Publications by authors named "D R Knighton"

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Discovery of the Highly Potent PI3K/mTOR Dual Inhibitor PF-04979064 through Structure-Based Drug Design.
Hengmiao Cheng, Chunze Li, Simon Bailey, Sangita M Baxi, Lance Goulet, Daniel R Knighton

ACS Med Chem Lett· January 2013

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Design and synthesis of a novel pyrrolidinyl pyrido pyrimidinone derivative as a potent inhibitor of PI3Kα and mTOR.
Phuong T Le, Hengmiao Cheng, Sacha Ninkovic, Michael Plewe, Xiaojun Huang, Daniel R Knighton

Bioorg Med Chem Lett· August 2012

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Discovery of pyrroloaminopyrazoles as novel PAK inhibitors.
Chuangxing Guo, Indrawan McAlpine, Junhu Zhang, Daniel D Knighton, Susan Kephart

J Med Chem· May 2012

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Quinazolines with intra-molecular hydrogen bonding scaffold (iMHBS) as PI3K/mTOR dual inhibitors.
Kevin K C Liu, Xiaojun Huang, Shubha Bagrodia, Jeffrey H Chen, Samantha Greasley, Dan Knighton

Bioorg Med Chem Lett· February 2011

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4-methylpteridinones as orally active and selective PI3K/mTOR dual inhibitors.
Kevin K-C Liu, Shubha Bagrodia, Simon Bailey, Hengmiao Cheng, Hui Chen, Dan Knighton

Bioorg Med Chem Lett· October 2010

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