Publications by authors named "J Niles"

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Targeting Aurora Kinases as Essential Cell-Cycle Regulators to Deliver Multi-Stage Antimalarials Against Plasmodium Falciparum.
Henrico Langeveld, Keletso Maepa, Marché Maree, Jessica L Thibaud, Nicolaas Salomane, Jacquin C Niles

Angew Chem Int Ed Engl· December 2025

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Shared Binding Site but Divergent Resistance Profiles Uncover Novel Resistance Mechanisms in HSP90 Inhibitors.
Fu-Hsuan Ko, Amanda K Lukens, Mariana Laureano de Souza, Alex Foy, Jason Hsiao, Jacquin Niles

bioRxiv· November 2025

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Optimization of 2,8-Diaryl-1,5-naphthyridines as Phosphatidylinositol 4-Kinase Inhibitors with Improved ADME Profiles and In Vivo Efficacy.
Godwin A Dziwornu, Donald Seanego, Stephen Fienberg, Venkata S Sypu, Nicolaas Salomane, Jacquin C Niles

J Med Chem· October 2025

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Collateral hypersensitivity between ZY19489 and piperaquine neutralizes PfCRT-mediated drug efflux and Plasmodium falciparum resistance.
John Okombo, Tolla Ndiaye, Tarrick Qahash, Igor M R Moura, Eva Gil-Iturbe, Jacquin C Niles

Res Sq· October 2025

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The Human Chk1 Inhibitor CHIR-124 Shows Multistage Activity Against via Dual Inhibition of Ark1 and Hemozoin Formation.
Kathryn J Wicht, John G Woodland, Larnelle F Garnie, Henrico Langeveld, Dale Taylor, Jacquin C Niles

bioRxiv· July 2025

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