Publications by authors named "C Pannecouque"

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Structure- and Privileged Fragment-Based Iterative Optimization: Discovery of 2,4-Disubstituted-6-aminopyrimidines as Novel HIV-1 NNRTIs with Potent Activity against Drug-Resistant Strains and Favorable Safety Profiles.
Xiangkai Ji, Xiangyi Jiang, Heng Gao, Zhen Gao, Erik De Clercq, Christophe Pannecouque

J Med Chem· November 2025

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Correction to "Exploring the HIV-1 Reverse Transcriptase p51/p66 Interface: Structure-Based Design and Optimization of Novel 2,4,6-Trisubstituted Pyrimidines as Potent NNRTIs with Improved Resistance Profiles".
Xiangkai Ji, Xiangyi Jiang, Zhen Gao, Heng Gao, Xing Huang, Christophe Pannecouque

J Med Chem· November 2025

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Exploring the HIV-1 Reverse Transcriptase p51/p66 Interface: Structure-Based Design and Optimization of Novel 2,4,6-Trisubstituted Pyrimidines as Potent NNRTIs with Improved Resistance Profiles.
Xiangkai Ji, Xiangyi Jiang, Zhen Gao, Heng Gao, Xing Huang, Christophe Pannecouque

J Med Chem· October 2025

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Design, synthesis, and biological evaluation of dual-site HIV-1 inhibitors simultaneously targeting the NNRTI binding pocket and an adjacent site with favorable resistance profiles.
Xiangkai Ji, Xiangyi Jiang, Xing Huang, Heng Gao, Zhen Gao, Christophe Pannecouque

Bioorg Chem· September 2025

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Bioisosterism-driven design of orally active, safe, and broad-spectrum biphenyl-DAPY derivatives as highly potent HIV-1 non-nucleoside reverse transcriptase inhibitors.
Xiao-Mei Chen, Qing-Qing Hao, Christophe Pannecouque, Erik De Clercq, Shuai Wang

Acta Pharm Sin B· August 2025

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