Publications by authors named "Hyuk Ko"

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Progressive tooth pattern changes in Cilk1-deficient mice depending on Hedgehog signaling.
Minjae Kyeong, Ju-Kyung Jeong, Dinuka Adasooriya, Shiqi Kan, Jiwoo Kim, Hyuk Wan Ko

Int J Oral Sci· December 2025

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Cilk1 Is Essential for Mesenchymal Cilia Maintenance and Epithelial-mesenchymal Crosstalk in Intestinal Villus Morphogenesis.
Jieun Song, Suyeon Je, Bawool Lee, Hyuk Wan Ko

Cell Mol Gastroenterol Hepatol· November 2025

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The PNPLA3 I148M variant is associated with immune cell infiltration and advanced fibrosis in MASLD: a prospective genotype-phenotype study.
Jaejun Lee, Jung Hoon Cha, Hee Sun Cho, Keungmo Yang, Hyun Yang, Hyuk Wan Ko

J Gastroenterol· October 2025

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Opposing regulation of the K63-linked polyubiquitination of RIPK3 by SMURF1 and USP5 in necroptosis.
Chi Hyun Hwang, Minhong Lee, Ju Won Kim, Young Woo Nam, Gyuho Hwang, Hyuk Wan Ko

Nat Commun· August 2025

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SHANK2 establishes auditory hair bundle architecture essential for mammalian hearing.
Han Seul Choi, Hyeyoung Park, Hyehyun Min, Kwan Soo Kim, Soo Min Kim, Hyuk Wan Ko

Proc Natl Acad Sci U S A· July 2025

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Ebastine-mediated destabilization of E3 ligase MKRN1 protects against metabolic dysfunction-associated steatohepatitis.
Seungyeon Kim, Hyun-Ji Han, Hyunjin Rho, Subin Kang, Sulagna Mukherjee, Hyuk Wan Ko

Cell Mol Life Sci· January 2025

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Distinct roles of centriole distal appendage proteins in ciliary assembly and disassembly.
Su-Yeon Je, Hyuk Wan Ko

Cell Commun Signal· December 2024

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A novel indole derivative, 2-{3-[1-(benzylsulfonyl)piperidin-4-yl]-2-methyl-1H-indol-1-yl}-1-(pyrrolidin-1-yl)ethenone, suppresses hedgehog signaling and drug-resistant tumor growth.
Joo Hyun Jung, Hwayoung Lee, Jiyeon Jeon, Yoon Ji Lee, Hossam Nada, Hyuk Wan Ko

Arch Pharm (Weinheim)· October 2024

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TMEM132A regulates Wnt/β-catenin signaling through stabilizing LRP6 during mouse embryonic development.
Shin Ae Oh, Jiyeon Jeon, Su-Yeon Je, Seoyoung Kim, Joohyun Jung, Hyuk Wan Ko

Cell Commun Signal· October 2024

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Propagation effects in polarization-gated attosecond soft-X-ray pulse generation.
Sambit Mitra, Johannes Schötz, Chunmei Zhang, Dong Hyuk Ko, Zenghu Chang

Opt Express· January 2024

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Fabrication of liraglutide-encapsulated triple layer hyaluronic acid microneedles (TLMs) for the treatment of obesity.
Seorin Juhng, Jieun Song, Jeongyun You, Jihyun Park, Huisuk Yang, Hyuk Wan Ko

Lab Chip· May 2023

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Egg Microneedle for Transdermal Delivery of Active Liraglutide.
Jeongyun You, Seorin Juhng, Jieun Song, Jihyun Park, Mingyu Jang, Hyuk Wan Ko

Adv Healthc Mater· April 2023

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Tissue-specific requirement of sodium channel and clathrin linker 1 (Sclt1) for ciliogenesis during limb development.
Hankyu Lee, Kyeong-Hye Moon, Jieun Song, Suyeon Je, Jinwoong Bok, Hyuk Wan Ko

Front Cell Dev Biol· November 2022

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KLC3 Regulates Ciliary Trafficking and Cyst Progression in CILK1 Deficiency-Related Polycystic Kidney Disease.
Gyuyeong Rah, Hwayeon Cha, Joohee Kim, Jieun Song, Hyunho Kim, Hyuk Wan Ko, Je Yeong Ko

J Am Soc Nephrol· September 2022

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Upregulated Guanine Deaminase Is Involved in Hyperpigmentation of Seborrheic Keratosis via Uric Acid Release.
Kyung Ah Cheong, In Sup Kil, Hyuk Wan Ko, Ai-Young Lee

Int J Mol Sci· November 2021

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Dysregulation of sonic hedgehog signaling causes hearing loss in ciliopathy mouse models.
Kyeong-Hye Moon, Ji-Hyun Ma, Hyehyun Min, Heiyeun Koo, HongKyung Kim, Hyuk Wan Ko

Elife· December 2020

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Autophagy induction promotes renal cyst growth in polycystic kidney disease.
Eun Ji Lee, Je Yeong Ko, Sumin Oh, Jaehee Jun, Hyowon Mun, Hyuk Wan Ko

EBioMedicine· October 2020

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Cell cycle-related kinase is a crucial regulator for ciliogenesis and Hedgehog signaling in embryonic mouse lung development.
Hankyu Lee, Hyuk Wan Ko

BMB Rep· July 2020

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Combination of PD-L1 and PVR determines sensitivity to PD-1 blockade.
Bo Ryeong Lee, Sehyun Chae, Jihyun Moon, Myeong Joon Kim, Hankyu Lee, Hyuk Wan Ko

JCI Insight· July 2020

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Activation of sonic hedgehog signaling by a Smoothened agonist restores congenital defects in mouse models of endocrine-cerebro-osteodysplasia syndrome.
Jeong-Oh Shin, Jieun Song, Han Seul Choi, Jisu Lee, Kyeong Lee, Hyuk Wan Ko

EBioMedicine· November 2019

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Fibroblast growth factor receptor influences primary cilium length through an interaction with intestinal cell kinase.
Michaela Kunova Bosakova, Alexandru Nita, Tomas Gregor, Miroslav Varecha, Iva Gudernova, Peter Konik, Hyuk Wan Ko, Deborah Krakow

Proc Natl Acad Sci U S A· March 2019

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Multilayer fabrication of unobtrusive poly(dimethylsiloxane) nanobrush for tunable cell adhesion.
Soo Sang Chae, Joo Hyun Jung, Won Jin Choi, Joung Kyu Park, Hong Koo Baik, Hyuk Wan Ko

Sci Rep· February 2019

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Repeated restraint stress promotes hippocampal neuronal cell ciliogenesis and proliferation in mice.
Kyounghye Lee, Hyuk Wan Ko

Lab Anim Res· December 2018

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Sauchinone controls hepatic cholesterol homeostasis by the negative regulation of PCSK9 transcriptional network.
Hee-Sung Chae, Byoung Hoon You, Dong-Yeop Kim, Hankyu Lee, Hyuk Wan Ko, Hyun-Jeong Ko

Sci Rep· April 2018

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PEGylated hyaluronic acid-coated liposome for enhanced in vivo efficacy of sorafenib via active tumor cell targeting and prolonged systemic exposure.
Lingxuan Mo, Jae Geun Song, Hankyu Lee, Mengjia Zhao, Hyeon Young Kim, Hyuk Wan Ko

Nanomedicine· February 2018

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