Publications by authors named "Christophe Verlinde"

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Repurposing Infectious Disease Hits as Anti- Leads.
Matthew A Hulverson, Ryan Choi, Molly C McCloskey, Grant R Whitman, Kayode K Ojo, Christophe L M J Verlinde

ACS Infect Dis· May 2021

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Spontaneous Selection of Drug Resistance in a Calf Model of Infection.
Muhammad M Hasan, Erin E Stebbins, Robert K M Choy, J Robert Gillespie, Eugenio L de Hostos, Christophe L M J Verlinde

Antimicrob Agents Chemother· May 2021

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Structure-guided discovery of selective methionyl-tRNA synthetase inhibitors with potent activity against .
Zhongsheng Zhang, Ximena Barros-Álvarez, J Robert Gillespie, Ranae M Ranade, Wenlin Huang, Christophe L M J Verlinde

RSC Med Chem· August 2020

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Optimization of Methionyl tRNA-Synthetase Inhibitors for Treatment of Infection.
Frederick S Buckner, Ranae M Ranade, J Robert Gillespie, Sayaka Shibata, Matthew A Hulverson, Christophe L M J Verlinde

Antimicrob Agents Chemother· April 2019

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The crystal structure of the drug target Mycobacterium tuberculosis methionyl-tRNA synthetase in complex with a catalytic intermediate.
Ximena Barros-Álvarez, Stewart Turley, Ranae M Ranade, J Robert Gillespie, Nicole A Duster, Christophe L M J Verlinde

Acta Crystallogr F Struct Biol Commun· April 2018

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The calcium-dependent protein kinase 1 from Toxoplasma gondii as target for structure-based drug design.
Emily M Cardew, Christophe L M J Verlinde, Ehmke Pohl

Parasitology· February 2018

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Development of Methionyl-tRNA Synthetase Inhibitors as Antibiotics for Gram-Positive Bacterial Infections.
Omeed Faghih, Zhongsheng Zhang, Ranae M Ranade, J Robert Gillespie, Sharon A Creason, Christophe L M J Verlinde

Antimicrob Agents Chemother· November 2017

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Leishmania donovani tyrosyl-tRNA synthetase structure in complex with a tyrosyl adenylate analog and comparisons with human and protozoan counterparts.
Ximena Barros-Álvarez, Keshia M Kerchner, Cho Yeow Koh, Stewart Turley, Els Pardon, Christophe L M J Verlinde

Biochimie· July 2017

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Optimization of a binding fragment targeting the "enlarged methionine pocket" leads to potent Trypanosoma brucei methionyl-tRNA synthetase inhibitors.
Wenlin Huang, Zhongsheng Zhang, Ranae M Ranade, J Robert Gillespie, Ximena Barros-Álvarez, Christophe L M J Verlinde

Bioorg Med Chem Lett· June 2017

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Structure-guided design of novel Trypanosoma brucei Methionyl-tRNA synthetase inhibitors.
Wenlin Huang, Zhongsheng Zhang, Ximena Barros-Álvarez, Cho Yeow Koh, Ranae M Ranade, Christophe L M J Verlinde

Eur J Med Chem· November 2016

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5-Fluoroimidazo[4,5-b]pyridine Is a Privileged Fragment That Conveys Bioavailability to Potent Trypanosomal Methionyl-tRNA Synthetase Inhibitors.
Zhongsheng Zhang, Cho Yeow Koh, Ranae M Ranade, Sayaka Shibata, J Robert Gillespie, Christophe L M J Verlinde

ACS Infect Dis· June 2016

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Inhibitors of methionyl-tRNA synthetase have potent activity against Giardia intestinalis trophozoites.
Ranae M Ranade, Zhongsheng Zhang, J Robert Gillespie, Sayaka Shibata, Christophe L M J Verlinde

Antimicrob Agents Chemother· November 2015

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A binding hotspot in Trypanosoma cruzi histidyl-tRNA synthetase revealed by fragment-based crystallographic cocktail screens.
Cho Yeow Koh, Latha Kallur Siddaramaiah, Ranae M Ranade, Jasmine Nguyen, Tengyue Jian, Christophe L M J Verlinde

