Publications by authors named "Helena Smartt"

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Propofol-supplemented cardioplegia: A multicenter blinded 3-group randomized trial (Propofol for Myocardial Protection Trial 2: ProMPT2).
Gianni D Angelini, Helena J M Smartt, Katherine Joyce, Rachael Heys, Rachel Maishman

J Thorac Cardiovasc Surg· October 2025

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Cohort profile: Outcome Monitoring After Cardiac Surgery (OMACS) - a prospective UK cohort study of cardiac surgery patients at the Bristol Heart Institute.
Katherine Joyce, Rachel Maishman, Terrie Walker-Smith, Helena Smartt, Emma Hopkins

BMJ Open· February 2025

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Efficacy of propofol-supplemented cardioplegia on biomarkers of organ injury in patients having cardiac surgery using cardiopulmonary bypass: A protocol for a randomised controlled study (ProMPT2).
Rachael Heys, Gianni D Angelini, Katherine Joyce, Helena Smartt, Lucy Culliford

Perfusion· May 2024

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PET-CT-guided CT-guided biopsy in suspected malignant pleural thickening: a randomised trial.
Duneesha de Fonseka, David T Arnold, Helena J M Smartt, Lucy Culliford, Louise Stadon

Eur Respir J· February 2024

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Efficacy of propofol-supplemented cardioplegia on biomarkers of organ injury in patients having cardiac surgery using cardiopulmonary bypass: a statistical analysis plan for the ProMPT-2 randomised controlled trial.
Helena Smartt, Gianni D Angelini, Ben Gibbison, Chris A Rogers

Trials· February 2024

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Providing multimedia information to children and young people increases recruitment to trials: pre-planned meta-analysis of SWATs.
Peter Knapp, Thirimon Moe-Byrne, Jacqueline Martin-Kerry, Rebecca Sheridan, Jenny Roche, Helena J M Smartt

BMC Med· July 2023

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Warm versus cold blood cardioplegia in paediatric congenital heart surgery: a randomized trial.
Serban Stoica, Helena J M Smartt, Rachael Heys, Karen Sheehan, Terrie Walker-Smith

Eur J Cardiothorac Surg· April 2023

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Outcome Monitoring After Cardiac Surgery (OMACS): a single-centre prospective cohort study of cardiac surgery patients.
Terrie Walker-Smith, Katherine Joyce, Rachel Maishman, Helena Smartt, Emma Hopkins

BMJ Open· December 2022

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Supraglottic airway device versus tracheal intubation in the initial airway management of out-of-hospital cardiac arrest: the AIRWAYS-2 cluster RCT.
Jonathan R Benger, Kim Kirby, Sarah Black, Stephen J Brett, Madeleine Clout, Helena Smartt

Health Technol Assess· April 2022

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Cost-effectiveness of the i-gel supraglottic airway device compared to tracheal intubation during out-of-hospital cardiac arrest: Findings from the AIRWAYS-2 randomised controlled trial.
Elizabeth A Stokes, Michelle J Lazaroo, Madeleine Clout, Stephen J Brett, Sarah Black, Helena Smartt

Resuscitation· October 2021

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Randomized trial of the i-gel supraglottic airway device versus tracheal intubation during out of hospital cardiac arrest (AIRWAYS-2): Patient outcomes at three and six months.
Jonathan R Benger, Michelle J Lazaroo, Madeleine Clout, Sarah Voss, Sarah Black, Helena Smartt

Resuscitation· December 2020

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Effect of a Strategy of a Supraglottic Airway Device vs Tracheal Intubation During Out-of-Hospital Cardiac Arrest on Functional Outcome: The AIRWAYS-2 Randomized Clinical Trial.
Jonathan R Benger, Kim Kirby, Sarah Black, Stephen J Brett, Madeleine Clout, Helena Smartt

JAMA· August 2018

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Autolysosomal β-catenin degradation regulates Wnt-autophagy-p62 crosstalk.
Katy J Petherick, Ann C Williams, Jon D Lane, Paloma Ordóñez-Morán, Joerg Huelsken, Helena J M Smartt

EMBO J· July 2013

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LGR5 promotes survival in human colorectal adenoma cells and is upregulated by PGE2: implications for targeting adenoma stem cells with NSAIDs.
Manal R A Al-Kharusi, Helena J M Smartt, Alexander Greenhough, Tracey J Collard, Elizabeth D Emery

Carcinogenesis· May 2013

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β-catenin represses expression of the tumour suppressor 15-prostaglandin dehydrogenase in the normal intestinal epithelium and colorectal tumour cells.
Helena J M Smartt, Alexander Greenhough, Paloma Ordóñez-Morán, Elena Talero, Catherine A Cherry

Gut· September 2012

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Colon tumour cells increase PGE(2) by regulating COX-2 and 15-PGDH to promote survival during the microenvironmental stress of glucose deprivation.
Heather R Roberts, Helena J M Smartt, Alexander Greenhough, Amy E Moore, Ann C Williams

Carcinogenesis· November 2011

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Apoptotic sensitivity of colon cancer cells to histone deacetylase inhibitors is mediated by an Sp1/Sp3-activated transcriptional program involving immediate-early gene induction.
Andrew J Wilson, Anderly C Chueh, Lars Tögel, Georgia A Corner, Naseem Ahmed, Helena J M Smartt

Cancer Res· January 2010

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The COX-2/PGE2 pathway: key roles in the hallmarks of cancer and adaptation to the tumour microenvironment.
Alexander Greenhough, Helena J M Smartt, Amy E Moore, Heather R Roberts, Ann C Williams

Carcinogenesis· March 2009

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p27kip1 Regulates cdk2 activity in the proliferating zone of the mouse intestinal epithelium: potential role in neoplasia.
Helena J M Smartt, Sandra Guilmeau, Shannon V Nasser, Courtney Nicholas, Laura Bancroft

Gastroenterology· July 2007

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Gene expression profiling of intestinal epithelial cell maturation along the crypt-villus axis.
John M Mariadason, Courtney Nicholas, Kaitlin E L'Italien, Min Zhuang, Helena J M Smartt

Gastroenterology· April 2005

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