Publications by authors named "Adam Offenbacher"

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Biochemical Consequences of a Leucine-to-Cysteine Clamp Substitution in Lipoxygenases.
Samuel G Hill, Katherine DeFeo, Adam R Offenbacher

Biomolecules· August 2025

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Substitution of the mononuclear, non-heme iron cofactor in lipoxygenases for structural studies.
Andrew Jakobowski, S Gage Hill, S Wyatt Guy, Adam R Offenbacher

Methods Enzymol· September 2024

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Impact of -Glycosylation on Protein Structure and Dynamics Linked to Enzymatic C-H Activation in the Lipoxygenase.
Chris Whittington, Ajay Sharma, S Gage Hill, Anthony T Iavarone, Brian M Hoffman, Adam R Offenbacher

Biochemistry· May 2024

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Identification of the Thermal Activation Network in Human 15-Lipoxygenase-2: Divergence from Plant Orthologs and Its Relationship to Hydrogen Tunneling Activation Barriers.
Amanda Ohler, Paris E Taylor, Jasmine A Bledsoe, Anthony T Iavarone, Nathaniel C Gilbert, Adam R Offenbacher

ACS Catal· April 2024

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Effect of solvent viscosity on the activation barrier of hydrogen tunneling in the lipoxygenase reaction.
Luis Guevara, Melissa Gouge, Amanda Ohler, S Gage Hill, Soham Patel, Adam R Offenbacher

Arch Biochem Biophys· October 2023

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Investigating membrane-binding properties of lipoxygenases using surface plasmon resonance.
Denise L Rohlik, Ethan Patel, Nathaniel C Gilbert, Adam R Offenbacher, Brandon L Garcia

Biochem Biophys Res Commun· August 2023

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Systematic mapping of the conformational landscape and dynamism of soluble fibrinogen.
Jose E E Pinelo, Pragya Manandhar, Grega Popovic, Katherine Ray, Mehmet F Tasdelen, Adam R Offenbacher

J Thromb Haemost· June 2023

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C Electron Nuclear Double Resonance Spectroscopy-Guided Molecular Dynamics Computations Reveal the Structure of the Enzyme-Substrate Complex of an Active, -Linked Glycosylated Lipoxygenase.
Ajay Sharma, Chris Whittington, Mohammed Jabed, S Gage Hill, Anastasiia Kostenko, Adam R Offenbacher

Biochemistry· May 2023

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Temporal and spatial resolution of distal protein motions that activate hydrogen tunneling in soybean lipoxygenase.
Jan Paulo T Zaragoza, Adam R Offenbacher, Shenshen Hu, Christine L Gee, Zachary M Firestein

Proc Natl Acad Sci U S A· March 2023

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Biochemical and hydrogen-deuterium exchange studies of the single nucleotide polymorphism Y649C in human platelet 12-lipoxygenase linked to a bleeding disorder.
Michelle Tran, Rachel L Signorelli, Adriana Yamaguchi, Eefie Chen, Michael Holinstat, Adam R Offenbacher

Arch Biochem Biophys· January 2023

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Electrochemical and Structural Study of the Buried Tryptophan in Azurin: Effects of Hydration and Polarity on the Redox Potential of W48.
Kristin Tyson, Chanin B Tangtartharakul, Matthias Zeug, Nathan Findling, Alice Haddy, Adam R Offenbacher

J Phys Chem B· January 2023

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Membrane-Mimicking Reverse Micelles for High-Resolution Interfacial Study of Proteins and Membranes.
Courtney L Labrecque, Aubree L Nolan, Angela M Develin, Abdul J Castillo, Adam R Offenbacher

Langmuir· March 2022

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Thermodynamic and biophysical study of fatty acid effector binding to soybean lipoxygenase: implications for allostery driven by helix α2 dynamics.
Daniella E Roberts, Amy M Benton, Claire Fabian-Bayola, Anne M Spuches, Adam R Offenbacher

FEBS Lett· February 2022

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Development of Transient Recombinant Expression and Affinity Chromatography Systems for Human Fibrinogen.
Grega Popovic, Nicholas C Kirby, Taylor C Dement, Kristine M Peterson, Caroline E Daub, Adam R Offenbacher

Int J Mol Sci· January 2022

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Kinetic and structural investigations of novel inhibitors of human epithelial 15-lipoxygenase-2.
Wan-Chen Tsai, Nathan C Gilbert, Amanda Ohler, Michelle Armstrong, Steven Perry, Adam R Offenbacher

Bioorg Med Chem· September 2021

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Ribonucleotide Reductase β2 Subunit Inactivation by Triapine Occurs through Binding of a Triapine-Fe(II) Adduct.
Mohammad S Safiarian, R Atlee Watson, Raquel L Lieberman, Bridgette A Barry, Adam R Offenbacher

J Phys Chem Lett· September 2021

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Detection of Catalytically Linked Conformational Changes in Wild-Type Class Ia Ribonucleotide Reductase Using Reaction-Induced FTIR Spectroscopy.
Ryan Atlee Watson, Adam R Offenbacher, Bridgette A Barry

J Phys Chem B· August 2021

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Synthesis of redox-active fluorinated 5-hydroxytryptophans as molecular reporters for biological electron transfer.
Amanda Ohler, Hanna Long, Kei Ohgo, Kristin Tyson, David Murray, Adam R Offenbacher

Chem Commun (Camb)· March 2021

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Mutagenesis, Hydrogen-Deuterium Exchange, and Molecular Docking Investigations Establish the Dimeric Interface of Human Platelet-Type 12-Lipoxygenase.
Wan-Chen Tsai, Ansari Mukhtar Aleem, Chris Whittington, Wilian A Cortopassi, Chakrapani Kalyanaraman, Adam R Offenbacher

Biochemistry· March 2021

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Fatty Acid Allosteric Regulation of C-H Activation in Plant and Animal Lipoxygenases.
Adam R Offenbacher, Theodore R Holman

Molecules· July 2020

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Impact of Local Electrostatics on the Redox Properties of Tryptophan Radicals in Azurin: Implications for Redox-Active Tryptophans in Proton-Coupled Electron Transfer.
Kristin J Tyson, Amanda N Davis, Jessica L Norris, Libero J Bartolotti, Eli G Hvastkovs, Adam R Offenbacher

J Phys Chem Lett· April 2020

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The Soybean Lipoxygenase-Substrate Complex: Correlation between the Properties of Tunneling-Ready States and ENDOR-Detected Structures of Ground States.
Adam R Offenbacher, Ajay Sharma, Peter E Doan, Judith P Klinman, Brian M Hoffman

Biochemistry· February 2020

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A Proton Wire Mediates Proton Coupled Electron Transfer from Hydroxyurea and Other Hydroxamic Acids to Tyrosyl Radical in Class Ia Ribonucleotide Reductase.
Adam R Offenbacher, Bridgette A Barry

J Phys Chem B· January 2020

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Comparative kinetic isotope effects on first- and second-order rate constants of soybean lipoxygenase variants uncover a substrate-binding network.
Shenshen Hu, Adam R Offenbacher, Edbert D Lu, Judith P Klinman

J Biol Chem· November 2019

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Detecting and Characterizing the Kinetic Activation of Thermal Networks in Proteins: Thermal Transfer from a Distal, Solvent-Exposed Loop to the Active Site in Soybean Lipoxygenase.
Jan Paulo T Zaragoza, Andy Nguy, Natalie Minnetian, Zhenyu Deng, Anthony T Iavarone, Adam R Offenbacher

J Phys Chem B· October 2019

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