Publications by authors named "Issam Ben Sahra"

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Rate-limiting enzymes in nucleotide metabolism synchronize nucleotide biosynthesis and chromatin formation.
Shashank Srivastava, Daniela Samaniego-Castruita, Shubhi Srivastava, Sakshi Khurana, Jalees Rehman, Issam Ben-Sahra

Mol Cell· December 2025

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The extracellular matrix drives guanylate production and protects pancreatic cancer cells from oxaliplatin-induced DNA damage.
Georgios Efthymiou, Eugénie Lohmann, Claudio Montenegro, Paraskevi Kousteridou, Pierre Bertrand, Issam Ben-Sahra

Sci Adv· December 2025

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Accumulation of succinate suppresses de novo purine synthesis through succinylation-mediated control of the mitochondrial folate cycle.
Mushtaq A Nengroo, Austin T Klein, Heather S Carr, Olivia Vidal-Cruchez, Umakant Sahu, Issam Ben-Sahra

Mol Cell· November 2025

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De Novo Serine Synthesis Is a Metabolic Vulnerability That Can Be Exploited to Overcome Sunitinib Resistance in Advanced Renal Cell Carcinoma.
Manon Teisseire, Umakant Sahu, Julien Parola, Meng-Chen Tsai, Valérie Vial, Issam Ben-Sahra

Cancer Res· May 2025

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Rate Limiting Enzymes in Nucleotide Metabolism Synchronize Nucleotide Biosynthesis and Chromatin Formation.
Shashank Srivastava, Daniela Samaniego-Castruita, Sakshi Khurana, Vipul Shukla, Issam Ben-Sahra

bioRxiv· May 2025

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Control of circadian muscle glucose metabolism through the BMAL1-HIF axis in obesity.
Claire A Chaikin, Abhishek V Thakkar, Adam W T Steffeck, Eric M Pfrender, Kaitlyn Hung, Issam Ben-Sahra

Proc Natl Acad Sci U S A· April 2025

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Parallel multiOMIC analysis reveals glutamine deprivation enhances directed differentiation of renal organoids.
Iman Sarami, Katherine E Hekman, Ashwani Kumar Gupta, Justin M Snider, David Ivancic, Issam Ben-Sahra

bioRxiv· March 2025

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Succinate dehydrogenase activity supports de novo purine synthesis.
Mushtaq A Nengroo, Austin T Klein, Heather S Carr, Olivia Vidal-Cruchez, Umakant Sahu, Issam Ben-Sahra

bioRxiv· March 2025

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Purifying and profiling lysosomes to expand understanding of lysosomal dysfunction-associated diseases.
Ali Shilatifard, Issam Ben-Sahra

J Clin Invest· February 2025

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Mechano-dependent sorbitol accumulation supports biomolecular condensate.
Stephanie Torrino, William M Oldham, Andrés R Tejedor, Ignacio S Burgos, Lara Nasr, Issam Ben-Sahra

Cell· January 2025

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Brain-penetrating molecule might offer a route to treat glioblastoma tumours.
Mushtaq A Nengroo, Issam Ben-Sahra

Nature· December 2024

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ASCT2 is a major contributor to serine uptake in cancer cells.
Kelly O Conger, Christopher Chidley, Mete Emir Ozgurses, Huiping Zhao, Yumi Kim, Issam Ben-Sahra

Cell Rep· August 2024

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Longitudinal trajectories of branched chain amino acids through young adulthood and diabetes in later life.
Konrad T Sawicki, Hongyan Ning, Norrina B Allen, Mercedes R Carnethon, Amisha Wallia, Issam Ben-Sahra

JCI Insight· June 2024

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Pyrimidines maintain mitochondrial pyruvate oxidation to support de novo lipogenesis.
Umakant Sahu, Elodie Villa, Colleen R Reczek, Zibo Zhao, Brendan P O'Hara, Issam Ben-Sahra

Science· March 2024

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Pro-905, a Novel Purine Antimetabolite, Combines with Glutamine Amidotransferase Inhibition to Suppress Growth of Malignant Peripheral Nerve Sheath Tumor.
Kathryn M Lemberg, Eunus S Ali, Marcela Krecmerova, Joanna Marie H Aguilar, Jesse Alt, Issam Ben-Sahra

Mol Cancer Ther· December 2023

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Regulation of nucleotide metabolism in cancers and immune disorders.
Eunus S Ali, Issam Ben-Sahra

Trends Cell Biol· November 2023

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Iron drives anabolic metabolism through active histone demethylation and mTORC1.
Jason S Shapiro, Hsiang-Chun Chang, Yuki Tatekoshi, Zibo Zhao, Zohra Sattar Waxali, Issam Ben-Sahra

Nat Cell Biol· October 2023

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ASCT2 is the primary serine transporter in cancer cells.
Kelly O Conger, Christopher Chidley, Mete Emir Ozgurses, Huiping Zhao, Yumi Kim, Issam Ben-Sahra

bioRxiv· October 2023

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Therapeutic targeting of metabolic vulnerabilities in cancers with MLL3/4-COMPASS epigenetic regulator mutations.
Zibo Zhao, Kaixiang Cao, Jun Watanabe, Cassandra N Philips, Jacob M Zeidner, Issam Ben-Sahra

J Clin Invest· July 2023

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Mechano-dependent sorbitol accumulation supports biomolecular condensate.
Stephanie Torrino, William M Oldham, Andrés R Tejedor, Ignacio S Burgos, Nesrine Rachedi, Issam Ben-Sahra

bioRxiv· July 2023

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Ribonucleotide reductase regulatory subunit M2 drives glioblastoma TMZ resistance through modulation of dNTP production.
Ella N Perrault, Jack M Shireman, Eunus S Ali, Peiyu Lin, Isabelle Preddy, Issam Ben-Sahra

Sci Adv· May 2023

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Purine synthesis suppression reduces the development and progression of pulmonary hypertension in rodent models.
Qian Ma, Qiuhua Yang, Jiean Xu, Hunter G Sellers, Zach L Brown, Issam Ben-Sahra

Eur Heart J· April 2023

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Longitudinal trajectories of branched chain amino acids through young adulthood and diabetes in later life.
Konrad T Sawicki, Hongyan Ning, Norrina B Allen, Mercedes R Carnethon, Amisha Wallia, Issam Ben-Sahra

JCI Insight· April 2023

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The cell cycle loops UTP around CAD.
Umakant Sahu, Issam Ben-Sahra

Nat Metab· February 2023

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GATOR2 rings GATOR1 to speak to mTORC1.
Umakant Sahu, Issam Ben-Sahra

Mol Cell· January 2023

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