Publications by authors named "Helen Mott"

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ACKnowledging the role of the Activated-Cdc42 associated kinase (ACK) in regulating protein stability in cancer.
Samantha Hodder, Millie Fox, Ana Masara Binti Ahmad Mokhtar, Helen R Mott, Darerca Owen

Small GTPases· December 2023

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SHOCing RAF into action.
Helen R Mott, Darerca Owen

Nat Struct Mol Biol· October 2022

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Membrane extraction by calmodulin underpins the disparate signalling of RalA and RalB.
Samuel G Chamberlain, Darerca Owen, Helen R Mott

Bioessays· June 2022

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Assembly of nuclear dimers of PI3K regulatory subunits is regulated by the Cdc42-activated tyrosine kinase ACK.
Natasha S Clayton, Millie Fox, Jose J Vicenté-Garcia, Courtney M Schroeder, Trevor D Littlewood, Helen R Mott

J Biol Chem· June 2022

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Calmodulin extracts the Ras family protein RalA from lipid bilayers by engagement with two membrane-targeting motifs.
Samuel G Chamberlain, Andrea Gohlke, Arooj Shafiq, Iolo J Squires, Darerca Owen, Helen R Mott

Proc Natl Acad Sci U S A· September 2021

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Affinity maturation of the RLIP76 Ral binding domain to inform the design of stapled peptides targeting the Ral GTPases.
Catherine A Hurd, Paul Brear, Jefferson Revell, Sarah Ross, Helen R Mott

J Biol Chem· August 2021

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Progress in the therapeutic inhibition of Cdc42 signalling.
Natasha P Murphy, Helen R Mott, Darerca Owen

Biochem Soc Trans· June 2021

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Molecular subversion of Cdc42 signalling in cancer.
Natasha P Murphy, Ana Masara Binti Ahmad Mokhtar, Helen R Mott, Darerca Owen

Biochem Soc Trans· June 2021

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A Complete Survey of RhoGDI Targets Reveals Novel Interactions with Atypical Small GTPases.
Ana Masara Binti Ahmad Mokhtar, Samrein B M Ahmed, Nicola J Darling, Matthew Harris, Helen R Mott

Biochemistry· May 2021

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RLIP76: A Structural and Functional Triumvirate.
Jasmine Cornish, Darerca Owen, Helen R Mott

Cancers (Basel)· May 2021

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The structure and function of protein kinase C-related kinases (PRKs).
Georgios Sophocleous, Darerca Owen, Helen R Mott

Biochem Soc Trans· February 2021

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Intrinsically disordered proteins and membranes: a marriage of convenience for cell signalling?
Jasmine Cornish, Samuel G Chamberlain, Darerca Owen, Helen R Mott

Biochem Soc Trans· December 2020

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H, N and C resonance assignments of the HR1c domain of PRK1, a protein kinase C-related kinase.
Georgios Sophocleous, George Wood, Darerca Owen, Helen R Mott

Biomol NMR Assign· October 2020

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Activation of STAT transcription factors by the Rho-family GTPases.
Jessica Corry, Helen R Mott, Darerca Owen

Biochem Soc Trans· October 2020

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Class IA PI3K regulatory subunits: p110-independent roles and structures.
Millie Fox, Helen R Mott, Darerca Owen

Biochem Soc Trans· August 2020

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NMR resonance assignments for the active and inactive conformations of the small G protein RalA.
Arooj Shafiq, Louise J Campbell, Darerca Owen, Helen R Mott

Biomol NMR Assign· April 2020

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The discovery and maturation of peptide biologics targeting the small G-protein Cdc42: A bioblockade for Ras-driven signaling.
George J N Tetley, Natasha P Murphy, Stephane Bonetto, Gabriela Ivanova-Berndt, Jefferson Revell, Helen R Mott

J Biol Chem· February 2020

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Bioblockades join the assault on small G protein signalling.
Helen R Mott, Darerca Owen

Semin Cancer Biol· February 2019

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CRIB effector disorder: exquisite function from chaos.
Darerca Owen, Helen R Mott

Biochem Soc Trans· October 2018

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Allostery and dynamics in small G proteins.
Helen R Mott, Darerca Owen

Biochem Soc Trans· October 2018

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Bond swapping from a charge cloud allows flexible coordination of upstream signals through WASP: Multiple regulatory roles for the WASP basic region.
George J N Tetley, Aydan Szeto, Adam J Fountain, Helen R Mott, Darerca Owen

J Biol Chem· September 2018

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Evaluation of the Intervention Initiative: A Bystander Intervention Program to Prevent Violence Against Women in Universities.
Rachel A Fenton, Helen L Mott

Violence Vict· August 2018

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Structural basis for the shielding function of the dynamic trypanosome variant surface glycoprotein coat.
Thomas Bartossek, Nicola G Jones, Christin Schäfer, Mislav Cvitković, Marius Glogger, Helen R Mott

Nat Microbiol· November 2017

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Genomic Subtypes of Non-invasive Bladder Cancer with Distinct Metabolic Profile and Female Gender Bias in KDM6A Mutation Frequency.
Carolyn D Hurst, Olivia Alder, Fiona M Platt, Alastair Droop, Lucy F Stead, Helen R Mott

Cancer Cell· November 2017

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A dock and coalesce mechanism driven by hydrophobic interactions governs Cdc42 binding with its effector protein ACK.
George J N Tetley, Helen R Mott, R Neil Cooley, Darerca Owen

J Biol Chem· July 2017

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