Publications by authors named "Guokai Chen"

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Long COVID and its Management.
Ho Cheng Koc, Jing Xiao, Weiwei Liu, Yong Li, Guokai Chen

July 2022

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A conserved function of EZH2-PRC2 in repression of primitive endoderm fate in mouse and human pluripotent cells.
Junyu Chen, Boyan Huang, Xuzhao Zhai, Zhe Xu, Shu Sun, Guokai Chen

Stem Cell Reports· November 2025

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Remodeling Cell Adhesion Releases Cardiac Potential of Human Pluripotent Stem Cells with Continuous Proliferation and Accelerated Maturation.
Weiwei Liu, Chuyu Liu, Qian Wang, Chengwu Li, Jiaxian Wang, Guokai Chen

Int J Biol Sci· November 2025

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Modeling mammalian hibernation to improve organ cold preservation: Using the intestine as an example.
Weiya He, Ziqing He, Wenjun Deng, Chuman Wu, Wenjie Huang, Yifu Chen, Guokai Chen

Cell Res· September 2025

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Editorial: Studying rare diseases using induced pluripotent stem cell (iPSC)-based model systems.
Kevin R Francis, Guokai Chen, Erkan Kiris

Front Cell Dev Biol· September 2025

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The modulation of calcium and chloride channels induces cardiomyocytes from human pluripotent stem cells.
Ya Meng, Chunhao Deng, Xia Xiao, Shengnan Wei, Chengcheng Song, Guokai Chen

Int J Biol Sci· January 2025

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Carbon Dots Crosslinked Egg White Hydrogel for Tissue Engineering.
Jun Wu, Josh Haipeng Lei, Moxin Li, Aiping Zhang, Yuan Li, Guokai Chen

Adv Sci (Weinh)· November 2024

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ERK5 promotes autocrine expression to sustain mitogenic balance for cell fate specification in human pluripotent stem cells.
Chengcheng Song, Zhaoying Zhang, Dongliang Leng, Ziqing He, Xuepeng Wang, Guokai Chen

Stem Cell Reports· September 2024

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Medium acidosis drives cardiac differentiation during mesendoderm cell fate specification from human pluripotent stem cells.
Weiwei Liu, Hsun-Ting Hsieh, Ziqing He, Xia Xiao, Chengcheng Song, Guokai Chen

Stem Cell Reports· September 2024

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Integrating spatial and single-cell transcriptomics reveals tumor heterogeneity and intercellular networks in colorectal cancer.
Jing Xiao, Xinyang Yu, Fanlin Meng, Yuncong Zhang, Wenbin Zhou, Guokai Chen

Cell Death Dis· May 2024

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Conserved mechanisms of self-renewal and pluripotency in mouse and human ESCs regulated by simulated microgravity using a 3D clinostat.
Ying Ye, Wenyan Xie, Zhaoru Ma, Xuepeng Wang, Yi Wen, Guokai Chen, Xi Chen

Cell Death Discov· February 2024

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POZ/BTB and AT hook containing zinc finger 1 (PATZ1) suppresses differentiation and regulates metabolism in human embryonic stem cells.
Min Huang, Xiaohua Liao, Xuepeng Wang, Yiwei Qian, Wensheng Zhang, Guokai Chen

Int J Biol Sci· February 2024

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BRD9-mediated control of the TGF-β/Activin/Nodal pathway regulates self-renewal and differentiation of human embryonic stem cells and progression of cancer cells.
Xuepeng Wang, Chengcheng Song, Ying Ye, Yashi Gu, Xuemei Li, Peixin Chen, Di Chen, Xi Chen, Guokai Chen

Nucleic Acids Res· November 2023

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Comprehensive Analysis of Tumor Microenvironment Reveals Prognostic ceRNA Network Related to Immune Infiltration in Sarcoma.
Dongliang Leng, Ziyi Yang, Heng Sun, Chengcheng Song, Chen Huang, Guokai Chen

Clin Cancer Res· October 2023

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Protein Kinase C Modulation Determines the Mesoderm/Extraembryonic Fate Under BMP4 Induction From Human Pluripotent Stem Cells.
Carlos Godoy-Parejo, Chunhao Deng, Jiaqi Xu, Zhaoying Zhang, Zhili Ren, Guokai Chen

Stem Cells· June 2023

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Review immune response of targeting CD39 in cancer.
Yao Liu, Zhongliang Li, Xiaoguang Zhao, Jing Xiao, Jiacheng Bi, Guokai Chen

Biomark Res· June 2023

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Definitive Endodermal Cells Supply an in vitro Source of Mesenchymal Stem/Stromal Cells.
Yumeng Zhang, Ye Yi, Xia Xiao, Lingling Hu, Jiaqi Xu, Ho Cheng Koc, Guokai Chen

Commun Biol· May 2023

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Androgen Signaling Contributes to Sex Differences in Cancer by Inhibiting NF-κB Activation in T Cells and Suppressing Antitumor Immunity.
Xiaomin Zhang, Limin Cheng, Chengqi Gao, Jing Chen, Shuangye Liao, Siyu Chen, Likun Chen, Guokai Chen

Cancer Res· March 2023

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Tumor-associated macrophages-educated reparative macrophages promote diabetic wound healing.
Ruoyu Mu, Zhe Zhang, Congwei Han, Yiming Niu, Zhen Xing, Zhencheng Liao, Guokai Chen

EMBO Mol Med· February 2023

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The Gene Confers Resistance against Brown Planthopper in Rice by Reducing the Production of Limonene.
Charng-Pei Li, Dong-Hong Wu, Shou-Horng Huang, Menghsiao Meng, Hsien-Tzung Shih, Liang-Jwu Chen, Guo-Kai Chen

Int J Mol Sci· January 2023

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Insulin Directs Dichotomous Translational Regulation to Control Human Pluripotent Stem Cell Survival, Proliferation and Pluripotency.
Xiaoxiao Zhou, Zhili Ren, Jiaqi Xu, Chunhao Deng, Zhaoying Zhang, Esther Chi Cheng Huang, Guokai Chen

Int J Biol Sci· July 2022

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Thyroid hormone enhances stem cell maintenance and promotes lineage-specific differentiation in human embryonic stem cells.
Chunhao Deng, Zhaoying Zhang, Faxiang Xu, Jiaqi Xu, Zhili Ren, Guokai Chen

Stem Cell Res Ther· March 2022

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Chemical Pretreatment Activated a Plastic State Amenable to Direct Lineage Reprogramming.
Zhenghao Yang, Xiaochan Xu, Chan Gu, Alexander Valentin Nielsen, Guokai Chen

Front Cell Dev Biol· March 2022

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Nicotinamide promotes cardiomyocyte derivation and survival through kinase inhibition in human pluripotent stem cells.
Ya Meng, Chengcheng Song, Zhili Ren, Xiaohong Li, Xiangyu Yang, Guokai Chen

Cell Death Dis· November 2021

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Lysophosphatidic acid shifts metabolic and transcriptional landscapes to induce a distinct cellular state in human pluripotent stem cells.
Faxiang Xu, Chunhao Deng, Zhili Ren, Liangyu Sun, Ya Meng, Guokai Chen

Cell Rep· November 2021

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