Publications by authors named "Howard Young"

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Rhomboid protease GlpG regulates type 1 pili quality control and virulence in pathogenic E. coli.
Jimmy Lu, Elena Arutyunova, Bridgette Hartley, Jonas Wong, Hyunjae Chung, Howard S Young

Nat Commun· December 2025

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Production of human cathepsins using Expi293™ mammalian cell expression system for off-target activity of cysteine protease inhibitor screening.
Zoe Turner, Elena Arutyunova, Duong T Bui, Ling Han, Appan Srinivas Kandadai, Howard S Young

Protein Sci· November 2025

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Matrix metalloproteinase inhibition protects against junctophilin-2 proteolysis during doxorubicin-induced cardiotoxicity.
Wesam Bassiouni, Brandon Y H Chan, Andrej Roczkowsky, Joshua W Kranrod, Zabed Mahmud, Howard S Young

Br J Pharmacol· September 2025

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Cytotoxic CD4⁺ T cells exhibit an immunosuppressive shift in checkpoint immunotherapy resistance in melanoma patients.
Heekyong R Bae, Byeongchan Son, Kyoungho Hwang, Suntae Kim, Howard A Young, Eun-Young Kwon

Cancer Immunol Immunother· September 2025

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Structural Elements of Dwarf Open Reading Frame Required for Activation of the Sarco-Endoplasmic Reticulum Calcium Pump.
M'Lynn E Fisher, Justin R Gregory, Stan T J Aanhane, M Joanne Lemieux, Howard S Young

Biochemistry· September 2025

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The non-cytotoxic small molecule NPB does not inhibit BAD phosphorylation and forms colloidal aggregates.
John Maringa Githaka, Tomás Gutiérrez, Zhuang Zhuang Han, Joseph O Primeau, Heather Muranyi, Howard S Young

Commun Med (Lond)· May 2025

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Transmembrane Parkinson's disease mutation of PINK1 leads to altered mitochondrial anchoring.
Raelynn Brassard, Elena Arutyunova, Emmanuella Takyi, L Michel Espinoza-Fonseca, Howard S Young

J Biol Chem· March 2025

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Structural investigation of an RNA device that regulates PD-1 expression in mammalian cells.
Jason R Stagno, Justin C Deme, Vibha Dwivedi, Yun-Tzai Lee, Hyun Kyung Lee, Howard A Young

Nucleic Acids Res· February 2025

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Interleukin-2-mediated NF-κB-dependent mRNA splicing modulates interferon gamma protein production.
Rachel D Van Gelder, Nandan S Gokhale, Emmanuelle Genoyer, Dylan S Omelia, Stephen K Anderson, Howard A Young

EMBO Rep· January 2025

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The contextual interview: a cross-cutting patient-interviewing approach for social context.
Amber Cahill, Matthew Martin, Bridget Beachy, David Bauman, Jordan Howard-Young

Med Educ Online· December 2024

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Chronic Low-Level IFN-γ Expression Disrupts Mitochondrial Complex I Activity in Renal Macrophages: An Early Mechanistic Driver of Lupus Nephritis Pathogenesis.
Heekyong R Bae, Su-Kyung Shin, Ji-Yoon Lee, Yeo Jin Ko, Suntae Kim, Howard A Young, Eun-Young Kwon

Int J Mol Sci· December 2024

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Dietary therapy of murine primary biliary cholangitis induces hepatocellular steatosis: A cautionary tale.
Weici Zhang, Taha Al Tekreeti, Patrick S C Leung, Koichi Tsuneyama, Harleen Dhillon, Howard A Young

Liver Int· October 2024

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Probing the formation of a hetero-dimeric membrane transport complex with dual and mutagenesis.
Nishadh Rathod, M Joanne Lemieux, Christophe Chipot, Benoît Roux, Howard S Young

Chem Sci· August 2024

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A Structural Comparison of Oral SARS-CoV-2 Drug Candidate Ibuzatrelvir Complexed with the Main Protease (M) of SARS-CoV-2 and MERS-CoV.
Pu Chen, Tayla J Van Oers, Elena Arutyunova, Conrad Fischer, Chaoxiang Wang, Howard S Young

JACS Au· August 2024

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Systemic inflammatory Th1 cytokines during Trypanosoma cruzi infection disrupt the typical anatomical cell distribution and phenotypic/functional characteristics of various cell subsets within the thymus.
Maria Estefania Viano, Natalia Soledad Baez, Constanza Savid-Frontera, Ruth Eliana Baigorri, Brenda Dinatale, Howard A Young

Microbes Infect· July 2024

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Aberrant CD8T cells drive reproductive dysfunction in female mice with elevated IFN-γ levels.
Enitome E Bafor, Rebecca A Erwin-Cohen, Toni Martin, Clayton Baker, Adrienne E Kimmel, Howard A Young

Front Immunol· May 2024

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Missense variants in phospholamban and cardiac myosin binding protein identified in patients with a family history and clinical diagnosis of dilated cardiomyopathy.
Gareth P Armanious, M Joanne Lemieux, L Michel Espinoza-Fonseca, Howard S Young

Biochim Biophys Acta Mol Cell Res· April 2024

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Replacement of Lys27 by asparagine in the SERCA regulator myoregulin: A Ca affinity modulator or a catalytic activity switch?
Nishadh Rathod, Guadalupe Guerrero-Serna, Howard S Young, L Michel Espinoza-Fonseca

Biochim Biophys Acta Mol Cell Res· January 2024

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Isolation of single cells from individual mouse ovaries for flow cytometry and functional analysis.
Enitome E Bafor, Toni Martin, Jeffrey Carrell, Megan Karwan, Adrienne E Kimmel, Howard A Young

STAR Protoc· December 2023

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The Effect of Deuteration and Homologation of the Lactam Ring of Nirmatrelvir on Its Biochemical Properties and Oxidative Metabolism.
Elena Arutyunova, Alexandr Belovodskiy, Pu Chen, Muhammad Bashir Khan, Michael Joyce, Howard S Young

ACS Bio Med Chem Au· December 2023

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IL-15 Priming Alters IFN-γ Regulation in Murine NK Cells.
Maria Cimpean, Molly P Keppel, Anastasiia Gainullina, Changxu Fan, Hyogon Sohn, Howard A Young

J Immunol· November 2023

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Chronic inflammation in high-fat diet-fed mice: Unveiling the early pathogenic connection between liver and adipose tissue.
Heekyong R Bae, Su-Kyung Shin, Ji-Hyeon Yoo, Suntae Kim, Howard A Young, Eun-Young Kwon

J Autoimmun· September 2023

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D-Allulose Ameliorates Dysregulated Macrophage Function and Mitochondrial NADH Homeostasis, Mitigating Obesity-Induced Insulin Resistance.
Heekyong R Bae, Su-Kyung Shin, Youngji Han, Ji-Hyeon Yoo, Suntae Kim, Howard A Young, Eun-Young Kwon

Nutrients· September 2023

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IFN-γ and androgens disrupt mitochondrial function in murine myocytes.
John M Fenimore, Danielle A Springer, Maria E Romero, Elijah F Edmondson, Dan W McVicar, Howard A Young

J Pathol· July 2023

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The adaptor protein TRAF3 is an immune checkpoint that inhibits myeloid-derived suppressor cell expansion.
Sining Zhu, Almin I Lalani, Juan Jin, Derek Sant'Angelo, Lori R Covey, Howard A Young

Front Immunol· May 2023

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