Publications by authors named "David R Spigel"

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Five-Year Survival Outcomes From the PACIFIC Trial: Durvalumab After Chemoradiotherapy in Stage III Non-Small-Cell Lung Cancer.
David R Spigel, Corinne Faivre-Finn, Jhanelle E Gray, David Vicente, David Planchard, Luis Paz-Ares, Johan F Vansteenkiste, Marina C Garassino, Rina Hui, Xavier Quantin

April 2022

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Digital Versus Manual PD-L1 Scoring in Advanced NSCLC From the IMpower110 and IMpower150 Trials.
Roy S Herbst, Hen Prizant, Daniel Ruderman, Jake Conway, John Shamshoian, David R Spigel

J Thorac Oncol· December 2025

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Clinical Presentation of Deletions in Real-World Settings: Lessons for the Clinical Development of Novel Targeted Therapies.
Jordan T Best, Xiaotong Fu, Sripraharsha S Jampana Raju, Daniel Luckett, Dan Schlauch, David R Spigel

JCO Precis Oncol· December 2025

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Impact of community recruitment and inclusion initiatives on enrollment in the biomarker-driven MyTACTIC trial.
Richard M Zuniga, Ari VanderWalde, Lee S Schwartzberg, David R Spigel, Luke Passler

Future Oncol· December 2025

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INDUCE-3: A randomized Phase II/III study of first-line feladilimab plus pembrolizumab in patients with recurrent/metastatic head and neck squamous cell carcinoma.
Danny Rischin, Aaron R Hansen, Ezra E W Cohen, Makoto Tahara, Kevin J Harrington, David R Spigel

Clin Cancer Res· December 2025

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Circulating tumor DNA monitoring and blood tumor mutational burden in patients with metastatic solid tumors treated with atezolizumab.
Charles Swanton, Russell W Madison, Candice Francheska B Tambaoan, Funda Meric-Bernstam, Christopher J Sweeney, David R Spigel

Mol Oncol· November 2025

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Two Phase II Trials of Adavosertib, a Wee1 Inhibitor with Docetaxel or Carboplatin plus Pemetrexed in Non-small-cell Lung Cancer.
Melissa L Johnson, Shaker R Dakhil, J Thaddeus Beck, Ahad Sadiq, Smitha Menon, David R Spigel

Target Oncol· November 2025

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Adjuvant chemotherapy for stage IA-IIA non-squamous, non-small-cell lung cancer identified as molecular high-risk by a 14-gene expression profile (AIM-HIGH): an international, randomised, phase 3 trial.
David R Spigel, Virginie Westeel, Ian C Anderson, Laurent Greillier, Florian Guisier

Lancet Respir Med· October 2025

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TNG260 Is a Small-Molecule CoREST Inhibitor That Sensitizes STK11-Mutant Tumors to Anti-PD-1 Immunotherapy.
Leanne G Ahronian, Soumyadip Sahu, Minjie Zhang, Ayushi S Patel, Ke Geng, David R Spigel

Cancer Res· October 2025

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ctDNA Analysis in ERBB2-Amplified Colorectal Cancer: Biomarker Analysis of the MyPathway Trial.
Funda Meric-Bernstam, Kanwal Pratap Singh Raghav, Christopher J Sweeney, Charles Swanton, David R Spigel

Clin Cancer Res· July 2025

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Concurrent and Consolidative Carboplatin Plus Nab-Paclitaxel or Paclitaxel in Locally Advanced NSCLC: A Multicenter, Randomized Clinical Trial.
Yuanyuan Zhang, Aaron M Laine, Puneeth Iyengar, Kenneth D Westover, Jonathan E Dowell, David R Spigel

Int J Radiat Oncol Biol Phys· June 2025

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Reply to P. de Boissieu et al.
David R Spigel, Afshin Dowlati, Yuanbin Chen, Alejandro Navarro, James Chih-Hsin Yang

J Clin Oncol· January 2025

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Open-Label, Multicenter, Phase I Study to Assess Safety and Tolerability of Adavosertib Plus Durvalumab in Patients with Advanced Solid Tumors.
Manish R Patel, Gerald S Falchook, Judy S Wang, Esteban Rodrigo Imedio, Sanjeev Kumar, David R Spigel

