Publications by authors named "David Lefer"

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Renal denervation improves cardiac function and exercise duration in a miniswine model of heart failure with preserved ejection fraction.
David J Lefer, Thomas E Sharp, Amy L Scarborough, Amelia G Haydel, Sanjiv J Shah

Eur J Heart Fail· October 2025

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Hydrogen Sulfide Deficiency and Therapeutic Targeting in Cardiometabolic HFpEF: Evidence for Synergistic Benefit With GLP-1/Glucagon Agonism.
Jake E Doiron, Mahmoud H Elbatreek, Huijing Xia, Xiaoman Yu, Natalie D Gehred, David J Lefer

JACC Basic Transl Sci· October 2025

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Dysregulated Protein -Nitrosylation Promotes Nitrosative Stress and Disease Progression in Heart Failure With Preserved Ejection Fraction.
Zhen Li, Kyle B LaPenna, Natalie D Gehred, Xiaoman Yu, W H Wilson Tang, David J Lefer

Circ Res· October 2025

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Integrated Systems Biology Identifies Disruptions in Mitochondrial Function and Metabolism as Key Contributors to HFpEF.
Andrew A Gibb, Kyle LaPenna, Ryan B Gaspar, Nadina R Latchman, Yinfei Tan, David J Lefer

JACC Basic Transl Sci· September 2025

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Unlocking Mitochondrial Potential: DWORF to the Rescue in Heart Failure.
Mahmoud H Elbatreek, David J Lefer

Circ Res· September 2025

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Low Dose GLP-1 Therapy Attenuates Pathological Cardiac and Hepatic Remodelling in HFpEF Independent of Weight Loss.
Mahmoud H Elbatreek, Zhen Li, Xiaoman Yu, Natalie D Gehred, Tatiana Gromova, David J Lefer

bioRxiv· September 2025

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Ultrasound Renal Denervation Attenuates Early Cardiac Remodeling After Acute Myocardial Infarction in a Swine Model of Hypertensions and Dyslipidemia: A Pilot Study.
Thomas E Sharp, Amy L Scarborough, Amelia G Haydel, J Stephen Jenkins, Marloe Prince, David J Lefer

Clin Transl Sci· August 2025

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Impact of Voluntary Exercise on Systemic Inflammation in a 2? Hit Model of Heart Failure With Preserved Ejection Fraction.
Heather Quiriarte, Eunhan Cho, Youyoung Kim, Jake E Doiron, Gregory Davis, David J Lefer

J Am Heart Assoc· February 2025

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Hydrogen Sulfide Deficiency and Therapeutic Targeting in Cardiometabolic HFpEF: Evidence for Synergistic Benefit with GLP-1/Glucagon Agonism.
Jake E Doiron, Mahmoud H Elbatreek, Huijing Xia, Xiaoman Yu, Natalie D Gehred, David J Lefer

bioRxiv· January 2025

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Protective role of 3-mercaptopyruvate sulfurtransferase (MPST) in the development of metabolic syndrome and vascular inflammation.
Paraskevas Zampas, Zhen Li, Antonia Katsouda, Aimilia Varela, Stelios Psarras, David J Lefer

Pharmacol Res· January 2025

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Cardiomyocyte myofilament function in common animal models of heart failure with preserved ejection fraction.
Vivek P Jani, Navid Koleini, Axel J Fenwick, Thomas E Sharp, Traci T Goodchild, David J Lefer

J Mol Cell Cardiol· December 2024

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Alcohol-induced gut microbial reorganization and associated overproduction of phenylacetylglutamine promotes cardiovascular disease.
Zhen Li, Min Gu, Aline Zaparte, Xiaoming Fu, Kala Mahen, David J Lefer

Nat Commun· December 2024

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Dysregulation of Nitrosylation Dynamics Promotes Nitrosative Stress and Contributes to Cardiometabolic Heart Failure with Preserved Ejection Fraction.
Zhen Li, Kyle B LaPenna, Natalie D Gehred, Xiaoman Yu, W H Wilson Tang, David J Lefer

bioRxiv· December 2024

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Exercise Therapy Rescues Skeletal Muscle Dysfunction and Exercise Intolerance in Cardiometabolic HFpEF.
Heather Quiriarte, Robert C Noland, James E Stampley, Gregory Davis, Zhen Li, David J Lefer

JACC Basic Transl Sci· December 2024

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Adjunctive therapy with an oral HS donor provides additional therapeutic benefit beyond SGLT2 inhibition in cardiometabolic heart failure with preserved ejection fraction.
Jake E Doiron, Huijing Xia, Xiaoman Yu, Alexandra R Nevins, Kyle B LaPenna, David J Lefer

Br J Pharmacol· November 2024

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A Bifunctional Sulfide Donor Approach for Ischemic Stroke: Leveraging Butylphthalide as a Carrier for Sulfide Prodrug.
Wen Peng, Jianru Liu, Zhen Li, Yuanan Wang, Yangqian Sun, David J Lefer

J Med Chem· November 2024

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A Highly Atom-Efficient Prodrug Approach to Generate Synergy between HS and Nonsteroidal Anti-inflammatory Drugs and Improve Safety.
Wen Peng, Lixiao Qin, Tianci Wang, Yangqian Sun, Zhen Li, David J Lefer

J Med Chem· October 2024

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Rapid onset fibrotic remodeling and ventricular dysfunction induced by phenylephrine involve targeted reprogramming of myocyte and fibroblast transcriptomes.
Todd H Kimball, Tatiana Gromova, Natalie D Gehred, Douglas J Chapski, Ke Wang, David J Lefer

bioRxiv· October 2024

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Nitric oxide donors rescue metabolic and mitochondrial dysfunction in obese Alzheimer's model.
Timothy D Allerton, James E Stampley, Zhen Li, Xiaoman Yu, Heather Quiariate, David J Lefer

Sci Rep· October 2024

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Integrated systems biology identifies disruptions in mitochondrial function and metabolism as key contributors to heart failure with preserved ejection fraction (HFpEF).
Andrew A Gibb, Kyle LaPenna, Ryan B Gaspar, Nadina R Latchman, Yinfei Tan, David J Lefer

bioRxiv· October 2024

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"Circulating Inflammation" and the Plasma Proteome in Heart Failure With Preserved Ejection Fraction.
Thomas M Vondriska, David J Lefer

JACC Basic Transl Sci· September 2024

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Early Renal Denervation Attenuates Cardiac Dysfunction in Heart Failure With Preserved Ejection Fraction.
Jake E Doiron, Zhen Li, Xiaoman Yu, Kyle B LaPenna, Heather Quiriarte, David J Lefer

J Am Heart Assoc· February 2024

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Cardiovascular dysfunction induced by combined exposure to nicotine inhalation and high-fat diet.
Anna K Whitehead, Zhen Li, Kyle B LaPenna, Nour Abbes, Thomas E Sharp, David J Lefer

Am J Physiol Heart Circ Physiol· January 2024

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Common Heart Failure With Preserved Ejection Fraction Animal Models Yield Disparate Myofibril Mechanics.
Axel J Fenwick, Vivek P Jani, D Brian Foster, Thomas E Sharp, Traci T Goodchild, David J Lefer

J Am Heart Assoc· January 2024

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sGC Stimulation Saves the Diabetic Heart: Red Blood Cells to the Rescue.
Andreas Papapetropoulos, David J Lefer

JACC Basic Transl Sci· August 2023

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