Publications by authors named "Cheng-Tian Lin"

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RNA inosine sensor-guided TadA mutational scanning for toxicity minimization of adenine base editors.
Cheng Zhang, Ziliang Chen, Jixin Cao, Zui Zhang, Wei-Ke Li, Tian-Lin Cheng

Mol Ther· October 2025

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UGI relocation inside Cas9 reduces Cas9 dependent off target effects in cytosine base editors.
Zehao Shi, Tian-Lin Cheng

Sci Rep· October 2025

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Selective loss of Scn2a in ventral tegmental area dopaminergic neurons leads to dopamine system hypofunction and autistic-like behaviors.
Liang Li, Qi Huang, Jiahao Hu, Mengmeng Jin, Yizhou Zhuo, Tian-Lin Cheng, Yilin Tai

Neuron· September 2025

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Author Correction: Endocannabinoids disinhibit the ventral tegmental nucleus of Gudden to dorsal premammillary nucleus pathway to enhance escape behavior following learned threat experience.
Ruikai Chai, Nawen Wang, Jinlu Nie, Zongyi Xu, Shuqian Zhang, Tian-Lin Cheng, Huilin Hong

Nat Commun· September 2025

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MS4A6A/Ms4a6d deficiency disrupts neuroprotective microglia functions and promotes inflammation in Alzheimer's disease model.
Hai-Shan Jiao, Yi-Jun Ge, Liang-Yu Huang, Ying Liu, Bang-Sheng Wu, Tian-Lin Cheng

Mol Neurodegener· August 2025

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Endocannabinoids disinhibit the ventral tegmental nucleus of Gudden to dorsal premammillary nucleus pathway to enhance escape behavior following learned threat experience.
Ruikai Chai, Nawen Wang, Jinlu Nie, Zongyi Xu, Shuqian Zhang, Tian-Lin Cheng, Huilin Hong

Nat Commun· May 2025

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Integrating rare pathogenic variant prioritization with gene-based association analysis to identify novel genes and relevant multimodal traits for Alzheimer's disease.
Jixin Cao, Cheng Zhang, Chun-Yi Zac Lo, Qihao Guo, Jing Ding, Tian-Lin Cheng

Alzheimers Dement· February 2025

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Neuromuscular organoids model spinal neuromuscular pathologies in C9orf72 amyotrophic lateral sclerosis.
Chong Gao, Qinghua Shi, Xue Pan, Jiajia Chen, Yuhong Zhang, Tian-Lin Cheng

Cell Rep· March 2024

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Whole-brain in vivo base editing reverses behavioral changes in Mef2c-mutant mice.
Wei-Ke Li, Shu-Qian Zhang, Wan-Ling Peng, Yu-Han Shi, Bo Yuan, Yi-Lin Tai, Tian-Lin Cheng

Nat Neurosci· January 2024

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Engineering of cytosine base editors with DNA damage minimization and editing scope diversification.
Bo Yuan, Shuqian Zhang, Liting Song, Jinlong Chen, Jixin Cao, Tian-Lin Cheng

Nucleic Acids Res· November 2023

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Corrigendum to "Induction of core symptoms of autism spectrum disorders by in vivo CRISPR/Cas9-based gene editing in the brain of adolescent rhesus monkeys" [Sci. Bull. 66(9) (2021) 937-946].
Shi-Hao Wu, Xiao Li, Dong-Dong Qin, Lin-Heng Zhang, Tian-Lin Cheng, Yi-Lin Gu

Sci Bull (Beijing)· March 2023

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TadA orthologs enable both cytosine and adenine editing of base editors.
Shuqian Zhang, Bo Yuan, Jixin Cao, Liting Song, Jinlong Chen, Tian-Lin Cheng

Nat Commun· January 2023

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TadA reprogramming to generate potent miniature base editors with high precision.
Shuqian Zhang, Liting Song, Bo Yuan, Cheng Zhang, Jixin Cao, Yilin Tai, Tian-Lin Cheng

Nat Commun· January 2023

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Induction of core symptoms of autism spectrum disorder by in vivo CRISPR/Cas9-based gene editing in the brain of adolescent rhesus monkeys.
Shi-Hao Wu, Xiao Li, Dong-Dong Qin, Lin-Heng Zhang, Tian-Lin Cheng, Yi-Lin Gu

Sci Bull (Beijing)· May 2021

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Docking sites inside Cas9 for adenine base editing diversification and RNA off-target elimination.
Shuo Li, Bo Yuan, Jixin Cao, Jingqi Chen, Jinlong Chen, Xiaolin Wang, Tian-Lin Cheng

Nat Commun· November 2020

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Visualization and correction of social abnormalities-associated neural ensembles in adult MECP2 duplication mice.
Le Sun, Ruiguo Chen, Long Li, Bo Yuan, Kun Song, Tian-Lin Cheng, Kunzhang Lin

Sci Bull (Beijing)· July 2020

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Reversal of Social Recognition Deficit in Adult Mice with MECP2 Duplication via Normalization of MeCP2 in the Medial Prefrontal Cortex.
Bin Yu, Bo Yuan, Jian-Kun Dai, Tian-Lin Cheng, Sheng-Nan Xia, Ling-Jie He

Neurosci Bull· June 2020

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Efficient and risk-reduced genome editing using double nicks enhanced by bacterial recombination factors in multiple species.
Xiaozhen He, Wenfeng Chen, Zhen Liu, Guirong Yu, Youbang Chen, Ling Sun, Tian-Lin Cheng

Nucleic Acids Res· June 2020

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Expanding C-T base editing toolkit with diversified cytidine deaminases.
Tian-Lin Cheng, Shuo Li, Bo Yuan, Xiaolin Wang, Wenhao Zhou

Nat Commun· August 2019

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Long non-coding RNA tagging and expression manipulation via CRISPR/Cas9-mediated targeted insertion.
Tian-Lin Cheng, Zilong Qiu

Protein Cell· September 2018

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Identification of autism-related mutations by whole-exome sequencing and functional validation.
Zhu Wen, Tian-Lin Cheng, Gai-Zhi Li, Shi-Bang Sun, Shun-Ying Yu

Mol Autism· May 2018

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Identification of the Genetic Cause for Childhood Disintegrative Disorder by Whole-Exome Sequencing.
Zhu Wen, Tian-Lin Cheng, Da-Zhi Yin, Shi-Bang Sun, Zheng Wang

Neurosci Bull· April 2017

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Regulation of mRNA splicing by MeCP2 via epigenetic modifications in the brain.
Tian-Lin Cheng, Jingqi Chen, Huida Wan, Bin Tang, Weidong Tian

Sci Rep· February 2017

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Autism-related protein MeCP2 regulates FGF13 expression and emotional behaviors.
Bo Yuan, Tian-Lin Cheng, Kan Yang, Xu Zhang, Zilong Qiu

J Genet Genomics· January 2017

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Reciprocal regulation of autism-related genes MeCP2 and PTEN via microRNAs.
Jing-Wen Lyu, Bo Yuan, Tian-Lin Cheng, Zi-Long Qiu, Wen-Hao Zhou

Sci Rep· February 2016

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