Publications by authors named "ID Goldman"

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Mechanistic insights into mutation in the proton-coupled folate transporter (SLC46A1) causing hereditary folate malabsorption.
Prithviraj Nandigrami, I David Goldman, Andras Fiser

J Biol Chem· March 2025

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Structural basis of antifolate recognition and transport by PCFT.
Joanne L Parker, Justin C Deme, Gabriel Kuteyi, Zhiyi Wu, Jiandong Huo, I David Goldman

Nature· July 2021

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A proton-coupled folate transporter mutation causing hereditary folate malabsorption locks the protein in an inward-open conformation.
He-Qin Zhan, Mitra Najmi, Kai Lin, Srinivas Aluri, Andras Fiser, I David Goldman

J Biol Chem· November 2020

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Upregulation of reduced folate carrier by vitamin D enhances brain folate uptake in mice lacking folate receptor alpha.
Camille Alam, Susanne Aufreiter, Constantine J Georgiou, Md Tozammel Hoque, Richard H Finnell, I David Goldman

Proc Natl Acad Sci U S A· August 2019

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Substitutions that lock and unlock the proton-coupled folate transporter (PCFT-SLC46A1) in an inward-open conformation.
Srinivas Aluri, Rongbao Zhao, Kai Lin, Daniel Sanghoon Shin, Andras Fiser, I David Goldman

J Biol Chem· May 2019

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Substituted-cysteine accessibility and cross-linking identify an exofacial cleft in the 7th and 8th helices of the proton-coupled folate transporter (SLC46A1).
Srinivas Aluri, Rongbao Zhao, Andras Fiser, I David Goldman

Am J Physiol Cell Physiol· March 2018

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Concentrative Transport of Antifolates Mediated by the Proton-Coupled Folate Transporter (SLC46A1); Augmentation by a HEPES Buffer.
Rongbao Zhao, Mitra Najmi, Srinivas Aluri, David C Spray, I David Goldman

Mol Pharmacol· March 2018

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Hereditary folate malabsorption due to a mutation in the external gate of the proton-coupled folate transporter SLC46A1.
Srinivas Aluri, Rongbao Zhao, Charlotte Lubout, Susanna M I Goorden, Andras Fiser, I David Goldman

Blood Adv· January 2018

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Residues in the eighth transmembrane domain of the proton-coupled folate transporter (SLC46A1) play an important role in defining the aqueous translocation pathway and in folate substrate binding.
Srinivas Aluri, Rongbao Zhao, Andras Fiser, I David Goldman

Biochim Biophys Acta Biomembr· November 2017

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Regulation of Reduced Folate Carrier (RFC) by Vitamin D Receptor at the Blood-Brain Barrier.
Camille Alam, Md Tozammel Hoque, Richard H Finnell, I David Goldman, Reina Bendayan

Mol Pharm· November 2017

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Impact of posttranslational modifications of engineered cysteines on the substituted cysteine accessibility method: evidence for glutathionylation.
Rongbao Zhao, Mitra Najmi, Srinivas Aluri, I David Goldman

Am J Physiol Cell Physiol· April 2017

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The proton-coupled folate transporter (PCFT-SLC46A1) and the syndrome of systemic and cerebral folate deficiency of infancy: Hereditary folate malabsorption.
Rongbao Zhao, Srinivas Aluri, I David Goldman

Mol Aspects Med· February 2017

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Role of the tryptophan residues in proton-coupled folate transporter (PCFT-SLC46A1) function.
Mitra Najmi, Rongbao Zhao, Andras Fiser, I David Goldman

Am J Physiol Cell Physiol· July 2016

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Identification of an Extracellular Gate for the Proton-coupled Folate Transporter (PCFT-SLC46A1) by Cysteine Cross-linking.
Rongbao Zhao, Mitra Najmi, Andras Fiser, I David Goldman

J Biol Chem· April 2016

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A conversation with Susan Band Horwitz.
Susan Band Horwitz, I David Goldman

Annu Rev Pharmacol Toxicol· September 2015

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Determinants of the activities of antifolates delivered into cells by folate-receptor-mediated endocytosis.
Rongbao Zhao, Michele Visentin, I David Goldman

Cancer Chemother Pharmacol· June 2015

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Identification of Tyr residues that enhance folate substrate binding and constrain oscillation of the proton-coupled folate transporter (PCFT-SLC46A1).
Michele Visentin, Ersin Selcuk Unal, Mitra Najmi, Andras Fiser, Rongbao Zhao, I David Goldman

Am J Physiol Cell Physiol· April 2015

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The intestinal absorption of folates.
Michele Visentin, Ndeye Diop-Bove, Rongbao Zhao, I David Goldman

Annu Rev Physiol· September 2014

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The impact of 5-formyltetrahydrofolate on the anti-tumor activity of pralatrexate, as compared to methotrexate, in HeLa cells in vitro.
Michele Visentin, Ersin Selcuk Unal, I David Goldman

Cancer Chemother Pharmacol· May 2014

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Enhanced receptor-mediated endocytosis and cytotoxicity of a folic acid-desacetylvinblastine monohydrazide conjugate in a pemetrexed-resistant cell line lacking folate-specific facilitative carriers but with increased folate receptor expression.
Rongbao Zhao, Ndeye Diop-Bove, I David Goldman

Mol Pharmacol· February 2014

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The proton-coupled folate transporter: physiological and pharmacological roles.
Rongbao Zhao, I David Goldman

Curr Opin Pharmacol· December 2013

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The Concise Guide to PHARMACOLOGY 2013/14: overview.
Stephen P H Alexander, Helen E Benson, Elena Faccenda, Adam J Pawson, Joanna L Sharman, I D Goldman

Br J Pharmacol· December 2013

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