Publications by authors named "Gerard Sergeant"

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Distinct domains of LINGO1 control surface expression and biophysical properties of large conductance Ca- and voltage-activated potassium (BK) channels.
Yaly Al Kawadri, Heather McClafferty, Srikanth Dudem, Kaneez E Rabab, Keith D Thornbury, Gerard P Sergeant

J Biol Chem· September 2025

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Neuroinflammatory Consequences of Rhinovirus Infection in Human Epithelial and Neuronal Models.
Orla M Dunne, Nicola A M Roe, Aurélie Mousnier, S Lorraine Martin, Gerard P Sergeant

Lung· September 2025

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Unravelling the Role of Post-Junctional M2 Muscarinic Receptors in Cholinergic Nerve-Mediated Contractions of Airway Smooth Muscle.
Srijit Ghosh, Tuleen Alkawadri, Mark A Hollywood, Keith D Thornbury, Gerard P Sergeant

Int J Mol Sci· June 2025

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ANO1 channels are expressed in mouse urethral smooth muscle but do not contribute to agonist or neurally evoked contractions.
Neha Gupta, Salah A Baker, Kenton M Sanders, Kaneez E Rabab, Denzel Kf Thean, Gerard P Sergeant

Sci Rep· May 2025

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K7 channels modulate tension and calcium signaling in mouse corpus cavernosum.
Mitchell Mercer, Mark A Hollywood, Gerard P Sergeant, Keith D Thornbury

Am J Physiol Cell Physiol· March 2025

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Role of voltage-gated Ca channels and Ano1 Ca-activated Cl channels in M2 muscarinic receptor-dependent contractions of murine airway smooth muscle.
Srijit Ghosh, Tuleen Alkawadri, Lorcan P McGarvey, Mark A Hollywood, Keith D Thornbury, Gerard P Sergeant

Am J Physiol Lung Cell Mol Physiol· February 2025

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Interstitial cell of Cajal-like cells (ICC-LC) exhibit dynamic spontaneous activity but are not functionally innervated in mouse urethra.
Neha Gupta, Salah A Baker, Kenton M Sanders, Caoimhin S Griffin, Gerard P Sergeant

Cell Calcium· November 2024

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Regulation of nerve-evoked contractions of the murine vas deferens.
Pei Yee Wong, Zhihui Fong, Mark A Hollywood, Keith D Thornbury, Gerard P Sergeant

Purinergic Signal· October 2024

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Evidence of an excitatory purinergic innervation in mouse corpus cavernosum smooth muscle.
Xin Rui Lim, Mitchell Mercer, Osama F Harraz, Mark A Hollywood, Gerard P Sergeant

J Sex Med· October 2024

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House dust mite allergens induce Ca signalling and alarmin responses in asthma airway epithelial cells.
Xuan Ouyang, James A Reihill, Lisa E J Douglas, Orla M Dunne, Gerard P Sergeant

Biochim Biophys Acta Mol Basis Dis· April 2024

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TRPV2 modulates mechanically Induced ATP Release from Human bronchial epithelial cells.
Orla M Dunne, S Lorraine Martin, Gerard P Sergeant, Daniel F McAuley, Cecilia M O'Kane

Respir Res· April 2024

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Modulation of fast sodium current in airway smooth muscle cells by exchange protein directly activated by cAMP.
Ruth M Matthews, Eamonn Bradley, Mark A Hollywood, Fionnuala T Lundy, Lorcan P McGarvey, Gerard P Sergeant

Am J Physiol Cell Physiol· January 2024

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Blockade of Kv7 channels reverses the inhibitory effects of exchange protein directly activated by cAMP activation on purinergic contractions of the murine detrusor.
Zhihui Fong, Anshika Lall, Nicolas D Mullins, L Fernando Santana, Mark A Hollywood, Gerard P Sergeant

Basic Clin Pharmacol Toxicol· July 2023

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The TMEM16A blockers benzbromarone and MONNA cause intracellular Ca-release in mouse bronchial smooth muscle cells.
Ritu Dwivedi, Bernard T Drumm, Tuleen Alkawadri, S Lorraine Martin, Gerard P Sergeant

Eur J Pharmacol· May 2023

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Oxidation modulates LINGO2-induced inactivation of large conductance, Ca-activated potassium channels.
Srikanth Dudem, Pei Xin Boon, Nicholas Mullins, Heather McClafferty, Michael J Shipston, Gerard P Sergeant

J Biol Chem· March 2023

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Contribution of Postjunctional M2 Muscarinic Receptors to Cholinergic Nerve-Mediated Contractions of Murine Airway Smooth Muscle.
Tuleen Alkawadri, Lorcan P McGarvey, N D Mullins, Mark A Hollywood, Keith D Thornbury, Gerard P Sergeant

Function (Oxf)· January 2023

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M2 Muscarinic Receptor-Dependent Contractions of Airway Smooth Muscle are Inhibited by Activation of β-Adrenoceptors.
Tuleen Alkawadri, Pei Yee Wong, Zhihui Fong, Fionnuala T Lundy, Lorcan P McGarvey, Gerard P Sergeant

Function (Oxf)· January 2023

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Ca -activated Cl channels (TMEM16A) underlie spontaneous electrical activity in isolated mouse corpus cavernosum smooth muscle cells.
Xin Rui Lim, Bernard T Drumm, Gerard P Sergeant, Mark A Hollywood, Keith D Thornbury

Physiol Rep· November 2022

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Functional expression of Na1.7 channels in freshly dispersed mouse bronchial smooth muscle cells.
Ruth M Matthews, Eamonn Bradley, Caoimhin S Griffin, Xin Rui Lim, Nicolas D Mullins, Gerard P Sergeant

Am J Physiol Cell Physiol· September 2022

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Modulation of carbachol-induced Ca oscillations in airway smooth muscle cells by PGE.
Leanna M Morgan, S Lorraine Martin, Nicholas D Mullins, Mark A Hollywood, Keith D Thornbury, Gerard P Sergeant

Cell Calcium· May 2022

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Fast voltage-dependent sodium (Na ) currents are functionally expressed in mouse corpus cavernosum smooth muscle cells.
Xin Rui Lim, Eamonn Bradley, Caoimhin S Griffin, Mark A Hollywood, Gerard P Sergeant

Br J Pharmacol· March 2022

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Calcium-Activated K Channels (K) and Therapeutic Implications.
Srikanth Dudem, Gerard P Sergeant, Keith D Thornbury, Mark A Hollywood

Handb Exp Pharmacol· September 2021

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Regulation of P2X1 receptors by modulators of the cAMP effectors PKA and EPAC.
Zhihui Fong, Caoimhín S Griffin, Roddy J Large, Mark A Hollywood, Keith D Thornbury, Gerard P Sergeant

Proc Natl Acad Sci U S A· September 2021

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Role of Ano1 Ca-activated Cl channels in generating urethral tone.
Bernard T Drumm, Keith D Thornbury, Mark A Hollywood, Gerard P Sergeant

Am J Physiol Renal Physiol· April 2021

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Igniting Ca sparks with TRPML1.
Gerard P Sergeant, Mark A Hollywood, Keith D Thornbury

Proc Natl Acad Sci U S A· December 2020

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