Publications by authors named "Alexandra Schafer"

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Remdesivir Inhibits SARS-CoV-2 in Human Lung Cells and Chimeric SARS-CoV Expressing the SARS-CoV-2 RNA Polymerase in Mice.
Andrea J Pruijssers, Amelia S George, Alexandra Schäfer, Sarah R Leist, Lisa E Gralinksi, Kenneth H Dinnon, Boyd L Yount, Maria L Agostini, Laura J Stevens, James D Chappell

July 2020

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Computationally designed mRNA-launched protein nanoparticle immunogens elicit protective antibody and T cell responses in mice.
Grace G Hendricks, Lilit Grigoryan, Mary Jane Navarro, Nicholas J Catanzaro, Miranda L Hubbard

Sci Transl Med· October 2025

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HKU5 bat merbecoviruses engage bat and mink ACE2 as entry receptors.
Mia Madel Alfajaro, Emma L Keeler, Ning Li, Nicholas J Catanzaro, I-Ting Teng

Nat Commun· July 2025

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Designed miniproteins potently inhibit and protect against MERS-CoV.
Robert J Ragotte, M Alejandra Tortorici, Nicholas J Catanzaro, Amin Addetia, Brian Coventry

Cell Rep· June 2025

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Nonstabilized SARS-CoV-2 spike mRNA vaccination induces broadly neutralizing antibodies in nonhuman primates.
R Dilshan Malewana, Victoria Stalls, Aaron May, Xiaozhi Lu, David R Martinez

Sci Transl Med· June 2025

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ACE2 from Pipistrellus abramus bats is a receptor for HKU5 coronaviruses.
Nicholas J Catanzaro, Ziyan Wu, Chengcheng Fan, Victoria Jefferson, Anfal Abdelgadir

Nat Commun· May 2025

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Phylogeny-driven design of broadly protective sarbecovirus receptor-binding domain nanoparticle vaccines.
Amin Addetia, Alexandra Schäfer, Kaitlin Sprouse, Adian Valdez, Ashley Taylor

bioRxiv· May 2025

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A small-molecule SARS-CoV-2 inhibitor targeting the membrane protein.
Ellen Van Damme, Pravien Abeywickrema, Yanting Yin, Jiexiong Xie, Sofie Jacobs

Nature· April 2025

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Dysregulation of lung epithelial cell homeostasis and immunity contributes to Middle East respiratory syndrome coronavirus disease severity.
Amy C Sims, Alexandra Schäfer, Kenichi Okuda, Sarah R Leist, Jacob F Kocher

mSphere· February 2025

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MERS-CoV spike vaccine-induced N-terminal domain-specific antibodies are more protective than receptor binding domain-specific antibodies.
Olubukola M Abiona, Nianshuang Wang, Sarah R Leist, Alexandra Schäfer, Adam S Cockrell

iScience· February 2025

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Host genetic diversity contributes to disease outcome in Crimean-Congo hemorrhagic fever virus infection.
Deepashri Rao, Matthew Lewis, Kimberly Meade-White, Carl Shaia, Atsushi Okumura

Npj Viruses· February 2025

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Protein nanoparticle vaccines induce potent neutralizing antibody responses against MERS-CoV.
Cara W Chao, Kaitlin R Sprouse, Marcos C Miranda, Nicholas J Catanzaro, Miranda L Hubbard

Cell Rep· December 2024

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Animal models of Long Covid: A hit-and-run disease.
Alexandra Schäfer, Sarah R Leist, John M Powers, Ralph S Baric

Sci Transl Med· November 2024

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Designed miniproteins potently inhibit and protect against MERS-CoV.
Robert J Ragotte, M Alejandra Tortorici, Nicholas J Catanzaro, Amin Addetia, Brian Coventry

bioRxiv· November 2024

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Structural characterization of human monoclonal antibodies targeting uncommon antigenic sites on spike glycoprotein of SARS-CoV.
Naveenchandra Suryadevara, Nurgun Kose, Sandhya Bangaru, Elad Binshtein, Jennifer Munt

J Clin Invest· November 2024

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ACE2 from bats is a receptor for HKU5 coronaviruses.
Nicholas J Catanzaro, Ziyan Wu, Chengcheng Fan, Alexandra Schäfer, Boyd L Yount

bioRxiv· August 2024

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Sarbecovirus disease susceptibility is conserved across viral and host models.
Sarah R Leist, Alexandra Schäfer, Ellen L Risemberg, Timothy A Bell, Pablo Hock

Virus Res· August 2024

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Computationally designed mRNA-launched protein nanoparticle vaccines.
Grace G Hendricks, Lilit Grigoryan, Mary Jane Navarro, Nicholas J Catanzaro, Miranda L Hubbard

bioRxiv· July 2024

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Genetic loci regulate Sarbecovirus pathogenesis: A comparison across mice and humans.
Alexandra Schäfer, Lisa E Gralinski, Sarah R Leist, Brea K Hampton, Michael A Mooney

Virus Res· June 2024

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mRNA-LNP vaccine-induced CD8 T cells protect mice from lethal SARS-CoV-2 infection in the absence of specific antibodies.
Brian Montoya, Carolina R Melo-Silva, Lingjuan Tang, Samita Kafle, Peter Lidskiy

Mol Ther· June 2024

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A broadly generalizable stabilization strategy for sarbecovirus fusion machinery vaccines.
Jimin Lee, Cameron Stewart, Alexandra Schäfer, Elizabeth M Leaf, Young-Jun Park

Nat Commun· June 2024

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Mapping of susceptibility loci for Ebola virus pathogenesis in mice.
Alexandra Schäfer, Andrea Marzi, Wakako Furuyama, Nicholas J Catanzaro, Cameron Nguyen

Cell Rep· May 2024

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Adjuvant-dependent impact of inactivated SARS-CoV-2 vaccines during heterologous infection by a SARS-related coronavirus.
Jacob A Dillard, Sharon A Taft-Benz, Audrey C Knight, Elizabeth J Anderson, Katia D Pressey

Nat Commun· May 2024

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The oral nucleoside prodrug GS-5245 is efficacious against SARS-CoV-2 and other endemic, epidemic, and enzootic coronaviruses.
David R Martinez, Fernando R Moreira, Nicholas J Catanzaro, Meghan V Diefenbacher, Mark R Zweigart

Sci Transl Med· May 2024

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A compendium of multi-omics data illuminating host responses to lethal human virus infections.
Amie J Eisfeld, Lindsey N Anderson, Shufang Fan, Kevin B Walters, Peter J Halfmann

Sci Data· April 2024

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Protein nanoparticle vaccines induce potent neutralizing antibody responses against MERS-CoV.
Cara W Chao, Kaitlin R Sprouse, Marcos C Miranda, Nicholas J Catanzaro, Miranda L Hubbard

bioRxiv· March 2024

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