Publications by authors named "F Cumin"

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Discovery of 4-((2,4)-4-Ethoxy-1-((5-methoxy-7-methyl-1-indol-4-yl)methyl)piperidin-2-yl)benzoic Acid (LNP023), a Factor B Inhibitor Specifically Designed To Be Applicable to Treating a Diverse Array of Complement Mediated Diseases.
Nello Mainolfi, Takeru Ehara, Rajeshri G Karki, Karen Anderson, Aengus Mac Sweeney, Frederic Cumin

J Med Chem· June 2020

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Structure-Guided Design of Substituted Biphenyl Butanoic Acid Derivatives as Neprilysin Inhibitors.
Toshio Kawanami, Rajeshri G Karki, Emma Cody, Qian Liu, Guiqing Liang, Frederic Cumin

ACS Med Chem Lett· February 2020

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Design, Synthesis, and Preclinical Characterization of Selective Factor D Inhibitors Targeting the Alternative Complement Pathway.
Rajeshri G Karki, James Powers, Nello Mainolfi, Karen Anderson, David B Belanger, Frederic Cumin

J Med Chem· May 2019

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Small-molecule factor B inhibitor for the treatment of complement-mediated diseases.
Anna Schubart, Karen Anderson, Nello Mainolfi, Holger Sellner, Takeru Ehara, Frederic Cumin

Proc Natl Acad Sci U S A· April 2019

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Discovery and Design of First Benzylamine-Based Ligands Binding to an Unlocked Conformation of the Complement Factor D.
Anna Vulpetti, Nils Ostermann, Stefan Randl, Taeyoung Yoon, Aengus Mac Sweeney, Frederic Cumin

ACS Med Chem Lett· May 2018

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