Acta Crystallogr D Biol Crystallogr· August 2015

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Identification of potent inhibitors of the Trypanosoma brucei methionyl-tRNA synthetase via high-throughput orthogonal screening.
Laura Pedró-Rosa, Frederick S Buckner, Ranae M Ranade, Christina Eberhart, Franck Madoux, Christophe L M Verlinde

J Biomol Screen· January 2015

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Structures of Trypanosoma brucei methionyl-tRNA synthetase with urea-based inhibitors provide guidance for drug design against sleeping sickness.
Cho Yeow Koh, Jessica E Kim, Allan B Wetzel, Will J de van der Schueren, Sayaka Shibata, Christophe L M J Verlinde

PLoS Negl Trop Dis· April 2014

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Development of potent and selective Plasmodium falciparum calcium-dependent protein kinase 4 (PfCDPK4) inhibitors that block the transmission of malaria to mosquitoes.
Rama Subba Rao Vidadala, Kayode K Ojo, Steven M Johnson, Zhongsheng Zhang, Stephen E Leonard, Christophe L M J Verlinde

Eur J Med Chem· March 2014

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A specific inhibitor of PfCDPK4 blocks malaria transmission: chemical-genetic validation.
Kayode K Ojo, Richard T Eastman, Ramasubbarao Vidadala, Zhongsheng Zhang, Kasey L Rivas, Christophe L M J Verlinde

J Infect Dis· January 2014

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Potent and selective inhibitors of CDPK1 from and based on a 5-aminopyrazole-4-carboxamide scaffold.
Zhongsheng Zhang, Kayode K Ojo, Ramasubbarao Vidadala, Wenlin Huang, Jennifer A Geiger, Christophe L M J Verlinde

ACS Med Chem Lett· January 2014

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Dialkylimidazole inhibitors of Trypanosoma cruzi sterol 14α-demethylase as anti-Chagas disease agents.
Praveen Kumar Suryadevara, Kishore Kumar Racherla, Srinivas Olepu, Neil R Norcross, Hari Babu Tatipaka, Christophe L M J Verlinde

Bioorg Med Chem Lett· December 2013

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The structure of the D3 domain of Plasmodium falciparum myosin tail interacting protein MTIP in complex with a nanobody.
Susmita Khamrui, Stewart Turley, Els Pardon, Jan Steyaert, Erkang Fan, Christophe L M J Verlinde

Mol Biochem Parasitol· August 2013

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Induced resistance to methionyl-tRNA synthetase inhibitors in Trypanosoma brucei is due to overexpression of the target.
Ranae M Ranade, J Robert Gillespie, Sayaka Shibata, Christophe L M J Verlinde, Erkang Fan

Antimicrob Agents Chemother· July 2013

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Crystal structures of Plasmodium falciparum cytosolic tryptophanyl-tRNA synthetase and its potential as a target for structure-guided drug design.
Cho Yeow Koh, Jessica E Kim, Alberto J Napoli, Christophe L M J Verlinde, Erkang Fan

Mol Biochem Parasitol· May 2013

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Distinct states of methionyl-tRNA synthetase indicate inhibitor binding by conformational selection.
Cho Yeow Koh, Jessica E Kim, Sayaka Shibata, Ranae M Ranade, Mingyan Yu, Christophe L M J Verlinde

Structure· October 2012

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Structure of the prolyl-tRNA synthetase from the eukaryotic pathogen Giardia lamblia.
Eric T Larson, Jessica E Kim, Alberto J Napuli, Christophe L M J Verlinde, Erkang Fan

Acta Crystallogr D Biol Crystallogr· September 2012

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Benzoylbenzimidazole-based selective inhibitors targeting Cryptosporidium parvum and Toxoplasma gondii calcium-dependent protein kinase-1.
Zhongsheng Zhang, Kayode K Ojo, Steven M Johnson, Eric T Larson, Penqing He, Christophe L M J Verlinde

Bioorg Med Chem Lett· August 2012

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