Publications by authors named "Hsing Lin Lai"

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Equilibrative nucleoside transporter 2 modulates inosine catabolism to influence astrocyte metabolism and reactivity.
Ya-Gin Chang, Hsin-Chuan Lin, Ching-Pang Chang, Hsing-Lin Lai, Hui-Mei Chen

Cell Rep· October 2025

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Galectin-3 aggravates microglial activation and tau transmission in tauopathy.
Jian Jing Siew, Hui-Mei Chen, Feng-Lan Chiu, Chia-Wei Lee, Yao-Ming Chang, Hsing-Lin Lai

J Clin Invest· January 2024

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A PIAS1 Protective Variant S510G Delays polyQ Disease Onset by Modifying Protein Homeostasis.
Yan Hua Lee, Yu-Shuen Tsai, Che-Chang Chang, Chun-Chen Ho, Hsiu-Ming Shih, Hsing-Lin Lai

Mov Disord· April 2022

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Functional roles of ST8SIA3-mediated sialylation of striatal dopamine D and adenosine A receptors.
Chien-Yu Lin, Hsing-Lin Lai, Hui-Mei Chen, Jian-Jing Siew, Cheng-Te Hsiao

Transl Psychiatry· August 2019

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GSK3β negatively regulates TRAX, a scaffold protein implicated in mental disorders, for NHEJ-mediated DNA repair in neurons.
Ting Chien, Yu-Ting Weng, Shu-Yung Chang, Hsing-Lin Lai, Feng-Lan Chiu

Mol Psychiatry· December 2018

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Adenosine Augmentation Evoked by an ENT1 Inhibitor Improves Memory Impairment and Neuronal Plasticity in the APP/PS1 Mouse Model of Alzheimer's Disease.
Chia-Chia Lee, Ching-Pang Chang, Chun-Jung Lin, Hsing-Lin Lai, Yu-Han Kao

Mol Neurobiol· December 2018

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The D2 Dopamine Receptor Interferes With the Protective Effect of the A Adenosine Receptor on TDP-43 Mislocalization in Experimental Models of Motor Neuron Degeneration.
Chia-You Lai, Yu-Ju Liu, Hsing-Lin Lai, Hui-Mei Chen, Hung-Chi Kuo

Front Neurosci· March 2018

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The type VI adenylyl cyclase protects cardiomyocytes from β-adrenergic stress by a PKA/STAT3-dependent pathway.
Yu-Shuo Wu, Chien-Chang Chen, Chen-Li Chien, Hsing-Lin Lai, Si-Tse Jiang, Lin-Ping Lai

J Biomed Sci· September 2017

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Targeting ENT1 and adenosine tone for the treatment of Huntington's disease.
Yu-Han Kao, Meng-Syuan Lin, Chiung-Mei Chen, Yih-Ru Wu, Hui-Mei Chen, Hsing-Lin Lai

Hum Mol Genet· February 2017

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Type VI adenylyl cyclase negatively regulates GluN2B-mediated LTD and spatial reversal learning.
Ching-Pang Chang, Cheng-Ta Lee, Wen-Hsien Hou, Meng-Syuan Lin, Hsing-Lin Lai

Sci Rep· March 2016

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Activation of AMP-activated protein kinase α1 mediates mislocalization of TDP-43 in amyotrophic lateral sclerosis.
Yu-Ju Liu, Tz-Chuen Ju, Hui-Mei Chen, Yu-Sung Jang, Li-Ming Lee, Hsing-Lin Lai

Hum Mol Genet· February 2015

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Aberrant activation of AMP-activated protein kinase contributes to the abnormal distribution of HuR in amyotrophic lateral sclerosis.
Yu-Ju Liu, Li-Ming Lee, Hsing-Lin Lai, Yijuang Chern

FEBS Lett· February 2015

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A novel Gαs-binding protein, Gas-2 like 2, facilitates the signaling of the A2A adenosine receptor.
Yi-Chih Wu, Hsing-Lin Lai, Wei-Cheng Chang, Jiun-Tsai Lin, Yu-Ju Liu

Biochim Biophys Acta· December 2013

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Lack of type VI adenylyl cyclase (AC6) leads to abnormal sympathetic tone in neonatal mice.
Chen-Li Chien, Meng-Syuan Lin, Hsing-Lin Lai, Yu-Shuo Wu, Ching-Pang Chang

Exp Neurol· October 2013

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Regulation of feedback between protein kinase A and the proteasome system worsens Huntington's disease.
Jiun-Tsai Lin, Wei-Cheng Chang, Hui-Mei Chen, Hsing-Lin Lai, Chih-Yeh Chen

Mol Cell Biol· March 2013

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Type VI adenylyl cyclase regulates neurite extension by binding to Snapin and Snap25.
Chia-Shan Wu, Jiun-Tsai Lin, Chen-Li Chien, Wei-Cheng Chang, Hsing-Lin Lai

Mol Cell Biol· December 2011

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A new drug design targeting the adenosinergic system for Huntington's disease.
Nai-Kuei Huang, Jung-Hsin Lin, Jiun-Tsai Lin, Chia-I Lin, Eric Minwei Liu, Hsing-Lin Lai

PLoS One· November 2011

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Impaired water reabsorption in mice deficient in the type VI adenylyl cyclase (AC6).
Chen-Li Chien, Yu-Shuo Wu, Hsing-Lin Lai, Yen-Hui Chen, Si-Tse Jiang

FEBS Lett· July 2010

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The A2A adenosine receptor rescues the urea cycle deficiency of Huntington's disease by enhancing the activity of the ubiquitin-proteasome system.
Ming-Chang Chiang, Hui-Mei Chen, Hsing-Lin Lai, Hsiao-Wen Chen, Szu-Yi Chou

Hum Mol Genet· August 2009

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Expanded-polyglutamine huntingtin protein suppresses the secretion and production of a chemokine (CCL5/RANTES) by astrocytes.
Szu-Yi Chou, Ju-Yun Weng, Hsing-Lin Lai, Fang Liao, Synthia H Sun

J Neurosci· March 2008

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Regulation of type V adenylate cyclase by Ric8a, a guanine nucleotide exchange factor.
Shyi-Chyi Wang, Hsing-Lin Lai, Yi-Ting Chiu, Ren Ou, Chuen-Lin Huang

Biochem J· September 2007

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Rescue of p53 blockage by the A(2A) adenosine receptor via a novel interacting protein, translin-associated protein X.
Chung-Nan Sun, Hsiao-Chun Cheng, Jui-Ling Chou, Shen-Yang Lee, Ya-Wen Lin, Hsing-Lin Lai

Mol Pharmacol· August 2006

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CGS21680 attenuates symptoms of Huntington's disease in a transgenic mouse model.
Szu-Yi Chou, Yi-Chao Lee, Hui-Mei Chen, Ming-Chang Chiang, Hsing-Lin Lai

J Neurochem· April 2005

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Regulation of type VI adenylyl cyclase by Snapin, a SNAP25-binding protein.
Jui-Ling Chou, Chuen-Lin Huang, Hsing-Lin Lai, Amos C Hung, Chen-Li Chien

J Biol Chem· October 2004

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An important functional role of the N terminus domain of type VI adenylyl cyclase in Galphai-mediated inhibition.
Yu-Ya Kao, Hsing-Lin Lai, Ming-Jing Hwang, Yijuang Chern

J Biol Chem· August 2004

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