Publications by authors named "Alexa B Schrock"

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Liquid Biopsy of Lung Cancer Before Pathological Diagnosis Is Associated With Shorter Time to Treatment.
Alessandro Russo, Jessica K Lee, Lincoln W Pasquina, Marzia Del Re, Holli H Dilks, Karthikeyan Murugesan, Russell W Madison, Yi Lee, Alexa B Schrock, Leah Comment

JCO Precis Oncol· January 2024

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Tumor Mutational Burden in Real-World Patients With Pancreatic Cancer: Genomic Alterations and Predictive Value for Immune Checkpoint Inhibitor Effectiveness.
Julia C F Quintanilha, Michael H Storandt, Ryon P Graf, Gerald Li, Rachel Keller, Douglas I Lin, Jeffrey S Ross, Richard S P Huang, Alexa B Schrock, Geoffrey R Oxnard

JCO Precis Oncol· July 2023

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Analytical validation of a homologous recombination deficiency signature (HRDsig) in pan-tumor tissue samples.
Wenshu Li, Jeffrey A Leibowitz, Shuoguo Wang, Louisa Walker, Chang Xu, Alexa B Schrock

PLoS One· November 2025

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Activating Mutations in the MET Kinase Domain Co-Occur With Other Driver Oncogenes and Mediate Resistance to Targeted Therapy in NSCLC.
Seshiru Nakazawa, Federica Pecci, Biagio Ricciuti, Felix H Gottlieb, Francesco Facchinetti, Alexa B Schrock

J Thorac Oncol· August 2025

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Correction: Effectiveness of PARP Inhibitor Maintenance Therapy in Ovarian Cancer by BRCA1/2 and a Scar-Based HRD Signature in Real-World Practice.
Debra L Richardson, Julia C F Quintanilha, Natalie Danziger, Gerald Li, Ethan Sokol, Alexa B Schrock

Clin Cancer Res· August 2025

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LODESTAR: A Single-Arm Phase II Study of Rucaparib in Solid Tumors With Pathogenic Germline or Somatic Variants in Homologous Recombination Repair Genes.
Sriram Anbil, Nicholas J Seewald, E Gabriela Chiorean, Maen Hussein, Pashtoon Murtaza Kasi, Alexa B Schrock

JCO Precis Oncol· July 2025

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Tissue-based genomic profiling of 300,000 tumors highlights the detection of variants with low allele fraction.
Saumya D Sisoudiya, Hanna Tukachinsky, Rachel B Keller-Evans, Alexa B Schrock, Richard S P Huang

NPJ Precis Oncol· June 2025

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Genomic landscape and homologous recombination repair deficiency signature in stage I-III and de novo stage IV primary breast cancers.
June E Jeon, Kuei-Ting Chen, Russell Madison, Alexa B Schrock, Ethan Sokol

Oncologist· May 2025

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Diverse ERBB2/ERBB3 Activating Alterations and Coalterations Have Implications for HER2/3-Targeted Therapies across Solid Tumors.
Dazhi Liu, Justin Jee, Alexander Drilon, Andreas M Heilmann, Justin M Allen, Alexa B Schrock

Cancer Res Commun· April 2025

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Genomic analysis of comprehensive next generation sequencing data to explore the criteria for MET amplification as an actionable biomarker in NSCLC.
David Chun Cheong Tsui, Jessica K Lee, Candice Francheska B Tambaoan, Jason Hughes, Bernard Fendler, Alexa B Schrock

Lung Cancer· January 2025

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Effectiveness of PARP Inhibitor Maintenance Therapy in Ovarian Cancer by BRCA1/2 and a Scar-Based HRD Signature in Real-World Practice.
Debra L Richardson, Julia C F Quintanilha, Natalie Danziger, Gerald Li, Ethan Sokol, Alexa B Schrock

Clin Cancer Res· October 2024

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Real-World Clinical Performance of a DNA-Based Comprehensive Genomic Profiling Assay for Detecting Targetable Fusions in Nonsquamous NSCLC.
Philip C Mack, Rachel B Keller-Evans, Gerald Li, Katherine T Lofgren, Alexa B Schrock

