Publications by authors named "Darwin Prockop"

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Intranasally Administered Human MSC-Derived Extracellular Vesicles Pervasively Incorporate into Neurons and Microglia in both Intact and Status Epilepticus Injured Forebrain.
Maheedhar Kodali, Olagide W Castro, Dong-Ki Kim, Alicia Thomas, Bing Shuai, Darwin J Prockop

Int J Mol Sci· December 2019

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Absence of Therapeutic Benefit of the Anti-Inflammatory Protein TSG-6 for Corneal Alkali Injury in a Rat Model.
Hosoon Choi, Casie Phillips, Joo Youn Oh, Luke Potts, Roxanne L Reger, Darwin J Prockop

Curr Eye Res· August 2019

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STAT6 induces expression of Gas6 in macrophages to clear apoptotic neutrophils and resolve inflammation.
Saroj Nepal, Chinnaswamy Tiruppathi, Yoshikazu Tsukasaki, Joseph Farahany, Manish Mittal, Darwin J Prockop

Proc Natl Acad Sci U S A· August 2019

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Macrophage Assay Predicts the Anti-inflammatory Potential of Exosomes from Human Mesenchymal Stromal Cells.
Natalia Pacienza, Ryang Hwa Lee, Eun-Hye Bae, Dong-Ki Kim, Qisong Liu, Darwin J Prockop

Mol Ther Methods Clin Dev· June 2019

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Human induced pluripotent stem cell-derived MGE cell grafting after status epilepticus attenuates chronic epilepsy and comorbidities via synaptic integration.
Dinesh Upadhya, Bharathi Hattiangady, Olagide W Castro, Bing Shuai, Maheedhar Kodali, Darwin J Prockop

Proc Natl Acad Sci U S A· January 2019

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Mesenchymal Stromal Cells Inhibit Inflammatory Lymphangiogenesis in the Cornea by Suppressing Macrophage in a TSG-6-Dependent Manner.
Hyun Beom Song, Se Yeon Park, Jung Hwa Ko, Jong Woo Park, Chang Ho Yoon, Darwin J Prockop

Mol Ther· January 2018

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Data against a Common Assumption: Xenogeneic Mouse Models Can Be Used to Assay Suppression of Immunity by Human MSCs.
Darwin J Prockop, Joo Youn Oh, Ryang Hwa Lee

Mol Ther· August 2017

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MSC-derived Extracellular Vesicles Attenuate Immune Responses in Two Autoimmune Murine Models: Type 1 Diabetes and Uveoretinitis.
Taeko Shigemoto-Kuroda, Joo Youn Oh, Dong-Ki Kim, Hyun Jeong Jeong, Se Yeon Park, Darwin J Prockop

Stem Cell Reports· May 2017

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Intranasal MSC-derived A1-exosomes ease inflammation, and prevent abnormal neurogenesis and memory dysfunction after status epilepticus.
Qianfa Long, Dinesh Upadhya, Bharathi Hattiangady, Dong-Ki Kim, Su Yeon An, Darwin J Prockop

Proc Natl Acad Sci U S A· April 2017

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The exciting prospects of new therapies with mesenchymal stromal cells.
Darwin J Prockop

Cytotherapy· January 2017

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Comparison of the anti-inflammatory effects of induced pluripotent stem cell-derived and bone marrow-derived mesenchymal stromal cells in a murine model of corneal injury.
Young In Yun, Se Yeon Park, Hyun Ju Lee, Jung Hwa Ko, Mee Kum Kim, Darwin J Prockop

Cytotherapy· January 2017

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TNFα-stimulated gene-6 (TSG6) activates macrophage phenotype transition to prevent inflammatory lung injury.
Manish Mittal, Chinnaswamy Tiruppathi, Saroj Nepal, You-Yang Zhao, Dagmara Grzych, Darwin J Prockop

Proc Natl Acad Sci U S A· December 2016

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Stanniocalcin-1 attenuates ischemic cardiac injury and response of differentiating monocytes/macrophages to inflammatory stimuli.
Arezoo Mohammadipoor, Ryang Hwa Lee, Darwin J Prockop, Thomas J Bartosh

Transl Res· November 2016

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Cancer cells enter dormancy after cannibalizing mesenchymal stem/stromal cells (MSCs).
Thomas J Bartosh, Mujib Ullah, Suzanne Zeitouni, Joshua Beaver, Darwin J Prockop

Proc Natl Acad Sci U S A· October 2016

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Scalable Production of a Multifunctional Protein (TSG-6) That Aggregates with Itself and the CHO Cells That Synthesize It.
Dong-Ki Kim, Hosoon Choi, Hidetaka Nishida, Joo Youn Oh, Carl Gregory, Darwin J Prockop

PLoS One· August 2016

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Inflammation, fibrosis, and modulation of the process by mesenchymal stem/stromal cells.
Darwin J Prockop

Matrix Biol· April 2016

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Intraperitoneally infused human mesenchymal stem cells form aggregates with mouse immune cells and attach to peritoneal organs.
Nikolay Bazhanov, Joni H Ylostalo, Thomas J Bartosh, April Tiblow, Arezoo Mohammadipoor, Darwin J Prockop

Stem Cell Res Ther· February 2016

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Mesenchymal stem/stromal cells precondition lung monocytes/macrophages to produce tolerance against allo- and autoimmunity in the eye.
Jung Hwa Ko, Hyun Ju Lee, Hyun Jeong Jeong, Mee Kum Kim, Won Ryang Wee, Darwin J Prockop

Proc Natl Acad Sci U S A· January 2016

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Chromatographically isolated CD63+CD81+ extracellular vesicles from mesenchymal stromal cells rescue cognitive impairments after TBI.
Dong-ki Kim, Hidetaka Nishida, Su Yeon An, Ashok K Shetty, Thomas J Bartosh, Darwin J Prockop

Proc Natl Acad Sci U S A· January 2016

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Hardly Tendentious--Repairing Like with Like.
Darwin J Prockop

N Engl J Med· October 2015

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An official American Thoracic Society workshop report: stem cells and cell therapies in lung biology and diseases.
Daniel J Weiss, Daniel Chambers, Adam Giangreco, Armand Keating, Darrell Kotton, Darwin J Prockop

Ann Am Thorac Soc· April 2015

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Human adipose-derived stem cells ameliorate cigarette smoke-induced murine myelosuppression via secretion of TSG-6.
Jie Xie, Hal E Broxmeyer, Dongni Feng, Kelly S Schweitzer, Ru Yi, Darwin J Prockop

Stem Cells· February 2015

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Anti-inflammatory protein tumor necrosis factor-α-stimulated protein 6 (TSG-6) promotes early gingival wound healing: an in vivo study.
Stacy R Beltran, Kathy K H Svoboda, David G Kerns, Akash Sheth, Darwin J Prockop

J Periodontol· January 2015

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MSCs derived from iPSCs with a modified protocol are tumor-tropic but have much less potential to promote tumors than bone marrow MSCs.
Qingguo Zhao, Carl A Gregory, Ryang Hwa Lee, Roxanne L Reger, Lizheng Qin, Darwin J Prockop

Proc Natl Acad Sci U S A· January 2015

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TSG-6 as a biomarker to predict efficacy of human mesenchymal stem/progenitor cells (hMSCs) in modulating sterile inflammation in vivo.
Ryang Hwa Lee, Ji Min Yu, Andrea M Foskett, Grant Peltier, John C Reneau, Darwin J Prockop

Proc Natl Acad Sci U S A· November 2014

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