Publications by authors named "Christian Badr"

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Dual-action nanotherapy: Temozolomide-loaded, anti-PD-L1 scFv-functionalized lipid nanocarriers for targeted glioblastoma therapy.
Eren Aytekin, Semer Maksoud, Bakhos A Tannous, Sibel Bozdağ Pehlivan, Christian E Badr

Eur J Pharm Sci· October 2025

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Current and Emerging Fluorescence-Guided Techniques in Glioma to Enhance Resection.
Trang T T Nguyen, Hayk Mnatsakanyan, Eunhee Yi, Christian E Badr

Cancers (Basel)· August 2025

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SCD1 and SCD5 Modulate PARP-Dependent DNA Repair via Fatty Acid Desaturation in Glioblastoma.
Hayk Mnatsakanyan, Alessandro Sammarco, Rami Awwad, Abigail Hewett, Elie Roumieh, Christian E Badr

bioRxiv· July 2025

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Targeting SCD triggers lipotoxicity of cancer cells and enhances anti-tumor immunity in breast cancer brain metastasis mouse models.
Alessandro Sammarco, Giorgia Guerra, Katharina M Eyme, Kelly Kennewick, Yu Qiao, Christian E Badr

Commun Biol· April 2025

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Expression-based selection identifies a microglia-tropic AAV capsid for direct and CSF routes of administration in mice.
Miguel C Santoscoy, Paula Espinoza, Killian S Hanlon, Luna Yang, Lisa Nieland, Christian E Badr

bioRxiv· September 2024

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Diastereomers of Coibamide A Show Altered Sec61 Client Selectivity and Ligand-Dependent Activity against Patient-Derived Glioma Stem-like Cells.
Daphne R Mattos, Willian das Neves, Takashi Kitamura, Richa Pradhan, Xuemei Wan, Christian E Badr

ACS Pharmacol Transl Sci· June 2024

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Revolutionizing Brain Tumor Care: Emerging Technologies and Strategies.
Trang T T Nguyen, Lloyd A Greene, Hayk Mnatsakanyan, Christian E Badr

Biomedicines· June 2024

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Targeting SCD triggers lipotoxicity of cancer cells and enhances anti-tumor immunity in breast cancer brain metastasis mouse models.
Alessandro Sammarco, Giorgia Guerra, Katharina M Eyme, Kelly Kennewick, Yu Qiao, Christian E Badr

bioRxiv· May 2024

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Targeting de novo lipid synthesis induces lipotoxicity and impairs DNA damage repair in glioblastoma mouse models.
Katharina M Eyme, Alessandro Sammarco, Roshani Jha, Hayk Mnatsakanyan, Caline Pechdimaljian, Christian E Badr

Sci Transl Med· January 2023

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Orthotopic brain tumor models derived from glioblastoma stem-like cells.
Katharina M Eyme, Alessandro Sammarco, Christian E Badr

Methods Cell Biol· July 2022

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Multiplexed bioluminescence-mediated tracking of DNA double-strand break repairs in vitro and in vivo.
Jasper Che-Yung Chien, Christian E Badr, Charles Pin-Kuang Lai

Nat Protoc· August 2021

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Intranasal delivery of experimental compounds in orthotopic brain tumor mouse models.
Katharina M Eyme, Litia Carvalho, Christian E Badr

STAR Protoc· March 2021

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Targeting of HER/ErbB family proteins using broad spectrum Sec61 inhibitors coibamide A and apratoxin A.
Soheila Kazemi, Shinsaku Kawaguchi, Christian E Badr, Daphne R Mattos, Ana Ruiz-Saenz

Biochem Pharmacol· January 2021

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Metabolic heterogeneity and adaptability in brain tumors.
Christian E Badr, Daniel J Silver, Florian A Siebzehnrubl, Loic P Deleyrolle

Cell Mol Life Sci· December 2020

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A multiplexed bioluminescent reporter for sensitive and non-invasive tracking of DNA double strand break repair dynamics in vitro and in vivo.
Jasper Che-Yung Chien, Elie Tabet, Kelsey Pinkham, Cintia Carla da Hora, Jason Cheng-Yu Chang, Christian E Badr

Nucleic Acids Res· September 2020

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Obtusaquinone: A Cysteine-Modifying Compound That Targets Keap1 for Degradation.
Christian E Badr, Cintia Carla da Hora, Aleksandar B Kirov, Elie Tabet, Romain Amante

ACS Chem Biol· June 2020

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An allosteric inhibitor of SHP2 effectively targets PDGFRα-driven glioblastoma.
Bakhos A Tannous, Christian E Badr

Neuro Oncol· November 2019

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Erratum: Author Correction: Sustained NF-κB-STAT3 signaling promotes resistance to Smac mimetics in Glioma stem-like cells but creates a vulnerability to EZH2 inhibition.
Cintia Carla da Hora, Kelsey Pinkham, Litia Carvalho, Max Zinter, Elie Tabet, Christian E Badr

Cell Death Discov· June 2019

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Stearoyl CoA Desaturase Is Essential for Regulation of Endoplasmic Reticulum Homeostasis and Tumor Growth in Glioblastoma Cancer Stem Cells.
Kelsey Pinkham, David Jaehyun Park, Arsalan Hashemiaghdam, Aleksandar B Kirov, Isam Adam, Christian E Badr

Stem Cell Reports· April 2019

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Sustained NF-κB-STAT3 signaling promotes resistance to Smac mimetics in Glioma stem-like cells but creates a vulnerability to EZH2 inhibition.
Cintia Carla da Hora, Kelsey Pinkham, Litia Carvalho, Max Zinter, Elie Tabet, Christian E Badr

Cell Death Discov· March 2019

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A TNF-NF-κB-STAT3 loop triggers resistance of glioma-stem-like cells to Smac mimetics while sensitizing to EZH2 inhibitors.
Bakhos A Tannous, Christian E Badr

Cell Death Dis· March 2019

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Virus vector-mediated genetic modification of brain tumor stromal cells after intravenous delivery.
Adrienn Volak, Stanley G LeRoy, Jeya Shree Natasan, David J Park, Pike See Cheah, Christian E Badr

J Neurooncol· September 2018

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Dissecting inherent intratumor heterogeneity in patient-derived glioblastoma culture models.
Jian Teng, Cintia C da Hora, Rami S Kantar, Ichiro Nakano, Hiroaki Wakimoto, Christian E Badr

Neuro Oncol· June 2017

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Systemically administered AAV9-sTRAIL combats invasive glioblastoma in a patient-derived orthotopic xenograft model.
Matheus Hw Crommentuijn, Rami Kantar, David P Noske, W Peter Vandertop, Christian E Badr

Mol Ther Oncolytics· July 2016

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