Oncologist· August 2024

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Activating Point Mutations in the MET Kinase Domain Represent a Unique Molecular Subset of Lung Cancer and Other Malignancies Targetable with MET Inhibitors.
Federica Pecci, Seshiru Nakazawa, Biagio Ricciuti, Guilherme Harada, Jessica K Lee, Alexa B Schrock

Cancer Discov· August 2024

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Liquid biopsy-based circulating tumour (ct)DNA analysis of a spectrum of myeloid and lymphoid malignancies yields clinically actionable results.
Douglas A Mata, Jessica K Lee, Vignesh Shanmugam, Chelsea B Marcus, Alexa B Schrock

Histopathology· June 2024

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RAS/RAF Comutation and ERBB2 Copy Number Modulates HER2 Heterogeneity and Responsiveness to HER2-directed Therapy in Colorectal Cancer.
Harshabad Singh, Pranshu Sahgal, Kevin Kapner, Steven M Corsello, Hersh Gupta, Alexa B Schrock

Clin Cancer Res· April 2024

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Association of Timely Comprehensive Genomic Profiling With Precision Oncology Treatment Use and Patient Outcomes in Advanced Non-Small-Cell Lung Cancer.
Jeff Yorio, Katherine T Lofgren, Jessica K Lee, Khaled Tolba, Geoffrey R Oxnard, Alexa B Schrock

JCO Precis Oncol· March 2024

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Real-World Genomic Profile of EGFR Second-Site Mutations and Other Osimertinib Resistance Mechanisms and Clinical Landscape of NSCLC Post-Osimertinib.
Julia K Rotow, Jessica K Lee, Russell W Madison, Geoffrey R Oxnard, Pasi A Jänne, Alexa B Schrock

J Thorac Oncol· February 2024

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The Molecular, Immunologic, and Clinicodemographic Landscape of MYC-Amplified Advanced Prostate Cancer.
Will H Jin, Liangliang Zhang, Ryon Graf, Kira Raskina, Hanna Tukachinsky, Alexa B Schrock

Clin Genitourin Cancer· February 2024

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Circulating Tumor DNA Enables Sensitive Detection of Actionable Gene Fusions and Rearrangements Across Cancer Types.
Pashtoon M Kasi, Jessica K Lee, Lincoln W Pasquina, Brennan Decker, Pierre Vanden Borre, Alexa B Schrock

Clin Cancer Res· February 2024

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Real-World comprehensive genomic profiling data for diagnostic clarity in pulmonary Large-Cell neuroendocrine carcinoma.
Laura Burns, Hanna Tukachinsky, Kira Raskina, Richard S P Huang, Alexa B Schrock

Lung Cancer· February 2024

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Negative Hyperselection of Patients with HER2+ and RAS Wild-Type Metastatic Colorectal Cancer Receiving Dual HER2 Blockade: the PRESSING-HER2 Study.
Giovanni Randon, Yoshiaki Nakamura, Rona Yaeger, Sara Lonardi, Chiara Cremolini, Alexa B Schrock

Clin Cancer Res· January 2024

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Unique Spectrum of Activating BRAF Alterations in Prostate Cancer.
Alex Chehrazi-Raffle, Hanna Tukachinsky, Eamon Toye, Smruthy Sivakumar, Alexa B Schrock

Clin Cancer Res· October 2023

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Pan-Cancer Analysis of Copy-Number Features Identifies Recurrent Signatures and a Homologous Recombination Deficiency Biomarker to Predict Poly (ADP-Ribose) Polymerase Inhibitor Response.
Jay A Moore, Kuei-Ting Chen, Russell Madison, Justin Y Newberg, Zoe Fleischmann, Alexa B Schrock

JCO Precis Oncol· September 2023

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Homologous Recombination Deficiency Landscape of Breast Cancers and Real-World Effectiveness of Poly ADP-Ribose Polymerase Inhibitors in Patients With Somatic /, Germline , or Homologous Recombination Deficiency Signature.
Felipe Batalini, Russell W Madison, Ethan S Sokol, Dexter X Jin, Kuei-Ting Chen, Alexa B Schrock

JCO Precis Oncol· September 2023

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Comprehensive genomic profiling and treatment patterns across ancestries in advanced prostate cancer: a large-scale retrospective analysis.
Smruthy Sivakumar, Jessica K Lee, Jay A Moore, Julia Hopkins, Justin Y Newberg, Alexa B Schrock

Lancet Digit Health· June 2023

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