Publications by authors named "Brian Chung"

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Determining the value of genomics in healthcare.
Ilias Goranitis, Robin Z Hayeems, Hadley Stevens Smith, James Buchanan, Deirdre Weymann, Brian H Y Chung, Claudia C Y Chung

Nat Med· December 2025

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Mendelian randomisation reveals modifiable pathways and epigenetic markers from childhood maltreatment to neuropsychiatric disorders.
Nicole Ying Ting Ng, John Yen Tang, Jie V Zhao, Christopher Chun Yu Mak, Brian Hon Yin Chung

Br J Psychiatry· November 2025

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Effects of Communicating Genetic Risk of Type 2 Diabetes and Wearable Technologies on Behavioral Outcomes in East Asians: Statistical Analysis Protocol for a Randomized Controlled Trial.
Harrison Hin Sheung Ho, Ziyuan Chen, Job Godino, Michael Multhaup, Derwin King Chung Chan, Brian Hon Yin Chung

JMIR Res Protoc· November 2025

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Humerus Plate-Nail Construct for Salvage of Humeral Nonunion with Failed Free Fibula Flap: Technique and A Report of 2 Cases.
David Riopelle, Brian C Chung, Cassandra Driscoll, Ali Azad, Luke Nicholson

JBJS Case Connect· October 2025

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Integrated genomic and transcriptomic profiling of glioblastoma reveals ecDNA-driven heterogeneity and microenvironmental reprogramming.
Wenshu Tang, Wing Lun Lee, Cario W S Lo, Annie T W Chu, Karrie Mei-Yee Kiang, Brian H Y Chung

Cell Rep· October 2025

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Mutant and Wild-type RAS Crosstalk and Stoichiometric Deficiencies are Determinants of Sensitivity to Targeted Therapies in KRASG12R Pancreatic Ductal Adenocarcinoma.
Mandana Kamgar, G Aaron Hobbs, Raven Davidson, Daniel Dorbin, Juliannie Herrera, Brian Y Chung

Cancer Res· October 2025

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De novo and inherited variants in DDX39B cause a novel neurodevelopmental syndrome.
Kevin T A Booth, Sharayu V Jangam, Martin M C Chui, Kayla Treat, Lorenzo Graziani, Brian H Y Chung

Brain· August 2025

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Total Hip Arthroplasty Among Superobese Patients: Proceed With Caution.
Sagar Telang, Ryan Palmer, Brian C Chung, Jacob R Ball, Kurt Hong

Arthroplast Today· August 2025

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Quaternary ammonium compounds: a standardized nomenclature approach to enhance understanding of an under-studied class of compounds.
Brian N T Chung, Thomas A Bruton, Vicente Samano, Charles N Lowe, Antony J Williams

Integr Environ Assess Manag· August 2025

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Clinical and data-driven optimization of Genomiser for rare disease patients: experience from the Hong Kong Genome Project.
Anson Man Chun Xi, Denis Long Him Yeung, Wei Ma, Dingge Ying, Amy Hin Yan Tong, Brian Hon-Yin Chung

Brief Bioinform· August 2025

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T and B cell responses against Epstein-Barr virus in primary sclerosing cholangitis.
Hesham ElAbd, Mitchell Pesesky, Gabriel Innocenti, Brian K Chung, Aya K H Mahdy

Nat Med· July 2025

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Identification of technically challenging variants: Whole-genome sequencing improves diagnostic yield in patients with high clinical suspicion of rare diseases.
Hau-Yee Ng, Wei Ma, Wai-Kei J Lam, Chak-Sing Lau, Ho-Ming Luk, Brian H Y Chung

HGG Adv· July 2025

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24-Nor-ursodeoxycholic acid improves intestinal inflammation by targeting T17 pathogenicity and transdifferentiation.
Ci Zhu, Nicole Boucheron, Osamah Al-Rubaye, Brian K Chung, Liv Wenche Thorbjørnsen

Gut· June 2025

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Multimodal transcriptomics identifies metallothionein as a novel pathway in primary sclerosing cholangitis.
Brian K Chung, Markus S Jördens, Jonas Øgaard, Henrik Mikael Reims, Benedicte Flateland

Hepatology· June 2025

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A step forward in genetic counselling: defining practice and ethics through the Genetic Counselling Practice Consortium in Hong Kong.
Desiree M S Tse, Brian H Y Chung, , , Annie T W Chu

J Hum Genet· May 2025

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Accelerating genetic diagnostics in retinitis pigmentosa: implementation of a semi-automated bespoke cohort analysis workflow for Hong Kong Genome Project.
Dingge Ying, Jamie Sui Lam Kwok, Annie Tsz Wai Chu, Wei Ma, Helen Ying Fung Tam, Brian Hon Yin Chung

Hum Genet· May 2025

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Artificial intelligence-driven genotype-epigenotype-phenotype approaches to resolve challenges in syndrome diagnostics.
Christopher C Y Mak, Hannah Klinkhammer, Sanaa Choufani, Nikola Reko, Angela K Christman, Brian H Y Chung

EBioMedicine· May 2025

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An outlier approach: advancing diagnosis of neurological diseases through integrating proteomics into multi-omics guided exome reanalysis.
Martin Man-Chun Chui, Anna Ka-Yee Kwong, Hiu Yu Cherie Leung, Chingyiu Pang, Ines F Scheller, Brian Hon-Yin Chung

NPJ Genom Med· May 2025

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A roadmap for genome projects to foster psychosocial and economic evidence to further policy and practice.
Claudia Ching Yan Chung, Annie Tsz Wai Chu, Brian Hon Yin Chung

Commun Med (Lond)· May 2025

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Characterizing the Rotational Profile of the Distal Femur: A Roadmap for Distal Femoral Replacement Surgery.
Matthew S Chen, Kevin C Liu, Matthew C Gallo, Nicholas Kusnezov, Brian C Chung

J Am Acad Orthop Surg· April 2025

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Cellular Crosstalk Promotes Hepatic Progenitor Cell Proliferation and Stellate Cell Activation in 3D Co-culture.
Maya W Haaker, Jung-Chin Chang, Brian K Chung, Tobias S Pieper, Falko Noé

Cell Mol Gastroenterol Hepatol· April 2025

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Experiences of participants with undiagnosed diseases and hereditary cancers during the initial phase of the Hong Kong genome project: a mixed-methods study.
Annie Tw Chu, Samuel Yc Sze, Desiree Ms Tse, Cheryl Wy Lai, Carmen S Ng, Pui-Hong Chung, Brian Hy Chung

Hum Genomics· April 2025

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NDUFB7 mutations cause brain neuronal defects, lactic acidosis, and mitochondrial dysfunction in humans and zebrafish.
Yen-Lin Chen, Brian Hon-Yin Chung, Masakazu Mimaki, Shumpei Uchino, Yin-Hsiu Chien, Ni-Chung Lee

Cell Death Discov· March 2025

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Identifying a Reliable Intra-articular Landmark to Avoid Vascular Injury During Transacetabular Screw Fixation: A 3D Computed Tomography Study.
Hansel E Ihn, Brian C Chung, Luke Lovro, Xiao T Chen, Douglass Tucker

J Am Acad Orthop Surg· February 2025

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The implementation of genome sequencing in rare genetic diseases diagnosis: a pilot study from the Hong Kong genome project.
Wai Kei Jacky Lam, Chak Sing Lau, Ho Ming Luk, Lisa Wing Chi Au, Gary C P Chan, Claudia Ching Yan Chung, Kin Lai Chung, Brian Hon Yin Chung

Lancet Reg Health West Pac· February 2025

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