Target Oncol· January 2025

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Belzutifan plus cabozantinib as first-line treatment for patients with advanced clear-cell renal cell carcinoma (LITESPARK-003): an open-label, single-arm, phase 2 study.
Toni K Choueiri, Jaime R Merchan, Robert Figlin, David F McDermott, Edward Arrowsmith, David R Spigel

Lancet Oncol· January 2025

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Adavosertib in Combination with Olaparib in Patients with Refractory Solid Tumors: An Open-Label, Dose-Finding, and Dose-Expansion Phase Ib Trial.
Erika P Hamilton, Gerald S Falchook, Judy S Wang, Siqing Fu, Amit M Oza, David R Spigel

Target Oncol· November 2024

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A Phase Ib/II Randomized Clinical Trial of Oleclumab with or without Durvalumab plus Chemotherapy in Patients with Metastatic Pancreatic Ductal Adenocarcinoma.
Andrew L Coveler, Matthew J Reilley, Mark Zalupski, Teresa Macarulla, Christos Fountzilas, David R Spigel

Clin Cancer Res· October 2024

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Durvalumab after Chemoradiotherapy in Limited-Stage Small-Cell Lung Cancer.
Ying Cheng, David R Spigel, Byoung Chul Cho, Konstantin K Laktionov, Jian Fang

N Engl J Med· October 2024

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Personalized Therapy Selection by Integration of Molecular Cancer Classification by the 92-Gene Assay and Tumor Profiling in Patients With Cancer of Unknown Primary.
Harry E Fuentes Bayne, Pashtoon M Kasi, Li Ma, Lowell L Hart, Jenna Wong, David R Spigel

JCO Precis Oncol· September 2024

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RESILIENT Part 2: A Randomized, Open-Label Phase III Study of Liposomal Irinotecan Versus Topotecan in Adults With Relapsed Small Cell Lung Cancer.
David R Spigel, Afshin Dowlati, Yuanbin Chen, Alejandro Navarro, James Chih-Hsin Yang

J Clin Oncol· July 2024

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Therapy for Stage IV Non-Small Cell Lung Cancer With Driver Alterations: ASCO Living Guideline, Version 2023.3.
Ishmael A Jaiyesimi, Natasha B Leighl, Nofisat Ismaila, Krishna Alluri, Narjust Florez, David R Spigel

J Clin Oncol· April 2024

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Therapy for Stage IV Non-Small Cell Lung Cancer Without Driver Alterations: ASCO Living Guideline, Version 2023.3.
Ishmael A Jaiyesimi, Natasha B Leighl, Nofisat Ismaila, Krishna Alluri, Narjust Florez, David R Spigel

J Clin Oncol· April 2024

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A phase 2 study of AZD4635 in combination with durvalumab or oleclumab in patients with metastatic castration-resistant prostate cancer.
Gerald S Falchook, James Reeves, Sunil Gandhi, David R Spigel, Edward Arrowsmith

Cancer Immunol Immunother· March 2024

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Modified FOLFOX6 plus bevacizumab with and without nivolumab for first-line treatment of metastatic colorectal cancer: phase 2 results from the CheckMate 9X8 randomized clinical trial.
Heinz-Josef Lenz, Aparna Parikh, David R Spigel, Allen L Cohn, Takayuki Yoshino

J Immunother Cancer· March 2024

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A randomized phase II study of metronomic cyclophosphamide and methotrexate (CM) with or without bevacizumab in patients with advanced breast cancer.
Erica L Mayer, Nabihah Tayob, Siyang Ren, Jennifer J Savoie, David R Spigel

Breast Cancer Res Treat· February 2024

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Canakinumab as Adjuvant Therapy in Patients With Completely Resected Non-Small-Cell Lung Cancer: Results From the CANOPY-A Double-Blind, Randomized Clinical Trial.
Edward B Garon, Shun Lu, Yasushi Goto, Pedro De Marchi, Luis Paz-Ares, David R Spigel

J Clin Oncol· January 2024

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MyPathway Human Epidermal Growth Factor Receptor 2 Basket Study: Pertuzumab + Trastuzumab Treatment of a Tissue-Agnostic Cohort of Patients With Human Epidermal Growth Factor Receptor 2-Altered Advanced Solid Tumors.
Christopher J Sweeney, John D Hainsworth, Ron Bose, Howard A Burris, Razelle Kurzrock, David R Spigel

J Clin Oncol· January 2024

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