Publications by authors named "Frans Hogervorst"

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Genome-wide association study of 398,238 women unveils seven loci associated with high-grade serous ovarian cancer.
Daniel R Barnes, Jonathan P Tyrer, Joe Dennis, Goska Leslie, Manjeet K Bolla, Frans B L Hogervorst

NPJ Genom Med· November 2025

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Author Correction: Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast-ovarian cancer susceptibility locus.
Kate Lawrenson, Siddhartha Kar, Karen McCue, Karoline Kuchenbaeker, Kyriaki Michailidou, Frans B L Hogervorst

Nat Commun· September 2025

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Cohort profile: a nationwide study in Dutch c.1100delC families using the infrastructure of the HEreditary Breast and Ovarian cancer study Netherlands - Hebon-CHEK2.
Maartje A C Schreurs, Muriel A Adank, Antoinette Hollestelle, Rosa de Groot, Denise J Stommel-Jenner, Frans B L Hogervorst

BMJ Open· October 2024

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Does a proactive procedure lead to a higher uptake of predictive testing in families with a pathogenic BRCA1/BRCA2 variant? A family cancer clinic evaluation.
Fred H Menko, Sophie L van der Velden, Diana N Griffioen, Daoud Ait Moha, Kiki N Jeanson, Frans B L Hogervorst

J Genet Couns· June 2024

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A likelihood ratio approach for utilizing case-control data in the clinical classification of rare sequence variants: application to and .
Maria Zanti, Denise G O'Mahony, Michael T Parsons, Hongyan Li, Joe Dennis, Frans B L Hogervorst

Hum Mutat· May 2024

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Optimized whole-genome sequencing workflow for tumor diagnostics in routine pathology practice.
Kris G Samsom, Linda J W Bosch, Luuk J Schipper, Daoin Schout, Paul Roepman, Frans B L Hogervorst

Nat Protoc· March 2024

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Large-scale genome-wide association study of 398,238 women unveils seven novel loci associated with high-grade serous epithelial ovarian cancer risk.
Daniel R Barnes, Jonathan P Tyrer, Joe Dennis, Goska Leslie, Manjeet K Bolla, Frans B L Hogervorst

medRxiv· March 2024

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Impact of genetic counseling strategy on diagnostic yield and workload for genome-sequencing-based tumor diagnostics.
Roelof Koster, Luuk J Schipper, Noor A A Giesbertz, Daphne van Beek, Matías Mendeville, Frans B L Hogervorst

Genet Med· February 2024

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Identifying the BRCA1 c.-107A > T variant in Dutch patients with a tumor BRCA1 promoter hypermethylation.
Vincent M T de Jong, Roelof Pruntel, Tessa G Steenbruggen, Fonnet E Bleeker, Petra Nederlof, Frans B L Hogervorst

Fam Cancer· April 2023

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Challenges in breast cancer genetic testing. A call for novel forms of multidisciplinary care and long-term evaluation.
Fred H Menko, Kim Monkhorst, Frans B L Hogervorst, Efraim H Rosenberg, Muriel A Adank

Crit Rev Oncol Hematol· August 2022

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Uncovering the Contribution of Moderate-Penetrance Susceptibility Genes to Breast Cancer by Whole-Exome Sequencing and Targeted Enrichment Sequencing of Candidate Genes in Women of European Ancestry.
Martine Dumont, Nana Weber-Lassalle, Charles Joly-Beauparlant, Corinna Ernst, Arnaud Droit, Frans B L Hogervorst

Cancers (Basel)· July 2022

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Breast cancer risks associated with missense variants in breast cancer susceptibility genes.
Leila Dorling, Sara Carvalho, Jamie Allen, Michael T Parsons, Cristina Fortuno, Frans B L Hogervorst

Genome Med· May 2022

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The predictive ability of the 313 variant-based polygenic risk score for contralateral breast cancer risk prediction in women of European ancestry with a heterozygous BRCA1 or BRCA2 pathogenic variant.
Inge M M Lakeman, Alexandra J van den Broek, Juliën A M Vos, Daniel R Barnes, Julian Adlard, Frans B L Hogervorst

Genet Med· September 2021

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Author Correction: A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers.
Juliette Coignard, Michael Lush, Jonathan Beesley, Tracy A O'Mara, Joe Dennis, Frans B L Hogervorst

Nat Commun· May 2021

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Breast Cancer Risk Genes - Association Analysis in More than 113,000 Women.

N Engl J Med· February 2021

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A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers.
Juliette Coignard, Michael Lush, Jonathan Beesley, Tracy A O'Mara, Joe Dennis, Frans B L Hogervorst

Nat Commun· February 2021

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Clustering of known low and moderate risk alleles rather than a novel recessive high-risk gene in non-BRCA1/2 sib trios affected with breast cancer.
Florentine S Hilbers, Peter J van 't Hof, Caro M Meijers, Hailiang Mei, Kyriaki Michailidou, Frans B L Hogervorst

Int J Cancer· November 2020

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Polygenic risk scores and breast and epithelial ovarian cancer risks for carriers of BRCA1 and BRCA2 pathogenic variants.
Daniel R Barnes, Matti A Rookus, Lesley McGuffog, Goska Leslie, Thea M Mooij, Frans B L Hogervorst

Genet Med· October 2020

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The uptake of predictive DNA testing in 40 families with a pathogenic BRCA1/BRCA2 variant. An evaluation of the proband-mediated procedure.
Fred H Menko, Kiki N Jeanson, Eveline M A Bleiker, Carla W M van Tiggelen, Frans B L Hogervorst

Eur J Hum Genet· August 2020

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Characterization of the Cancer Spectrum in Men With Germline BRCA1 and BRCA2 Pathogenic Variants: Results From the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA).
Valentina Silvestri, Goska Leslie, Daniel R Barnes, , Bjarni A Agnarsson, Frans B L Hogervorst

JAMA Oncol· August 2020

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Transcriptome-wide association study of breast cancer risk by estrogen-receptor status.
Helian Feng, Alexander Gusev, Bogdan Pasaniuc, Lang Wu, Jirong Long, Frans B L Hogervorst

Genet Epidemiol· July 2020

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BRCAness digitalMLPA profiling predicts benefit of intensified platinum-based chemotherapy in triple-negative and luminal-type breast cancer.
Esther H Lips, Anne Benard-Slagter, Mark Opdam, Caroline E Scheerman, Jelle Wesseling, Frans B L Hogervorst

Breast Cancer Res· July 2020

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Genome-wide association study identifies 32 novel breast cancer susceptibility loci from overall and subtype-specific analyses.
Haoyu Zhang, Thomas U Ahearn, Julie Lecarpentier, Daniel Barnes, Jonathan Beesley, Frans B L Hogervorst

Nat Genet· June 2020

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Association of Genomic Domains in and with Prostate Cancer Risk and Aggressiveness.
Vivek L Patel, Evan L Busch, Tara M Friebel, Angel Cronin, Goska Leslie, Frans B L Hogervorst

Cancer Res· February 2020

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Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genes.
Laura Fachal, Hugues Aschard, Jonathan Beesley, Daniel R Barnes, Jamie Allen, Frans B L Hogervorst

Nat Genet· January 2020

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