Publications by authors named "Adel Azab"

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An annotated clinical image dataset for AI classification of malignant and potentially malignant oral lesions.
Noran Ayman, Fat Heya M Zahran, Yomna Safaa El-Din, Noha Adel Azab

Br Dent J· December 2025

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Cyclic-imide derivative (5e) attenuates hyperglycemia in type 1 diabetic rats by protecting pancreatic cells and enhancing insulin secretion.
Wael A Alanazi, Ali H Alenezi, Doaa M El-Nagar, Mohammed M Alanazi, Mohammed M Almutairi, Adel S El-Azab

Saudi Pharm J· December 2025

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Exploiting COX-2 engagement for amplifying anticancer potential of Quinazoline-triazole conjugates with superior EGFR/VEGFR-2 inhibition.
Marwa I Serag, Abdelrahman Hamdi, Eman E Nasr, Mohamed R Elnagar, Mohamed M Tawfik, Adel S El-Azab

Bioorg Chem· November 2025

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Development and validation of a sensitive and fast bioanalytical LC-MS/MS assay for the quantitation of venetoclax and azacitidine in Rat Plasma: Application to pharmacokinetic study.
Manal El-Gendy, Mohamed Hefnawy, Sarah Alrubia, Abdulaziz Alnasser, Amsha Alsegiani, Adel El-Azab

Anal Biochem· March 2025

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Synthesis, Antitumor Activities, and Apoptosis-Inducing Activities of Schiff's Bases Incorporating Imidazolidine-2,4-dione Scaffold: Molecular Docking Studies and Enzymatic Inhibition Activities.
Fhdah S Alanazi, Hamad M Alkahtani, Alaa A-M Abdel-Aziz, Adel S El-Azab, Hanadi H Asiri

Pharmaceuticals (Basel)· March 2025

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Remarkable utilization of quinazoline-based homosulfonamide for cytotoxic effects with triple kinase inhibition activities: cell cycle analysis and molecular docking profile.
Adel S El-Azab, Alaa A-M Abdel-Aziz, Ahmed H Bakheit, Hamad M Alkahtani, Ahmad J Obaidullah

RSC Adv· January 2025

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Harnessing potential COX-2 engagement for boosting anticancer activity of substituted 2-mercapto-4(3H)-quinazolinones with promising EGFR/VEGFR-2 inhibitory activities.
Abdelrahman Hamdi, Samar S Tawfik, Ahmed R Ali, Wafaa A Ewes, Abdullah Haikal, Adel S El-Azab

Bioorg Chem· December 2024

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Antitumor Activity and Multi-Target Mechanism of Phenolic Schiff Bases Bearing Methanesulfonamide Fragments: Cell Cycle Analysis and a Molecular Modeling Study.
Alaa A-M Abdel-Aziz, Adel S El-Azab, Simone Brogi, Rezk R Ayyad, Ibrahim A Al-Suwaidan

Int J Mol Sci· December 2024

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-Alkylated quinazolin-4(3)-ones as dual EGFR/VEGFR-2 kinases inhibitors: design, synthesis, anticancer evaluation and docking study.
Samar S Tawfik, Abdelrahman Hamdi, Ahmed R Ali, Abdullah A Elgazar, Hamed W El-Shafey, Adel S El-Azab

RSC Adv· August 2024

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Synthesis, enzyme inhibition assay, and molecular modeling study of novel pyrazolines linked to 4-methylsulfonylphenyl scaffold: antitumor activity and cell cycle analysis.
Alaa A-M Abdel-Aziz, Adel S El-Azab, Simone Brogi, Rezk R Ayyad, Hamad M Alkahtani

RSC Adv· July 2024

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Avanafil: A comprehensive drug profile.
Abdulrahman A Al-Majed, Amer AlKhairallah, Mohamed W Attwa, Hamad M Alkahtani, Adel S El-Azab

Profiles Drug Subst Excip Relat Methodol· March 2024

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Ponatinib: A comprehensive drug profile.
Mohamed W Attwa, Hamad M Alkahtani, Adel S El-Azab, Alaa A-M Abdel-Aziz, Ali S Abdelhameed

Profiles Drug Subst Excip Relat Methodol· March 2024

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Design, synthesis, and carbonic anhydrase inhibition activities of Schiff bases incorporating benzenesulfonamide scaffold: Molecular docking application.
Adel S El-Azab, Alaa A-M Abdel-Aziz, Silvia Bua, Alessio Nocentini, Ahmed H Bakheit

