Publications by authors named "Alyssa Dantonio"

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An oral SARS-CoV-2 M inhibitor clinical candidate for the treatment of COVID-19.
Dafydd R Owen, Charlotte M N Allerton, Annaliesa S Anderson, Lisa Aschenbrenner, Melissa Avery, Simon Berritt, Britton Boras, Rhonda D Cardin, Anthony Carlo, Karen J Coffman

December 2021

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Discovery of Nirmatrelvir (PF-07321332): A Potent, Orally Active Inhibitor of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS CoV-2) Main Protease.
Jamison B Tuttle, Christophe Allais, Charlotte M N Allerton, Annaliesa S Anderson, Joel T Arcari, Alyssa Dantonio

J Med Chem· April 2025

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A Second-Generation Oral SARS-CoV-2 Main Protease Inhibitor Clinical Candidate for the Treatment of COVID-19.
Charlotte M N Allerton, Joel T Arcari, Lisa M Aschenbrenner, Melissa Avery, Bruce M Bechle, Alyssa Dantonio

J Med Chem· August 2024

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The Metabolism and Disposition of Brepocitinib in Humans and Characterization of the Formation Mechanism of an Aminopyridine Metabolite.
Martin E Dowty, Ruolun Qiu, Alyssa Dantonio, Mark Niosi, Angela Doran

Drug Metab Dispos· June 2024

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Species differences in plasma protein binding of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease inhibitor nirmatrelvir.
Siennah R Greenfield, Heather Eng, Qingyi Yang, Chunyang Guo, Laura Byrnes, Alyssa Dantonio

Xenobiotica· January 2023

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An improved method for cytochrome p450 reaction phenotyping using a sequential qualitative-then-quantitative approach.
Angela C Doran, Alyssa L Dantonio, Gabrielle M Gualtieri, Amanda Balesano, Connor Landers

Drug Metab Dispos· July 2022

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Defining the Selectivity of Chemical Inhibitors Used for Cytochrome P450 Reaction Phenotyping: Overcoming Selectivity Limitations with a Six-Parameter Inhibition Curve-Fitting Approach.
Angela C Doran, Woodrow Burchett, Connor Landers, Gabrielle M Gualtieri, Amanda Balesano, Alyssa L Dantonio

Drug Metab Dispos· July 2022

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Disposition of Nirmatrelvir, an Orally Bioavailable Inhibitor of SARS-CoV-2 3C-Like Protease, across Animals and Humans.
Heather Eng, Alyssa L Dantonio, Eugene P Kadar, R Scott Obach, Li Di

Drug Metab Dispos· May 2022

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Intersystem Extrapolation Factors Are Substrate-Dependent for CYP3A4: Impact on Cytochrome P450 Reaction Phenotyping.
Alyssa L Dantonio, Angela C Doran, R Scott Obach

Drug Metab Dispos· March 2022

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Data Generated by Quantitative Liquid Chromatography-Mass Spectrometry Proteomics Are Only the Start and Not the Endpoint: Optimization of Quantitative Concatemer-Based Measurement of Hepatic Uridine-5'-Diphosphate-Glucuronosyltransferase Enzymes with Reference to Catalytic Activity.
Brahim Achour, Alyssa Dantonio, Mark Niosi, Jonathan J Novak, Zubida M Al-Majdoub

Drug Metab Dispos· June 2018

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Quantitative Characterization of Major Hepatic UDP-Glucuronosyltransferase Enzymes in Human Liver Microsomes: Comparison of Two Proteomic Methods and Correlation with Catalytic Activity.
Brahim Achour, Alyssa Dantonio, Mark Niosi, Jonathan J Novak, John K Fallon

Drug Metab Dispos· October 2017

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