Publications by authors named "Brian Mahon"

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Design, anticancer activity, and mechanistic evaluation of a novel class of selective human carbonic anhydrase IX inhibitors featuring a trifluorodihydroxypropanone pharmacophore.
Nicolino Pala, Federico Ladu, Wojciech Szlasa, Roberta Cadoni, Carrie Lomelino, Brian P Mahon

Eur J Med Chem· November 2025

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Discovery of Potent and Selective Reversible Ubiquitin-Like Modifier Activating Enzyme 5 Inhibitors Targeting the UFMylation Pathway.
James J Mignone, Elizabeth A Jurica, Deepa Rajasekaran, Jaclyn Robustelli, Courtney McCarthy, Brian P Mahon

J Med Chem· October 2025

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Conformational states of the microtubule nucleator, the γ-tubulin ring complex.
Brianna Romer, Sophie M Travis, Brian P Mahon, Collin T McManus, Philip D Jeffrey

bioRxiv· December 2023

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The conserved centrosomin motif, γTuNA, forms a dimer that directly activates microtubule nucleation by the γ-tubulin ring complex (γTuRC).
Michael J Rale, Brianna Romer, Brian P Mahon, Sophie M Travis, Sabine Petry

Elife· December 2022

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How Microtubules Build the Spindle Branch by Branch.
Sophie M Travis, Brian P Mahon, Sabine Petry

Annu Rev Cell Dev Biol· October 2022

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Biophysical Characterization of Cancer-Related Carbonic Anhydrase IX.
Katarina Koruza, A Briana Murray, Brian P Mahon, Jesse B Hopkins, Wolfgang Knecht

Int J Mol Sci· July 2020

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Methods for Determining and Understanding Serpin Structure and Function: X-Ray Crystallography.
Brian P Mahon, Robert McKenna

Methods Mol Biol· March 2019

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Using neutron crystallography to elucidate the basis of selective inhibition of carbonic anhydrase by saccharin and a derivative.
Katarina Koruza, Brian P Mahon, Matthew P Blakeley, Andreas Ostermann, Tobias E Schrader

J Struct Biol· February 2019

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Detection of a Mammographically Occult Breast Cancer with a Challenging Clinical History.
Quan D Nguyen, James W Randall, Taylor S Harmon, Angelica S Robinson, Claudia Cotes, Brian H Mahon

Cureus· November 2018

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Carbonic anhydrase II microcrystals suitable for XFEL studies.
Carrie L Lomelino, Jin Kyun Kim, Cheol Lee, Seon Woo Lim, Jacob T Andring, Brian P Mahon

Acta Crystallogr F Struct Biol Commun· June 2018

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Crystal Structure of Cleaved Serp-1, a Myxomavirus-Derived Immune Modulating Serpin: Structural Design of Serpin Reactive Center Loop Peptides with Improved Therapeutic Function.
Brian P Mahon, Sriram Ambadapadi, Jordan R Yaron, Carrie L Lomelino, Melissa A Pinard

Biochemistry· February 2018

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Carbonic Anhydrases: Role in pH Control and Cancer.
Mam Y Mboge, Brian P Mahon, Robert McKenna, Susan C Frost

Metabolites· February 2018

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Active-site solvent replenishment observed during human carbonic anhydrase II catalysis.
Jin Kyun Kim, Carrie L Lomelino, Balendu Sankara Avvaru, Brian P Mahon, Robert McKenna

IUCrJ· January 2018

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Exploring Heteroaryl-pyrazole Carboxylic Acids as Human Carbonic Anhydrase XII Inhibitors.
Roberta Cadoni, Nicolino Pala, Carrie Lomelino, Brian P Mahon, Robert McKenna

ACS Med Chem Lett· September 2017

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Structure activity study of carbonic anhydrase IX: Selective inhibition with ureido-substituted benzenesulfonamides.
Mam Y Mboge, Brian P Mahon, Nicole Lamas, Lillien Socorro, Fabrizio Carta

Eur J Med Chem· May 2017

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Structure-Activity Relationships of Benzenesulfonamide-Based Inhibitors towards Carbonic Anhydrase Isoform Specificity.
Avni Bhatt, Brian P Mahon, Vinicius Wilian D Cruzeiro, Benedetta Cornelio, Marie Laronze-Cochard

Chembiochem· January 2017

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Effects of Hinge-region Natural Polymorphisms on Human Immunodeficiency Virus-Type 1 Protease Structure, Dynamics, and Drug Pressure Evolution.
Zhanglong Liu, Xi Huang, Lingna Hu, Linh Pham, Katye M Poole, Brian P Mahon

J Biol Chem· October 2016

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The Structure of Carbonic Anhydrase IX Is Adapted for Low-pH Catalysis.
Brian P Mahon, Avni Bhatt, Lilien Socorro, Jenna M Driscoll, Cynthia Okoh

Biochemistry· August 2016

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Targeting aggressive cancers with an artificial sweetener: could saccharin be a lead compound in anticancer therapy?
Brian P Mahon, Cynthia O Okoh, Robert McKenna

Future Oncol· April 2016

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Kinetic and X-ray crystallographic investigations on carbonic anhydrase isoforms I, II, IX and XII of a thioureido analog of SLC-0111.
Carrie L Lomelino, Brian P Mahon, Robert McKenna, Fabrizio Carta, Claudiu T Supuran

Bioorg Med Chem· March 2016

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Sulfonamide inhibition studies of the α-carbonic anhydrase from the gammaproteobacterium Thiomicrospira crunogena XCL-2, TcruCA.
Daniela Vullo, Avni Bhatt, Brian P Mahon, Robert McKenna, Claudiu T Supuran

Bioorg Med Chem Lett· January 2016

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Observed surface lysine acetylation of human carbonic anhydrase II expressed in Escherichia coli.
Brian P Mahon, Carrie L Lomelino, Antonieta L Salguero, Jenna M Driscoll, Melissa A Pinard

Protein Sci· November 2015

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A sucrose-binding site provides a lead towards an isoform-specific inhibitor of the cancer-associated enzyme carbonic anhydrase IX.
Melissa A Pinard, Mayank Aggarwal, Brian P Mahon, Chingkuang Tu, Robert McKenna

Acta Crystallogr F Struct Biol Commun· October 2015

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Structural and biophysical characterization of the α-carbonic anhydrase from the gammaproteobacterium Thiomicrospira crunogena XCL-2: insights into engineering thermostable enzymes for CO2 sequestration.
Natalia A Díaz-Torres, Brian P Mahon, Christopher D Boone, Melissa A Pinard, Chingkuang Tu

Acta Crystallogr D Biol Crystallogr· August 2015

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