila Gupta, Charina Koraksic, Severine Cathelin, Lisa Wang, Aaron D Schimmer

Lancet Haematol· November 2025

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A qualitative study of Emotion and Symptom-focused Engagement (EASE): An integrated psychotherapeutic and early palliative care intervention for patients with acute leukemia.
Kathryn Hunt, Laura Foran, Carmine Malfitano, Anne Rydall, Stephanie Nanos, Aaron D Schimmer

Support Care Cancer· November 2025

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Who truly benefits from gilteritinib combinations in FLT3-mutated relapsed-refractory(R/R) AML: a Canadian single center analysis.
Akhil Rajendra, Elliot Smith, Maria Agustina Perusini, Kenny Tang, Eshetu G Atenafu, Aaron D Schimmer

Blood Cancer J· August 2025

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Real-world validation study of the LSC17 score for risk prediction in patients with newly diagnosed acute myeloid leukemia.
Tracy Murphy, Boyang Zhang, Tong Zhang, Ian King, Jose-Mario Capo-Chichi, Aaron D Schimmer

Haematologica· July 2025

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Metformin reduces the competitive advantage of Dnmt3a HSPCs.
Mohsen Hosseini, Veronique Voisin, Ali Chegini, Angelica Varesi, Severine Cathelin, Aaron D Schimmer

Nature· June 2025

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SOCS1 Protects Acute Myeloid Leukemia against Allogeneic T Cell-Mediated Cytotoxicity.
Enoch Tin, Sergio Rutella, Ismat Khatri, Yoosu Na, Yongran Yan, Aaron D Schimmer

Blood Cancer Discov· May 2025

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Randomized phase 2 study to assess the role of single-agent nivolumab to maintain remission in acute myeloid leukemia.
Athalia R Pyzer, Laura W Dillon, Elad Sharon, Theodore G Karrison, Yuanyuan Zha, Aaron D Schimmer

Blood Adv· May 2025

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Acute myeloid leukemia drug-tolerant persister cells survive chemotherapy by transiently increasing plasma membrane rigidity, that also increases their sensitivity to immune cell killing.
Yael Morgenstern, JongBok Lee, Yoosu Na, Brandon Y Lieng, Nicholas S Ly, Aaron D Schimmer

Haematologica· April 2025

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Acute myeloid leukemia mitochondria hydrolyze ATP to support oxidative metabolism and resist chemotherapy.
James T Hagen, McLane M Montgomery, Raphael T Aruleba, Brett R Chrest, Polina Krassovskaia, Aaron D Schimmer

Sci Adv· April 2025

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Mechanism of allosteric activation in human mitochondrial ClpP protease.
Monica M Goncalves, Adwaith B Uday, Taylor J B Forrester, S Quinn W Currie, Angelina S Kim, Aaron D Schimmer

Proc Natl Acad Sci U S A· April 2025

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Elevated mitochondrial membrane potential is a therapeutic vulnerability in Dnmt3a-mutant clonal hematopoiesis.
Kira A Young, Mohsen Hosseini, Jayna J Mistry, Claudia Morganti, Taylor S Mills, Aaron D Schimmer

Nat Commun· April 2025

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Serine phosphorylation facilitates protein degradation by the human mitochondrial ClpXP protease.
Yue Feng, Monica M Goncalves, Yulia Jitkova, Alexander F A Keszei, Yongran Yan, Aaron D Schimmer

Proc Natl Acad Sci U S A· February 2025

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The future of scientific research-centralized expertise and specialization through full-service core facilities.
James Jonkman, Troy Ketela, Nhu-An Pham, Nikolina Radulovich, Genevieve Gasmi-Seabrook, Aaron D Schimmer

Biochem Cell Biol· January 2025

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Outcomes and adverse events in older acute lymphoblastic Leukemia patients treated with a pediatric-inspired protocol with Pegylated or native Asparaginase.
Maria Agustina Perusini, Claire Andrews, Eshetu G Atenafu, Vikas Gupta, Dawn Maze, Aaron D Schimmer

Hematology· December 2024

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Outcome of adolescents and young adult acute myeloid leukemia patients compared with middle-aged patients: A single centre retrospective experience.
RuiQi Chen, Mohaned AlHumaid, Georgina Daher-Reyes, Eshetu G Atenafu, Steven Chan, Aaron D Schimmer

Leuk Res· December 2024

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Acute myeloid leukemia mitochondria hydrolyze ATP to resist chemotherapy.
James T Hagen, Mclane M Montgomery, Raphael T Aruleba, Brett R Chrest, Thomas D Green, Aaron D Schimmer

bioRxiv· November 2024

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Genomic profiles and outcomes in de novo versus therapy-related core binding factor AML.
May Chiu, Aaron D Schimmer, Andre C Schuh, Aniket Bankar, Guillaume Richard-Carpentier

Blood Cancer J· October 2024

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The Imipridone ONC213 Targets α-Ketoglutarate Dehydrogenase to Induce Mitochondrial Stress and Suppress Oxidative Phosphorylation in Acute Myeloid Leukemia.
Yongwei Su, Jenna L Carter, Xinyu Li, Yu Fukuda, Ashley Gray, Aaron D Schimmer

Cancer Res· April 2024

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Venetoclax resistance in acute myeloid leukaemia-Clinical and biological insights.
Boaz Nachmias, Shlomzion Aumann, Arnon Haran, Aaron D Schimmer

Br J Haematol· April 2024

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The proteomic landscape of genotoxic stress-induced micronuclei.
Kate M MacDonald, Shahbaz Khan, Brian Lin, Rose Hurren, Aaron D Schimmer

Mol Cell· April 2024

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Asparaginase completion among adults including older patients with acute lymphoblastic leukemia treated with a modified DFCI protocol.
Maria Agustina Perusini, Claire Andrews, Atenafu G Eshetu, Vikas Gupta, Dawn Maze, Aaron D Schimmer

Leukemia· April 2024

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Correction: Mitochondrial regulation of GPX4 inhibition-mediated ferroptosis in acute myeloid leukemia.
Hiroki Akiyama, Ran Zhao, Lauren B Ostermann, Ziyi Li, Matthew Tcheng, Aaron D Schimmer

Leukemia· April 2024

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Outcomes of intensive and nonintensive blast-reduction strategies in accelerated and blast-phase MPN.
Marta B Davidson, James A Kennedy, Jose-Mario Capo-Chichi, Yuliang Shi, Wei Xu, Aaron D Schimmer

Blood Adv· March 2024

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Metformin reduces the clonal fitness of hematopoietic stem and progenitor cells by reversing their aberrant metabolic and epigenetic state.
Mohsen Hosseini, Veronique Voisin, Ali Chegini, Angelica Varesi, Severine Cathelin, Aaron D Schimmer

Res Sq· February 2024

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