Publications by authors named "Chelsea Hepler"

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Time-restricted feeding mitigates obesity through adipocyte thermogenesis.
Chelsea Hepler, Benjamin J Weidemann, Nathan J Waldeck, Biliana Marcheva, Jonathan Cedernaes, Anneke K Thorne, Yumiko Kobayashi, Rino Nozawa, Marsha V Newman, Peng Gao

Science· October 2022

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Sensory-neuron-derived CGRPα controls white adipocyte differentiation and tissue plasticity.
Kyle D Dumont, Saba Seradj, Yu Wang, Shanshan Liu, Igor Cervenka, Chelsea Hepler

Cell Rep· November 2025

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NADH dehydrogenase reverses dietary and clock metabolic syndrome.
Chelsea Hepler, Nathan J Waldeck, Benjamin J Weidemann, Biliana Marcheva, You-Jia Chen

bioRxiv· October 2025

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Integrating multi-omics in bile for biomarker discovery in cholangiocarcinoma.
Jonathan Y Xia, Srinadh Komanduri, Rajesh N Keswani, Terrance R Rodrigues, Jasmine Sinha, Chelsea Hepler

Hepatol Commun· September 2025

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Misaligned feeding uncouples daily rhythms within brown adipose tissue and between peripheral clocks.
Victoria A Acosta-Rodríguez, Filipa Rijo-Ferreira, Laura van Rosmalen, Mariko Izumo, Noheon Park, Chelsea Hepler

Cell Rep· August 2024

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Engineered calprotectin-sensing probiotics for IBD surveillance in humans.
Jonathan Y Xia, Chelsea Hepler, Peter Tran, Nathan J Waldeck, Joseph Bass

Proc Natl Acad Sci U S A· August 2023

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Circadian mechanisms in adipose tissue bioenergetics and plasticity.
Chelsea Hepler, Joseph Bass

Genes Dev· June 2023

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Adipocyte mesenchymal transition contributes to mammary tumor progression.
Qingzhang Zhu, Yi Zhu, Chelsea Hepler, Qianbin Zhang, Jiyoung Park

Cell Rep· September 2022

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NADH inhibition of SIRT1 links energy state to transcription during time-restricted feeding.
Daniel C Levine, Hsin-Yu Kuo, Hee-Kyung Hong, Jonathan Cedernaes, Chelsea Hepler

Nat Metab· December 2021

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Supplements to treat prediabetes.
Chelsea Hepler, Joseph Bass

Science· June 2021

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Hepatocyte membrane potential regulates serum insulin and insulin sensitivity by altering hepatic GABA release.
Caroline E Geisler, Susma Ghimire, Chelsea Hepler, Kendra E Miller, Stephanie M Bruggink

Cell Rep· June 2021

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Roadmap on biology in time varying environments.
Arvind Murugan, Kabir Husain, Michael J Rust, Chelsea Hepler, Joseph Bass

Phys Biol· May 2021

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Mitochondrial metabolism is a key regulator of the fibro-inflammatory and adipogenic stromal subpopulations in white adipose tissue.
Nolwenn Joffin, Vivian A Paschoal, Christy M Gliniak, Clair Crewe, Abdallah Elnwasany, Chelsea Hepler

Cell Stem Cell· April 2021

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Pathologic HIF1α signaling drives adipose progenitor dysfunction in obesity.
Mengle Shao, Chelsea Hepler, Qianbin Zhang, Bo Shan, Lavanya Vishvanath

Cell Stem Cell· April 2021

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Perivascular mesenchymal cells control adipose-tissue macrophage accrual in obesity.
Bo Shan, Mengle Shao, Qianbin Zhang, Chelsea Hepler, Vivian A Paschoal

Nat Metab· November 2020

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Dermal adipose tissue has high plasticity and undergoes reversible dedifferentiation in mice.
Zhuzhen Zhang, Mengle Shao, Chelsea Hepler, Zhenzhen Zi, Shangang Zhao

J Clin Invest· December 2019

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Identification of functionally distinct fibro-inflammatory and adipogenic stromal subpopulations in visceral adipose tissue of adult mice.
Chelsea Hepler, Bo Shan, Qianbin Zhang, Gervaise H Henry, Mengle Shao

Elife· September 2018

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Acute loss of adipose tissue-derived adiponectin triggers immediate metabolic deterioration in mice.
Jonathan Y Xia, Kai Sun, Chelsea Hepler, Alexandra L Ghaben, Rana K Gupta

Diabetologia· April 2018

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De novo adipocyte differentiation from Pdgfrβ preadipocytes protects against pathologic visceral adipose expansion in obesity.
Mengle Shao, Lavanya Vishvanath, Napoleon C Busbuso, Chelsea Hepler, Bo Shan

Nat Commun· March 2018

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Directing visceral white adipocyte precursors to a thermogenic adipocyte fate improves insulin sensitivity in obese mice.
Chelsea Hepler, Mengle Shao, Jonathan Y Xia, Alexandra L Ghaben, Mackenzie J Pearson

Elife· July 2017

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The expanding problem of adipose depot remodeling and postnatal adipocyte progenitor recruitment.
Chelsea Hepler, Rana K Gupta

Mol Cell Endocrinol· April 2017

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Fetal development of subcutaneous white adipose tissue is dependent on Zfp423.
Mengle Shao, Chelsea Hepler, Lavanya Vishvanath, Karen A MacPherson, Napoleon C Busbuso

Mol Metab· January 2017

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Sorting out adipocyte precursors and their role in physiology and disease.
Chelsea Hepler, Lavanya Vishvanath, Rana K Gupta

Genes Dev· January 2017

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β1-Adrenergic receptor deficiency in ghrelin-expressing cells causes hypoglycemia in susceptible individuals.
Bharath K Mani, Sherri Osborne-Lawrence, Prasanna Vijayaraghavan, Chelsea Hepler, Jeffrey M Zigman

J Clin Invest· September 2016

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Zfp423 Maintains White Adipocyte Identity through Suppression of the Beige Cell Thermogenic Gene Program.
Mengle Shao, Jeff Ishibashi, Christine M Kusminski, Qiong A Wang, Chelsea Hepler

Cell Metab· June 2016

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