Publications by authors named "Graeme Conn"

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Design, Synthesis, and Evaluation of Novel Inhibitors of Aminoglycoside-Resistance 16S Ribosomal RNA Methyltransferases.
Benjamin E Deprez, Debayan Dey, Natalia Zelinskaya, Erika E Csatary, Qimin Winnie Yang, Graeme L Conn

ChemMedChem· December 2025

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Molecular basis of tRNA substrate recognition and modification by the atypical SPOUT methyltransferase Trm10.
Suparno Nandi, Sarah E Strassler, Debayan Dey, Aiswarya Krishnamohan, George M Harris, Graeme L Conn

bioRxiv· December 2025

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KNexPHENIX: A PHENIX-Based Workflow for Improving Cryo-EM and Crystallographic Structural Models.
Suparno Nandi, Graeme L Conn

bioRxiv· October 2025

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Discovery of First-in-Class Inhibitors Targeting a Pathogen-Associated Aminoglycoside-Resistance 16S rRNA Methyltransferase.
Debayan Dey, Benjamin E Deprez, Natalia Zelinskaya, Jose M Castro, William M Wuest, Graeme L Conn

ACS Infect Dis· August 2025

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Basis for selective drug evasion of an aminoglycoside-resistance ribosomal RNA modification.
Debayan Dey, Jacob M Mattingly, Natalia Zelinskaya, Christine M Dunham, Graeme L Conn

Nat Commun· August 2025

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Mechanism of 30S subunit recognition and modification by the conserved bacterial ribosomal RNA methyltransferase RsmI.
Mohamed I Barmada, Erin N McGinity, Suparno Nandi, Debayan Dey, Natalia Zelinskaya, Graeme L Conn

bioRxiv· August 2025

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Distant ribose 2'-O-methylation of 23S rRNA helix 69 pre-orders the capreomycin drug binding pocket at the ribosome subunit interface.
Suparno Nandi, Debayan Dey, Pooja Srinivas, Christine M Dunham, Graeme L Conn

Nucleic Acids Res· July 2025

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Regulation, structure, and activity of the MexXY efflux system.
Logan G Kavanaugh, Megan E Hinrichsen, Christine M Dunham, Graeme L Conn

Antimicrob Agents Chemother· April 2025

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Determination of MexXY-OprM substrate profile in a major efflux knockout system reveals distinct antibiotic substrate classes.
Logan G Kavanaugh, Shraddha M Hariharan, Graeme L Conn

Microbiol Spectr· March 2025

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Evading resistance at the double.
Mohamed I Barmada, Graeme L Conn

Nat Chem Biol· December 2024

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DISTANT RIBOSE 2'-O-METHYLATION OF 23S rRNA HELIX 69 PRE-ORDERS THE CAPREOMYCIN DRUG BINDING POCKET AT THE RIBOSOME SUBUNIT INTERFACE.
Suparno Nandi, Debayan Dey, Pooja Srinivas, Christine M Dunham, Graeme L Conn

bioRxiv· November 2024

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Determination of MexXY-OprM substrate profile in a major efflux knockout system reveals distinct antibiotic substrate classes.
Logan G Kavanaugh, Shraddha M Hariharan, Graeme L Conn

bioRxiv· November 2024

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Structural and functional diversity of Resistance-Nodulation-Division (RND) efflux pump transporters with implications for antimicrobial resistance.
Logan G Kavanaugh, Debayan Dey, William M Shafer, Graeme L Conn

Microbiol Mol Biol Rev· September 2024

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Ensuring a sustained workforce to combat antibiotic resistance in the 21st century: the critical need for training the next-gen of scientists at the pre-doctoral level.
William M Shafer, Graeme L Conn

Antimicrob Agents Chemother· June 2024

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Differential roles of putative arginine fingers of AAA ATPases Rvb1 and Rvb2.
Jennifer L Warnock, Jacob A Ball, Saman M Najmi, Mina Henes, Amanda Vazquez, Graeme L Conn

bioRxiv· May 2024

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tRNA mG9 modification depends on substrate-specific RNA conformational changes induced by the methyltransferase Trm10.
Sarah E Strassler, Isobel E Bowles, Aiswarya Krishnamohan, Hyejeong Kim, Catherine B Edgington, Graeme L Conn

J Biol Chem· December 2023

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tRNA mG9 modification depends on substrate-specific RNA conformational changes induced by the methyltransferase Trm10.
Sarah E Strassler, Isobel E Bowles, Aiswarya Krishnamohan, Hyejeong Kim, Catherine B Edgington, Graeme L Conn

bioRxiv· October 2023

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Di-berberine conjugates as chemical probes of Pseudomonas aeruginosa MexXY-OprM efflux function and inhibition.
Logan G Kavanaugh, Andrew R Mahoney, Debayan Dey, William M Wuest, Graeme L Conn

NPJ Antimicrob Resist· October 2023

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Di-berberine conjugates as chemical probes of MexXY-OprM efflux function and inhibition.
Logan G Kavanaugh, Andrew R Mahoney, Debayan Dey, William M Wuest, Graeme L Conn

bioRxiv· September 2023

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30S subunit recognition and G1405 modification by the aminoglycoside-resistance 16S ribosomal RNA methyltransferase RmtC.
Pooja Srinivas, Meisam Nosrati, Natalia Zelinskaya, Debayan Dey, Lindsay R Comstock, Graeme L Conn

Proc Natl Acad Sci U S A· June 2023

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30S subunit recognition and G1405 modification by the aminoglycoside-resistance 16S ribosomal RNA methyltransferase RmtC.
Pooja Srinivas, Meisam Nosrati, Natalia Zelinskaya, Debayan Dey, Lindsay R Comstock, Graeme L Conn

bioRxiv· April 2023

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Antisense, but not sense, repeat expanded RNAs activate PKR/eIF2α-dependent ISR in FTD/ALS.
Janani Parameswaran, Nancy Zhang, Elke Braems, Kedamawit Tilahun, Devesh C Pant, Graeme L Conn

Elife· April 2023

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Ribosome-targeting antibiotics and resistance ribosomal RNA methylation.
Learnmore Jeremia, Benjamin E Deprez, Debayan Dey, Graeme L Conn, William M Wuest

RSC Med Chem· April 2023

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Tied up in knots: Untangling substrate recognition by the SPOUT methyltransferases.
Sarah E Strassler, Isobel E Bowles, Debayan Dey, Jane E Jackman, Graeme L Conn

J Biol Chem· October 2022

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Tuberactinomycin antibiotics: Biosynthesis, anti-mycobacterial action, and mechanisms of resistance.
Zane T Laughlin, Graeme L Conn

Front Microbiol· August 2022

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