Publications by authors named "Andre Richters"

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Modulating Androgen Receptor-Driven Transcription in Prostate Cancer with Selective CDK9 Inhibitors.
André Richters, Shelby K Doyle, David B Freeman, Christina Lee, Becky S Leifer, Sajjeev Jagannathan, Florian Kabinger, Jošt Vrabič Koren, Nicholas B Struntz, Julie Urgiles

Cell Chem Biol· February 2021

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Targeted degradation of CDK9 potently disrupts the MYC-regulated network.
Mohammed A Toure, Keisuke Motoyama, Yichen Xiang, Julie Urgiles, Florian Kabinger, Andre Richters

Cell Chem Biol· April 2025

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Targeted Degradation of CDK9 Potently Disrupts the MYC Transcriptional Network.
Mohammed A Toure, Keisuke Motoyama, Yichen Xiang, Julie Urgiles, Florian Kabinger, Andre Richters

bioRxiv· May 2024

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Structure-driven approaches and technologies for drug discovery.
André Richters, Sven Hennig

Drug Discov Today Technol· December 2021

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Identification of cancer driver genes based on nucleotide context.
Felix Dietlein, Donate Weghorn, Amaro Taylor-Weiner, André Richters, Brendan Reardon

Nat Genet· February 2020

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An Array-Based Ligand Discovery Platform for Proteins With Short Half-Lives.
Becky S Leifer, Shelby K Doyle, André Richters, Helen L Evans, Angela N Koehler

Methods Enzymol· June 2019

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Targeting protein arginine methyltransferase 5 in disease.
André Richters

Future Med Chem· November 2017

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Systematic Kinase Inhibitor Profiling Identifies CDK9 as a Synthetic Lethal Target in NUT Midline Carcinoma.
Johannes Brägelmann, Marcel A Dammert, Felix Dietlein, Johannes M Heuckmann, Axel Choidas, André Richters

Cell Rep· September 2017

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Phenotypic Identification of a Novel Autophagy Inhibitor Chemotype Targeting Lipid Kinase VPS34.
Lucas Robke, Luca Laraia, Marjorie A Carnero Corrales, Georgios Konstantinidis, Makoto Muroi, André Richters

Angew Chem Int Ed Engl· July 2017

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Drugging the catalytically inactive state of RET kinase in RET-rearranged tumors.
Dennis Plenker, Maximilian Riedel, Johannes Brägelmann, Marcel A Dammert, Rakhee Chauhan, André Richters

Sci Transl Med· June 2017

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Epigenetic Modulation Using Small Molecules - Targeting Histone Acetyltransferases in Disease.
Andre Richters, Angela N Koehler

Curr Med Chem· January 2017

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A cascade screening approach for the identification of Bcr-Abl myristate pocket binders active against wild type and T315I mutant.
Marco Radi, Ralf Schneider, Anna Lucia Fallacara, Lorenzo Botta, Emmanuele Crespan, André Richters

Bioorg Med Chem Lett· August 2016

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Neuritogenic militarinone-inspired 4-hydroxypyridones target the stress pathway kinase MAP4K4.
Peter Schröder, Tim Förster, Stefan Kleine, Christian Becker, André Richters

Angew Chem Int Ed Engl· October 2015

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Targeting Drug Resistance in EGFR with Covalent Inhibitors: A Structure-Based Design Approach.
Julian Engel, André Richters, Matthäus Getlik, Stefano Tomassi, Marina Keul

J Med Chem· September 2015

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Covalent-Allosteric Kinase Inhibitors.
Jörn Weisner, Rajesh Gontla, Leandi van der Westhuizen, Sebastian Oeck, Julia Ketzer, André Richters

Angew Chem Int Ed Engl· August 2015

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Corrigendum to "Structure-based design and synthesis of covalent-reversible inhibitors to overcome drug resistance in EGFR" [Bioorg. Med. Chem. 23, 2015, 2767-2780].
Debjit Basu, André Richters, Daniel Rauh

Bioorg Med Chem· August 2015

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A Synergistic Interaction between Chk1- and MK2 Inhibitors in KRAS-Mutant Cancer.
Felix Dietlein, Bastian Kalb, Mladen Jokic, Elisa M Noll, Alexander Strong, André Richters

Cell· July 2015

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Structure-based design and synthesis of covalent-reversible inhibitors to overcome drug resistance in EGFR.
Debjit Basu, André Richters, Daniel Rauh

Bioorg Med Chem· June 2015

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Combining X-ray crystallography and molecular modeling toward the optimization of pyrazolo[3,4-d]pyrimidines as potent c-Src inhibitors active in vivo against neuroblastoma.
Cristina Tintori, Anna Lucia Fallacara, Marco Radi, Claudio Zamperini, Elena Dreassi, André Richters

J Med Chem· January 2015

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Identification and further development of potent TBK1 inhibitors.
André Richters, Debjit Basu, Julian Engel, Meryem S Ercanoglu, Hyatt Balke-Want

ACS Chem Biol· January 2015

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Identification of type II and III DDR2 inhibitors.
André Richters, Hoang D Nguyen, Trang Phan, Jeffrey R Simard, Christian Grütter

J Med Chem· May 2014

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Cell-autonomous and non-cell-autonomous mechanisms of transformation by amplified FGFR1 in lung cancer.
Florian Malchers, Felix Dietlein, Jakob Schöttle, Xin Lu, Lucia Nogova, André Richters

Cancer Discov· February 2014

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Metabolically stable dibenzo[b,e]oxepin-11(6H)-ones as highly selective p38 MAP kinase inhibitors: optimizing anti-cytokine activity in human whole blood.
Benjamin Baur, Kirsten Storch, Kathrin E Martz, Marcia I Goettert, André Richters

J Med Chem· November 2013

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Targeting gain of function and resistance mutations in Abl and KIT by hybrid compound design.
André Richters, Julia Ketzer, Matthäus Getlik, Christian Grütter, Ralf Schneider

J Med Chem· July 2013

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De novo design of protein kinase inhibitors by in silico identification of hinge region-binding fragments.
Robert Urich, Grant Wishart, Michael Kiczun, André Richters, Naomi Tidten-Luksch

ACS Chem Biol· May 2013

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