Publications by authors named "Iain D Kerr"

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The Science and Art of Clinical Genetic Variant Classification and Its Impact on Test Accuracy.
Hunter H Giles, Madhuri R Hegde, Elaine Lyon, Christine M Stanley, Iain D Kerr, Megan E Garlapow, Julie M Eggington

Annu Rev Genomics Hum Genet· August 2021

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Assessment of in silico protein sequence analysis in the clinical classification of variants in cancer risk genes.
Iain D Kerr, Hannah C Cox, Kelsey Moyes, Brent Evans, Brianna C Burdett

J Community Genet· April 2017

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Comparison of locus-specific databases for BRCA1 and BRCA2 variants reveals disparity in variant classification within and among databases.
Paris J Vail, Brian Morris, Aric van Kan, Brianna C Burdett, Kelsey Moyes, Iain D Kerr

J Community Genet· October 2015

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Structure of the human MLH1 N-terminus: implications for predisposition to Lynch syndrome.
Hong Wu, Hong Zeng, Robert Lam, Wolfram Tempel, Iain D Kerr

Acta Crystallogr F Struct Biol Commun· August 2015

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In vitro and in vivo studies of the trypanocidal properties of WRR-483 against Trypanosoma cruzi.
Yen Ting Chen, Linda S Brinen, Iain D Kerr, Elizabeth Hansell, Patricia S Doyle, James H McKerrow

PLoS Negl Trop Dis· September 2010

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A novel Entamoeba histolytica cysteine proteinase, EhCP4, is key for invasive amebiasis and a therapeutic target.
Chen He, George P Nora, Eric L Schneider, Iain D Kerr, Elizabeth Hansell, James McKerrow

J Biol Chem· June 2010

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Crystal Structures of TbCatB and rhodesain, potential chemotherapeutic targets and major cysteine proteases of Trypanosoma brucei.
Iain D Kerr, Peng Wu, Rachael Marion-Tsukamaki, Zachary B Mackey, Linda S Brinen

PLoS Negl Trop Dis· June 2010

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Nonpeptidic tetrafluorophenoxymethyl ketone cruzain inhibitors as promising new leads for Chagas disease chemotherapy.
Katrien Brak, Iain D Kerr, Kimberly T Barrett, Nobuhiro Fuchi, Moumita Debnath, James H McKerrow

J Med Chem· February 2010

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Structural studies of pterin-based inhibitors of dihydropteroate synthase.
Kirk E Hevener, Mi-Kyung Yun, Jianjun Qi, Iain D Kerr, Kerim Babaoglu

J Med Chem· January 2010

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Novel non-peptidic vinylsulfones targeting the S2 and S3 subsites of parasite cysteine proteases.
Clifford Bryant, Iain D Kerr, Moumita Debnath, Kenny K H Ang, Joseline Ratnam, James H McKerrow

Bioorg Med Chem Lett· November 2009

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Hemoglobin cleavage site-specificity of the Plasmodium falciparum cysteine proteases falcipain-2 and falcipain-3.
Shoba Subramanian, Markus Hardt, Youngchool Choe, Richard K Niles, Eric B Johansen, Iain D Kerr

PLoS One· October 2009

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Vinyl sulfones as antiparasitic agents and a structural basis for drug design.
Iain D Kerr, Ji H Lee, Christopher J Farady, Rachael Marion, Mathias Rickert, James H McKerrow

J Biol Chem· September 2009

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Structures of falcipain-2 and falcipain-3 bound to small molecule inhibitors: implications for substrate specificity.
Iain D Kerr, Ji H Lee, Kailash C Pandey, Amanda Harrison, Mohammed Sajid

J Med Chem· February 2009

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Crystallographic and NMR analyses of UvsW and UvsW.1 from bacteriophage T4.
Iain D Kerr, Sivashankar Sivakolundu, Zhenmei Li, Jeffrey C Buchsbaum, Luke A Knox

J Biol Chem· November 2007

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Insights into ssDNA recognition by the OB fold from a structural and thermodynamic study of Sulfolobus SSB protein.
Iain D Kerr, Ross I M Wadsworth, Liza Cubeddu, Wulf Blankenfeldt, James H Naismith

EMBO J· June 2003

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Variation on a theme of SDR. dTDP-6-deoxy-L- lyxo-4-hexulose reductase (RmlD) shows a new Mg2+-dependent dimerization mode.
Wulf Blankenfeldt, Iain D Kerr, Marie-France Giraud, Helen J McMiken, Gordon Leonard

Structure· June 2002

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