Saudi Pharm J· December 2023

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Synthesis of novel spirochromane incorporating Schiff's bases, potential antiproliferative activity, and dual EGFR/HER2 inhibition: Cell cycle analysis and study.
Dina I A Othman, Abdelrahman Hamdi, Walaa M Elhusseiny, Adel S El-Azab, Ahmed H Bakheit

Saudi Pharm J· November 2023

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LC-MS/MS method for the quantitation of decitabine and venetoclax in rat plasma after SPE: Application to pharmacokinetic study.
Abdulaziz I Alnasser, Mohamed M Hefnawy, Abdullah M Al-Hossaini, Yousef A Bin Jardan, Adel S El-Azab

Saudi Pharm J· September 2023

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Trends in monoliths: Packings, stationary phases and nanoparticles.
Mohamed Hefnawy, Manal El-Gendy, Huda Al-Salem, Hanin Marenga, Adel El-Azab

J Chromatogr A· February 2023

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A Liquid Chromatography Tandem Mass Spectrometry Method for the Simultaneous Estimation of the Dopamine Receptor Antagonist LE300 and Its N-methyl Metabolite in Plasma: Application to a Pharmacokinetic Study.
Mohamed M Hefnawy, Mohamed W Attwa, Adeeba A Alzamil, Manal A El-Gendy, Adel S El-Azab

Molecules· February 2023

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Synthesis, antitumor, and apoptosis-inducing activities of novel 5-arylidenethiazolidine-2,4-dione derivatives: Histone deacetylases inhibitory activity and molecular docking study.
Abdelrahman Hamdi, Walaa M Elhusseiny, Dina I A Othman, Abdullah Haikal, Ahmed H Bakheit, Adel S El-Azab

Eur J Med Chem· December 2022

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A Rapid and Sensitive Liquid Chromatography-Tandem Mass Spectrometry Bioanalytical Method for the Quantification of Encorafenib and Binimetinib as a First-Line Treatment for Advanced (Unresectable or Metastatic) Melanoma-Application to a Pharmacokinetic Study.
Mohamed M Hefnawy, Mohammed M Alanazi, Abdullah M Al-Hossaini, Abdulaziz I Alnasser, Adel S El-Azab

Molecules· December 2022

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Synthesis, Cytotoxic Evaluation, and Structure-Activity Relationship of Substituted Quinazolinones as Cyclin-Dependent Kinase 9 Inhibitors.
Hamad M Alkahtani, Amer Alhaj Zen, Ahmad J Obaidullah, Mohammed M Alanazi, Abdulrahman A Almehizia, Adel S El-Azab

Molecules· December 2022

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Carbonic Anhydrase Inhibition Activities of Schiff's Bases Based on Quinazoline-Linked Benzenesulfonamide.
Adel S El-Azab, Alaa A-M Abdel-Aziz, Hazem A Ghabbour, Silvia Bua, Alessio Nocentini

Molecules· November 2022

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Design, synthesis, antitumor, and VEGFR-2 inhibition activities of novel 4-anilino-2-vinyl-quinazolines: Molecular modeling studies.
Abdelrahman Hamdi, Hamed W El-Shafey, Dina I A Othman, Adel S El-Azab, Nawaf A AlSaif

Bioorg Chem· May 2022

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Design, synthesis, and analysis of antiproliferative and apoptosis-inducing activities of nitrile derivatives containing a benzofuran scaffold: EGFR inhibition assay and molecular modelling study.
Salma Fares, Khalid B Selim, Fatma E Goda, Magda A A El-Sayed, Nawaf A AlSaif, Adel S El-Azab

J Enzyme Inhib Med Chem· December 2021

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Synthesis, potential antitumor activity, cell cycle analysis, and multitarget mechanisms of novel hydrazones incorporating a 4-methylsulfonylbenzene scaffold: a molecular docking study.
Alaa A-M Abdel-Aziz, Adel S El-Azab, Nawaf A AlSaif, Ahmad J Obaidullah, Abdulrahman M Al-Obaid

J Enzyme Inhib Med Chem· December 2021

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Co-Inhibition of P-gp and Hsp90 by an Isatin-Derived Compound Contributes to the Increase of the Chemosensitivity of MCF7/ADR-Resistant Cells to Doxorubicin.
Ashraf N Abdalla, Miriana Di Stefano, Giulio Poli, Tiziano Tuccinardi, Ammar Bader, Adel S El-Azab

Molecules· December 2021

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