Publications by authors named "Ignacio Leon"

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Advances in copper complexes in cancer treatment.
Lucía M Balsa, Lucía Santa Maria de la Parra, Olivia Espindola-Moreno, Ignacio E León

Drug Discov Today· December 2025

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Structural influences on the oxidation and anticancer activities of dicopper(II) complexes containing different selenium and sulfur ligands.
Daniele C Durigon, Ronny R Ribeiro, Olivia Espindola-Moreno, Ignacio E León, Giordano Poneti

Dalton Trans· December 2025

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Structural, spectroscopic, theoretical, and magnetic investigations of a novel cubane-like tetranuclear copper(II)-hydrazone complex.
Lucía Santa Maria de la Parra, Leonardo E Riafrecha, Gustavo A Echeverría, Luis Lezama, Oscar E Piro

Dalton Trans· September 2025

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An oral delivery approach for riboflavin-targeted platinum(II)-loaded lipid nanoparticles into alginate-gelatin matrices against 2D and 3D colorectal carcinoma models.
Tugce Boztepe, Federico Karp, Silvia Cabrera, José Aleman, Diego G Lamas

J Inorg Biochem· August 2025

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Cannabinoids: Adaptogens or Not?
Federico Karp, Ignacio E León

Cannabis Cannabinoid Res· June 2025

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Antiproliferative activity of a series of copper(II) complexes derived from a furan-containing -acylhydrazone: monomers, dimers, charge status, and cell mechanistic studies on triple negative breast cancer cells.
Olivia Espindola-Moreno, Fagner da Silva Moura, Lucía Santa Maria de la Parra, Carolina Stellet, Jilder D P Serna

Dalton Trans· February 2025

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Deciphering the Effect of a Cu(II)-hydrazone Complex on Intracellular Cell Signalling Pathways in a Human Osteosarcoma 2D and 3D Models.
Lucía M Balsa, Lucía Santa Maria de la Parra, Valeria Ferretti, Ignacio E León

Chembiochem· November 2024

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Transition metal complexes: a new generation of anticancer drugs.
Ignacio E León

Future Med Chem· October 2024

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Metallocompounds as anticancer agents against osteosarcoma.
Lucía Santa Maria de la Parra, Lucía M Balsa, Ignacio E León

Drug Discov Today· September 2024

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Promising Dual Anticancer and Antimetastatic Action by a Cu(II) Complex Derived from Acylhydrazone on Human Osteosarcoma Models.
Lucía Santa Maria de la Parra, Adolfo I B Romo, Joaquín Rodríguez-López, Otaciro R Nascimento, Gustavo A Echeverría

Inorg Chem· March 2024

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New copper(II) and oxidovanadium(IV) complexes with a vitamin B Schiff base: mechanism of action and synergy studies on 2D and 3D human osteosarcoma cell models.
Lucia M Balsa, Valeria Ferretti, Marco Sottile, Patrique Nunes, João Costa Pessoa

Dalton Trans· February 2024

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5-Nitrofuryl-Containing Thiosemicarbazone Gold(I) Compounds: Synthesis, Stability Studies, and Anticancer Activity.
Esteban Rodríguez-Arce, Eric Gavrilov, Ximena Alvite, Nazia Nayeem, Ignacio E León

Chempluschem· December 2023

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5-Nitrofuryl-Containing Thiosemicarbazone Gold(I) Compounds: Synthesis, Stability Studies, and Anticancer Activity.
Esteban Rodríguez-Arce, Eric Gavrilov, Ximena Alvite, Nazia Nayeem, Ignacio E León

Chempluschem· December 2023

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Platinum(IV)-Gold(I) Agents with Promising Anticancer Activity: Selected Studies in 2D and 3D Triple-Negative Breast Cancer Models.
Javier E López-Hernández, Nazia Nayeem, José P Cerón-Carrasco, Afruja Ahad, Aiman Hafeez

Chemistry· October 2023

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Cu(II)-acylhydrazone complex, a potent and selective antitumor agent against human osteosarcoma: Mechanism of action studies over in vitro and in vivo models.
Lucia M Balsa, Luisina M Solernó, Maria R Rodriguez, Beatriz S Parajón-Costa, Ana C Gonzalez-Baró

Chem Biol Interact· October 2023

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Anticancer activity of Ni(II) and Zn(II) complexes based on new unsymmetrical salophen-type ligands: synthesis, characterization and single-crystal X-ray diffraction.
David Villaman, Andrés Vega, Lucía Santa Maria de la Parra, Ignacio E León, Pedro Levín

Dalton Trans· August 2023

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Finding New Molecular Targets of Two Copper(II)-Hydrazone Complexes on Triple-Negative Breast Cancer Cells Using Mass-Spectrometry-Based Quantitative Proteomics.
Lucia M Balsa, María R Rodriguez, Verónica Ferraresi-Curotto, Beatriz S Parajón-Costa, Ana C Gonzalez-Baró

Int J Mol Sci· April 2023

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Exploring pta Alternatives in the Development of Ruthenium-Arene Anticancer Compounds.
Jakob Kljun, Mihaela Rebernik, Lucía M Balsa, Jerneja Kladnik, Uroš Rapuš

Molecules· March 2023

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Design, Synthesis, Characterization, and Evaluation of the Anti-HT-29 Colorectal Cell Line Activity of Novel 8-Oxyquinolinate-Platinum(II)-Loaded Nanostructured Lipid Carriers Targeted with Riboflavin.
Tugce Boztepe, Sebastián Scioli-Montoto, Rocio C Gambaro, María Esperanza Ruiz, Silvia Cabrera

Pharmaceutics· March 2023

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New ternary Fe(III)-8-hydroxyquinoline-reduced Schiff base complexes as selective anticancer drug candidates.
Valeria Ferretti, Cristina P Matos, Catarina Canelas, João Costa Pessoa, Ana Isabel Tomaz

J Inorg Biochem· November 2022

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Active and pH-Sensitive Nanopackaging Based on Polymeric Anthocyanin/Natural or Organo-Modified Montmorillonite Blends: Characterization and Assessment of Cytotoxicity.
Tomy J Gutiérrez, Ignacio E León, Alejandra G Ponce, Vera A Alvarez

Polymers (Basel)· November 2022

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Anticancer and Antioxidant Activity of Water-Soluble Polysaccharides from aff. against Human Osteosarcoma Cells.
Tatiana Muñoz-Castiblanco, Lucía Santa Maria de la Parra, Rocio Peña-Cañón, Juan Camilo Mejía-Giraldo, Ignacio E León

Int J Mol Sci· November 2022

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Novel Phenobarbital-Loaded Nanostructured Lipid Carriers for Epilepsy Treatment: From QbD to Evaluation.
Sebastian Scioli-Montoto, Maria Laura Sbaraglini, Jose Sebastian Cisneros, Cecilia Yamil Chain, Valeria Ferretti

Front Chem· August 2022

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Focal adhesion kinase inhibitors in the treatment of solid tumors: Preclinical and clinical evidence.
Patricia A Quispe, Martin J Lavecchia, Ignacio E León

Drug Discov Today· February 2022

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Antiproliferative activity of two copper (II) complexes on colorectal cancer cell models: Impact on ROS production, apoptosis induction and NF-κB inhibition.
Maria C Ruiz, Karen Perelmulter, Pedro Levín, Adolfo I B Romo, Luis Lemus

Eur J Pharm Sci· February 2022

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