Publications by authors named "Colin Levy"

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Structural basis of terephthalate recognition by solute binding protein TphC.
Trishnamoni Gautom, Dharmendra Dheeman, Colin Levy, Thomas Butterfield, Guadalupe Alvarez Gonzalez, Philip Le Roy, Lewis Caiger, Karl Fisher, Linus Johannissen, Neil Dixon

October 2021

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Enzymatic synthesis of key RNA therapeutic building blocks using simple phosphate donors.
Qinglong Meng, Caecilie Benckendorff, Charlotte Morrill, Ying Zhuo, Annette Egerström, Colin W Levy

Nat Commun· December 2025

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Biocatalytic Activation of Sulfur Heteroaromatics Facilitates Dearomatizing Cross-Couplings to Set Stereogenic Centers or Axes.
Órla Conboy, Emily Q Rushworth, Christopher J Taylor, Colin W Levy, Mary Ortmayer

J Am Chem Soc· November 2025

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Efficient and selective energy transfer photoenzymes powered by visible light.
Rebecca Crawshaw, Ross Smithson, Johannes Hofer, Florence J Hardy, George W Roberts, Colin W Levy

Nat Chem· July 2025

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Fragment-Based Development of Small Molecule Inhibitors Targeting Cholesterol Metabolism.
Madeline E Kavanagh, Kirsty J McLean, Sophie H Gilbert, Cecilia N Amadi, Matthew Snee, Colin W Levy

J Med Chem· July 2025

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The structural organisation of pentraxin-3 and its interactions with heavy chains of inter-α-inhibitor regulate crosslinking of the hyaluronan matrix.
Anokhi Shah, Xiaoli Zhang, Matthew Snee, Michael P Lockhart-Cairns, Colin W Levy

Matrix Biol· April 2025

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Fragment-based development of small molecule inhibitors targeting cholesterol metabolism.
Madeline E Kavanagh, Kirsty J McLean, Sophie H Gilbert, Cecilia Amadi, Matthew Snee, Colin W Levy

bioRxiv· December 2024

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Cryptic enzymatic assembly of peptides armed with β-lactone warheads.
Guangcai Xu, Daniele Torri, Sebastian Cuesta-Hoyos, Deepanjan Panda, Luke R L Yates, Colin Levy

Nat Chem Biol· October 2024

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Probing Ferryl Reactivity in a Nonheme Iron Oxygenase Using an Expanded Genetic Code.
Florence J Hardy, Matthew G Quesne, Emilie F Gérard, Jingming Zhao, Mary Ortmayer, Colin W Levy

ACS Catal· August 2024

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Photocobilins integrate B and bilin photochemistry for enzyme control.
Shaowei Zhang, Laura N Jeffreys, Harshwardhan Poddar, Yuqi Yu, Chuanyang Liu, Colin W Levy

Nat Commun· March 2024

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Biocatalysis in Drug Design: Engineered Reductive Aminases (RedAms) Are Used to Access Chiral Building Blocks with Multiple Stereocenters.
Arnau Rué Casamajo, Yuqi Yu, Christian Schnepel, Charlotte Morrill, Rhys Barker, Colin W Levy

J Am Chem Soc· October 2023

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Redox driven B-ligand switch drives CarH photoresponse.
Harshwardhan Poddar, Ronald Rios-Santacruz, Derren J Heyes, Muralidharan Shanmugam, Adam Brookfield, Colin W Levy

Nat Commun· August 2023

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Design of Heme Enzymes with a Tunable Substrate Binding Pocket Adjacent to an Open Metal Coordination Site.
Indrek Kalvet, Mary Ortmayer, Jingming Zhao, Rebecca Crawshaw, Nathan M Ennist, Colin Levy

J Am Chem Soc· July 2023

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Utilization of dietary mixed-linkage β-glucans by the Firmicute Blautia producta.
Ravindra Pal Singh, Jayashree Niharika, Raksha Thakur, Ben A Wagstaff, Gulshan Kumar, Colin W Levy

J Biol Chem· June 2023

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Structure Based Discovery of Inhibitors of CYP125 and CYP142 from Mycobacterium tuberculosis.
Mona M Katariya, Matthew Snee, Richard B Tunnicliffe, Madeline E Kavanagh, Helena I M Boshoff, Colin W Levy

Chemistry· May 2023

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A designed photoenzyme for enantioselective [2+2] cycloadditions.
Jonathan S Trimble, Rebecca Crawshaw, Florence J Hardy, Colin W Levy, Murray J B Brown

Nature· November 2022

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How a 10--Cubebol Synthase Avoids Premature Reaction Quenching to Form a Tricyclic Product at High Purity.
Joshua N Whitehead, Nicole G H Leferink, Gajendar Komati Reddy, Colin W Levy, Sam Hay

ACS Catal· October 2022

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The road to fully programmable protein catalysis.
Sarah L Lovelock, Rebecca Crawshaw, Sophie Basler, Colin Levy, David Baker

Nature· June 2022

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Structural and biochemical characterization of the prenylated flavin mononucleotide-dependent indole-3-carboxylic acid decarboxylase.
Deepankar Gahloth, Karl Fisher, Karl A P Payne, Matthew Cliff, Colin Levy

J Biol Chem· April 2022

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Engineering an efficient and enantioselective enzyme for the Morita-Baylis-Hillman reaction.
Rebecca Crawshaw, Amy E Crossley, Linus Johannissen, Ashleigh J Burke, Sam Hay, Colin Levy

Nat Chem· March 2022

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A new strategy for hit generation: Novel in cellulo active inhibitors of CYP121A1 from Mycobacterium tuberculosis via a combined X-ray crystallographic and phenotypic screening approach (XP screen).
Martyn Frederickson, Irwin R Selvam, Dimitrios Evangelopoulos, Kirsty J McLean, Mona M Katariya, Colin W Levy

Eur J Med Chem· February 2022

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UbiD domain dynamics underpins aromatic decarboxylation.
Stephen A Marshall, Karl A P Payne, Karl Fisher, Gabriel R Titchiner, Colin Levy

Nat Commun· August 2021

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A Noncanonical Tryptophan Analogue Reveals an Active Site Hydrogen Bond Controlling Ferryl Reactivity in a Heme Peroxidase.
Mary Ortmayer, Florence J Hardy, Matthew G Quesne, Karl Fisher, Colin Levy

JACS Au· July 2021

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Discovery, characterization and engineering of ligases for amide synthesis.
Michael Winn, Michael Rowlinson, Fanghua Wang, Luis Bering, Daniel Francis, Colin Levy

Nature· May 2021

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Structures of oxygen-sensing plant cysteine oxidases 4 and 5 enable targeted manipulation of their activity.
Mark D White, Laura Dalle Carbonare, Mikel Lavilla Puerta, Sergio Iacopino, Martin Edwards, Colin Levy

Proc Natl Acad Sci U S A· September 2020

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