Publications by authors named "David A Jans"

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The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro.
Leon Caly, Julian D Druce, Mike G Catton, David A Jans, Kylie M Wagstaff

Antiviral Res· June 2020

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The broad spectrum antiviral ivermectin targets the host nuclear transport importin α/β1 heterodimer.
Sundy N Y Yang, Sarah C Atkinson, Chunxiao Wang, Alexander Lee, Marie A Bogoyevitch, Natalie A Borg, David A Jans

Antiviral Res· May 2020

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The nuclear transport factor IPO5 revealed as a critical mediator of male germline development†.
Julia C Young, Penny A F Whiley, Jessie M Sutherland, Michael Luu, Daniel J Garama, David A Jans

Biol Reprod· October 2025

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Conformational dynamics, RNA binding, and phase separation regulate the multifunctionality of rabies virus P protein.
Stephen M Rawlinson, Shatabdi Chakraborty, Ashish Sethi, Cassandra T David, Angela R Harrison, David A Jans

Nat Commun· October 2025

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A Pilot, Randomised, Placebo-Controlled, Double-Blind Trial of a Single Oral Dose of Ivermectin for Post-Exposure Prophylaxis of SARS-CoV-2.
Kylie M Wagstaff, Mark S Stein, Alan Herschtal, Jean-Jacques Rajter, Juliana Cepelowicz Rajter, David A Jans

Pharmaceutics· September 2025

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Importin α inhibitors act against the differentiated stages of apicomplexan parasites Plasmodium falciparum and Toxoplasma gondii.
Manasi Bhambid, Sujata B Walunj, C A Anupama, Shilpi Jain, Diksha Mehta, David A Jans

J Antimicrob Chemother· February 2025

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Avermectins Inhibit Replication of Parvovirus B19 by Disrupting the Interaction Between Importin α and Non-Structural Protein 1.
Gualtiero Alvisi, Elisabetta Manaresi, Silvia Pavan, David A Jans, Kylie M Wagstaff

Viruses· February 2025

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The Ivermectin Related Compound Moxidectin Can Target Apicomplexan Importin α and Limit Growth of Malarial Parasites.
Sujata B Walunj, Geetanjali Mishra, Kylie M Wagstaff, Swati Patankar, David A Jans

Cells· January 2025

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Tumour-specific phosphorylation of serine 419 drives alpha-enolase (ENO1) nuclear export in triple negative breast cancer progression.
Morgan L Marshall, Kim Yc Fung, David A Jans, Kylie M Wagstaff

Cell Biosci· June 2024

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Piercing of the Human Parainfluenza Virus by Nanostructured Surfaces.
Samson W L Mah, Denver P Linklater, Vassil Tzanov, Phuc H Le, Chaitali Dekiwadia, David A Jans

ACS Nano· January 2024

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Increased In Vivo Exposure of N-(4-Hydroxyphenyl) Retinamide (4-HPR) to Achieve Plasma Concentrations Effective against Dengue Virus.
Alexander J Martin, David M Shackleford, Susan A Charman, Kylie M Wagstaff, Christopher J H Porter, David A Jans

Pharmaceutics· July 2023

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Respiratory Syncytial Virus Matrix Protein Is Sufficient and Necessary to Remodel Host Mitochondria in Infection.
MengJie Hu, Marie A Bogoyevitch, David A Jans

Cells· May 2023

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The Nuclear Transporter Importin 13 Can Regulate Stress-Induced Cell Death through the Clusterin/KU70 Axis.
Katarzyna A Gajewska, David A Jans, Kylie M Wagstaff

Cells· January 2023

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Conservation of Importin α Function in Apicomplexans: Ivermectin and GW5074 Target Importin α and Inhibit Parasite Growth in Culture.
Sujata B Walunj, Chunxiao Wang, Kylie M Wagstaff, Swati Patankar, David A Jans

Int J Mol Sci· November 2022

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Lyssavirus P Protein Isoforms Diverge Significantly in Subcellular Interactions Underlying Mechanisms of Interferon Antagonism.
Aaron M Brice, Ashley M Rozario, Stephen M Rawlinson, Cassandra T David, Linda Wiltzer-Bach, David A Jans

J Virol· October 2022

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Nuclear Transport of Respiratory Syncytial Virus Matrix Protein Is Regulated by Dual Phosphorylation Sites.
Reena Ghildyal, Michael N Teng, Kim C Tran, John Mills, Marco G Casarotto, David A Jans

Int J Mol Sci· July 2022

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Transcriptomic profile dataset of embryonic stem cells (Wild-type and IPO13-Knock Out) with and without oxidative stress.
Katarzyna A Gajewska, Mirana Ramialison, Kylie M Wagstaff, David A Jans

Data Brief· June 2022

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Nuclear Transporter Is Central to Efficient Neuronal Differentiation.
Katarzyna A Gajewska, John M Haynes, David A Jans

Cells· June 2022

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High-Throughput Screening to Identify Inhibitors of Importin α.
Sujata B Walunj, Manisha M Dias, Chhaminder Kaur, Kylie M Wagstaff, Vishakha Dey, David A Jans

Cells· April 2022

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Bimolecular Fluorescence Complementation: Quantitative Analysis of In Cell Interaction of Nuclear Transporter Importin α with Cargo Proteins.
Alexander Lee, Marie A Bogoyevitch, David A Jans

Methods Mol Biol· April 2022

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Selective Targeting of Protein Kinase C (PKC)-θ Nuclear Translocation Reduces Mesenchymal Gene Signatures and Reinvigorates Dysfunctional CD8 T Cells in Immunotherapy-Resistant and Metastatic Cancers.
Jenny Dunn, Robert D McCuaig, Abel H Y Tan, Wen Juan Tu, Fan Wu, David A Jans

Cancers (Basel)· March 2022

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High Throughput Screening Targeting the Dengue NS3-NS5 Interface Identifies Antivirals against Dengue, Zika and West Nile Viruses.
Sundy N Y Yang, Belinda Maher, Chunxiao Wang, Kylie M Wagstaff, Johanna E Fraser, David A Jans

Cells· February 2022

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Implication of the nuclear trafficking of rabies virus P3 protein in viral pathogenicity.
Aaron M Brice, Ericka Watts, Bevan Hirst, David A Jans, Naoto Ito

Traffic· December 2021

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Respiratory Syncytial Virus Matrix Protein-Chromatin Association Is Key to Transcriptional Inhibition in Infected Cells.
Hong-Mei Li, Reena Ghildyal, Mengjie Hu, Kim C Tran, Lora M Starrs, David A Jans

Cells· October 2021

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Phenotypic Divergence of P Proteins of Australian Bat Lyssavirus Lineages Circulating in Microbats and Flying Foxes.
Celine Deffrasnes, Meng-Xiao Luo, Linda Wiltzer-Bach, Cassandra T David, Kim G Lieu, David A Jans

Viruses· May 2021

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Adenovirus Terminal Protein Contains a Bipartite Nuclear Localisation Signal Essential for Its Import into the Nucleus.
Hareth A Al-Wassiti, David R Thomas, Kylie M Wagstaff, Stewart A Fabb, David A Jans

Int J Mol Sci· March 2021

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Application of and HTS Approaches to Identify Nuclear Import Inhibitors for Venezuelan Equine Encephalitis Virus Capsid Protein: A Case Study.
Sharon Shechter, David R Thomas, David A Jans

Front Chem· December 2020

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