Publications by authors named "Ao-Lin Hsu"

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Distinct systemic impacts of Aβ42 and Tau revealed by whole-organism snRNA-seq.
Ye-Jin Park, Tzu-Chiao Lu, Tyler Jackson, Lindsey D Goodman, Lindsey Ran, Jiaye Chen, Chung-Yi Liang, Erin Harrison, Christina Ko, Xi Chen

Neuron· July 2025

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The impacts of different dietary restriction regimens on aging and longevity: from yeast to humans.
Tsui-Ting Ching, Ao-Lin Hsu

J Biomed Sci· October 2025

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Mitochondrial S-adenosylmethionine deficiency induces mitochondrial unfolded protein response and extends lifespan in Caenorhabditis elegans.
Tse Yu Chen, Feng-Yung Wang, Pin-Jung Lee, Ao-Lin Hsu, Tsui-Ting Ching

Aging Cell· April 2024

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Whole organism snRNA-seq reveals systemic peripheral changes in Alzheimer's Disease fly models.
Ye-Jin Park, Tzu-Chiao Lu, Tyler Jackson, Lindsey D Goodman, Lindsey Ran, Ao-Lin Hsu

bioRxiv· March 2024

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Distinct sets of lysosomal genes define synucleinopathy and tauopathy.
Kyu Won Oh, Dong-Kyu Kim, Ao-Lin Hsu, Seung-Jae Lee

BMB Rep· December 2023

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Activation of eIF4E-binding-protein-1 rescues mTORC1-induced sarcopenia by expanding lysosomal degradation capacity.
Elisa M Crombie, Seonyoung Kim, Stuart Adamson, Han Dong, Tzu-Chiao Lu, Ao-Lin Hsu

J Cachexia Sarcopenia Muscle· February 2023

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SAMS-1 coordinates HLH-30/TFEB and PHA-4/FOXA activities through histone methylation to mediate dietary restriction-induced autophagy and longevity.
Chiao-Yin Lim, Huan-Ting Lin, Caroline Kumsta, Tzu-Chiao Lu, Feng-Yung Wang, Yun-Hsuan Kang, Ao-Lin Hsu

Autophagy· January 2023

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Development of a traditional Chinese medicine-based agent for the treatment of cancer cachexia.
Kun-Chang Wu, Po-Chen Chu, Yu-Jung Cheng, Chia-Ing Li, Jingkui Tian, Ao-Lin Hsu, Chih-Hsueh Lin

J Cachexia Sarcopenia Muscle· August 2022

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Using Convolutional Neural Networks to Measure the Physiological Age of Caenorhabditis elegans.
Jiunn-Liang Lin, Wei-Liang Kuo, Yi-Hao Huang, Tai-Lang Jong, Ao-Lin Hsu, Wen-Hsing Hsu

IEEE/ACM Trans Comput Biol Bioinform· January 2022

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A maze platform for the assessment of behavior and learning.
Eleni Gourgou, Ao-Lin Hsu

STAR Protoc· December 2021

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learning in a structured maze is a multisensory behavior.
Eleni Gourgou, Kavya Adiga, Anne Goettemoeller, Chieh Chen, Ao-Lin Hsu

iScience· April 2021

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S-adenosyl methionine synthetase SAMS-5 mediates dietary restriction-induced longevity in Caenorhabditis elegans.
Chia-Chang Chen, Chiao Yin Lim, Pin-Jung Lee, Ao-Lin Hsu, Tsui-Ting Ching

PLoS One· December 2020

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Short-term enhancement of motor neuron synaptic exocytosis during early aging extends lifespan in .
Tsui-Ting Ching, Yen-Chieh Chen, Guang Li, Jianfeng Liu, X Z Shawn Xu, Ao-Lin Hsu

Exp Biol Med (Maywood)· November 2020

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High-throughput small molecule screening reveals Nrf2-dependent and -independent pathways of cellular stress resistance.
David B Lombard, William J Kohler, Angela H Guo, Christi Gendron, Melissa Han, Ao-Lin Hsu

Sci Adv· October 2020

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HSB-1/HSF-1 pathway modulates histone H4 in mitochondria to control mtDNA transcription and longevity.
Surojit Sural, Chung-Yi Liang, Feng-Yung Wang, Tsui-Ting Ching, Ao-Lin Hsu

Sci Adv· October 2020

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AMPK-mediated formation of stress granules is required for dietary restriction-induced longevity in Caenorhabditis elegans.
Chen-Ting Kuo, Guan-Ting You, Ying-Jie Jian, Ting-Shin Chen, Yu-Chen Siao, Ao-Lin Hsu

Aging Cell· June 2020

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DAF-16 stabilizes the aging transcriptome and is activated in mid-aged Caenorhabditis elegans to cope with internal stress.
Shang-Tong Li, Han-Qing Zhao, Pan Zhang, Chung-Yi Liang, Yan-Ping Zhang, Ao-Lin Hsu

Aging Cell· June 2019

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HSB-1 Inhibition and HSF-1 Overexpression Trigger Overlapping Transcriptional Changes To Promote Longevity in .
Surojit Sural, Tzu-Chiao Lu, Seung Ah Jung, Ao-Lin Hsu

G3 (Bethesda)· May 2019

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Genetic and pharmacological interventions in the aging motor nervous system slow motor aging and extend life span in .
Guang Li, Jianke Gong, Jie Liu, Jinzhi Liu, Huahua Li, Ao-Lin Hsu

Sci Adv· January 2019

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Prefoldin 6 mediates longevity response from heat shock factor 1 to FOXO in .
Heehwa G Son, Keunhee Seo, Mihwa Seo, Sangsoon Park, Seokjin Ham, Ao-Lin Hsu

Genes Dev· December 2018

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Reciprocal Changes in Phosphoenolpyruvate Carboxykinase and Pyruvate Kinase with Age Are a Determinant of Aging in Caenorhabditis elegans.
Yiyuan Yuan, Parvin Hakimi, Clara Kao, Allison Kao, Ruifu Liu, Ao-Lin Hsu

J Biol Chem· January 2016

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Analysis of lifespan-promoting effect of garlic extract by an integrated metabolo-proteomics approach.
Chun-Hao Huang, Fang-Yu Hsu, Yuan-Heng Wu, Linda Zhong, Mu-Yun Tseng, Ao-Lin Hsu

J Nutr Biochem· August 2015

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Environmental Temperature Differentially Modulates C. elegans Longevity through a Thermosensitive TRP Channel.
Bi Zhang, Rui Xiao, Elizabeth A Ronan, Yongqun He, Ao-Lin Hsu

Cell Rep· June 2015

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Co-chaperone p23 regulates C. elegans Lifespan in Response to Temperature.
Makoto Horikawa, Surojit Sural, Ao-Lin Hsu, Adam Antebi

PLoS Genet· April 2015

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Monitoring newly synthesized proteins over the adult life span of Caenorhabditis elegans.
Krishna Vukoti, Xiaokun Yu, Quanhu Sheng, Sudipto Saha, Zhaoyang Feng, Ao-Lin Hsu

J Proteome Res· March 2015

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