Publications by authors named "David J Roush"

Claim this Profile
F
Factors affecting product association as a mechanism of host-cell protein persistence in bioprocessing.
Young Hoon Oh, Matthew L Becker, Kerri M Mendola, Leila H Choe, Lie Min, David J Roush

Biotechnol Bioeng· April 2024

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
M
Mechanistic model-based characterization of size-exclusion-mixed-mode resins for removal of monoclonal antibody fragments.
Scott H Altern, Andrew J Kocot, Jacob P LeBarre, Cristiana Boi, Michael W Phillips, David J Roush

J Chromatogr A· March 2024

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
I
Identification and characterization of CHO host-cell proteins in monoclonal antibody bioprocessing.
Young Hoon Oh, Kerri M Mendola, Leila H Choe, Lie Min, Ashton R Lavoie, David J Roush

Biotechnol Bioeng· January 2024

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
C
Characterization and implications of host-cell protein aggregates in biopharmaceutical processing.
Young Hoon Oh, Matthew L Becker, Kerri M Mendola, Leila H Choe, Lie Min, David J Roush

Biotechnol Bioeng· April 2023

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
Towards continuous mAb purification: Clearance of host cell proteins from CHO cell culture harvests via "flow-through affinity chromatography" using peptide-based adsorbents.
Sobhana Alekhya Sripada, Wenning Chu, Taufika Islam Williams, Matthew A Teten, Brian J Mosley, David J Roush

Biotechnol Bioeng· July 2022

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Scale-up issues for commercial depth filters in bioprocessing.
Negin Nejatishahidein, Minyoung Kim, Seon Y Jung, Ehsan E Borujeni, Lara Fernandez-Cerezo, David J Roush

Biotechnol Bioeng· April 2022

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
The measurement and control of high-risk host cell proteins for polysorbate degradation in biologics formulation.
Xuanwen Li, Fengqiang Wang, Hong Li, Douglas D Richardson, David J Roush

Antib Ther· January 2022

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
P
Probing IgG1 F-Multimodal Nanoparticle Interactions: A Combined Nuclear Magnetic Resonance and Molecular Dynamics Simulations Approach.
Ronak B Gudhka, Mayank Vats, Camille L Bilodeau, Scott A McCallum, Mark A McCoy, David J Roush

Langmuir· October 2021

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
B
Behavior of Water Near Multimodal Chromatography Ligands and Its Consequences for Modulating Protein-Ligand Interactions.
Camille L Bilodeau, Edmond Y Lau, David J Roush, Mark A Snyder, Steven M Cramer

J Phys Chem B· June 2021

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
I
Identification of preferred multimodal ligand-binding regions on IgG1 F using nuclear magnetic resonance and molecular dynamics simulations.
Ronak B Gudhka, Camille L Bilodeau, Scott A McCallum, Mark A McCoy, David J Roush

Biotechnol Bioeng· February 2021

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
E
Effectiveness of host cell protein removal using depth filtration with a filter containing diatomaceous earth.
Negin Nejatishahidein, Ehsan E Borujeni, David J Roush, Andrew L Zydney

Biotechnol Prog· November 2020

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
A direct RT qPCR method for quantification of retrovirus-like particles in biopharmaceutical production with CHO cells.
Musaddeq Hussain, William J Rayfield, David J Roush

J Pharm Biomed Anal· September 2020

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
A thermodynamic evaluation of antibody-surface interactions in multimodal cation exchange chromatography.
Ronak B Gudhka, David J Roush, Steven M Cramer

J Chromatogr A· September 2020

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Data-driven multi-objective optimization via grid compatible simplex technique and desirability approach for challenging high throughput chromatography applications.
Spyridon Konstantinidis, John P Welsh, Nigel J Titchener-Hooker, David J Roush, Ajoy Velayudhan

Biotechnol Prog· November 2018

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
I
Integrated viral clearance strategies-reflecting on the present, projecting to the future.
David J Roush

Curr Opin Biotechnol· October 2018

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Defining the mechanistic binding of viral particles to a multi-modal anion exchange resin.
Matthew R Brown, Michael S Burnham, Scott C Lute, Sarah A Johnson, Alison A Walsh, David J Roush

Biotechnol Prog· July 2018

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
E
Evaluating the effect of in-process material on the binding mechanisms of surrogate viral particles to a multi-modal anion exchange resin.
Matthew R Brown, Michael S Burnham, Sarah A Johnson, Scott C Lute, Kurt A Brorson, David J Roush

J Biotechnol· February 2018

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
C
C metabolic flux analysis identifies limitations to increasing specific productivity in fed-batch and perfusion.
Neil Templeton, Sen Xu, David J Roush, Hao Chen

Metab Eng· November 2017

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
The step-wise framework to design a chromatography-based hydrophobicity assay for viral particles.
Sarah A Johnson, Alison Walsh, Matthew R Brown, Scott C Lute, David J Roush

J Chromatogr B Analyt Technol Biomed Life Sci· September 2017

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
A step-wise approach to define binding mechanisms of surrogate viral particles to multi-modal anion exchange resin in a single solute system.
Matthew R Brown, Sarah A Johnson, Kurt A Brorson, Scott C Lute, David J Roush

Biotechnol Bioeng· July 2017

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
H
High throughput chromatography strategies for potential use in the formal process characterization of a monoclonal antibody.
Matthew G Petroff, Haiying Bao, John P Welsh, Miranda van Beuningen-de Vaan, Jennifer M Pollard, David J Roush

Biotechnol Bioeng· June 2016

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
P
Prediction of viral filtration performance of monoclonal antibodies based on biophysical properties of feed.
William J Rayfield, David J Roush, Rebecca A Chmielowski, Nihal Tugcu, Shehab Barakat

Biotechnol Prog· April 2016

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
Application of simplex-based experimental optimization to challenging bioprocess development problems: Case studies in downstream processing.
Spyridon Konstantinidis, John P Welsh, David J Roush, Ajoy Velayudhan

Biotechnol Prog· March 2016

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
L
Limits in virus filtration capability? Impact of virus quality and spike level on virus removal with xenotropic murine leukemia virus.
David J Roush, Adam Myrold, Michael S Burnham, Joseph V And, Joseph V Hughes

Biotechnol Prog· December 2015

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
Targeted purification development enabled by computational biophysical modeling.
Francis K Insaidoo, Michael A Rauscher, Shepard J Smithline, Niels C Kaarsholm, Bradley P Feuston, David J Roush

Biotechnol Prog· December 2015

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis