Publications by authors named "JR Spence"

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Surface expression of antitoxin on engineered bacteria neutralizes genotoxic colibactin in the gut.
Shaobo Yang, Zongqi Wang, Chengyuan Fang, Mengdi Yang, Saleh Khawaled, Jason R Spence

Nat Microbiol· December 2025

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Publisher Correction: Surface expression of antitoxin on engineered bacteria neutralizes genotoxic colibactin in the gut.
Shaobo Yang, Zongqi Wang, Chengyuan Fang, Mengdi Yang, Saleh Khawaled, Jason R Spence

Nat Microbiol· December 2025

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RUNX2 promotes epigenetic WNT signaling in inflamed intestinal epithelial cells.
Rodolfo I Cabrera-Silva, Zachary S Wilson, Jael Miranda, Shuling Fan, Michael Dame, Jason R Spence

bioRxiv· November 2025

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Carbon dynamics following variable retention harvesting in boreal mixedwood forests.
Linhao Wu, J A Colin Bergeron, S Ellen Macdonald, Charles A Nock, David W Langor, John R Spence

Ecol Appl· October 2025

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Clinical Interventions and Inflammatory Signaling Shape the Transcriptional and Cellular Architecture of the Early Postnatal Lung.
Tristan Frum, Angeline Wu, Marcela S Ymayo, Yu-Hwai Tsai, Sha Huang, Jason R Spence

bioRxiv· October 2025

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Human-mouse cross-species comparison identifies common and unique aspects of intestinal mesenchyme development.
Kelli Johnson, Xiangning Dong, Zhiwei Xiao, Hamza Islam, Meghan Anderman, Jason R Spence

bioRxiv· September 2025

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A scalable long-term model of human colonic epithelium with continuous barrier function.
Ashley J Cuttitta, Sophia R Meyer, Tristan Frum, Bhargavasai Gunuguntla, Angeline Wu, Jason R Spence

bioRxiv· September 2025

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Recent evolution of the developing human intestine affects metabolic and barrier functions.
Qianhui Yu, Umut Kilik, Stefano Secchia, Lukas Adam, Yu-Hwai Tsai, Jason R Spence

Science· August 2025

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Fibroblast lipid metabolism through ACSL4 regulates epithelial sensitivity to ferroptosis in IBD.
Wesley Huang, Yuezhong Zhang, Nupur K Das, Sumeet Solanki, Chesta Jain, Jason R Spence

Nat Metab· July 2025

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Mapping mesenchymal diversity in the developing human intestine and organoids.
Kelli F Johnson, Xiangning Dong, Yu-Hwai Tsai, Angeline Wu, Sydney G Clark, Jason R Spence

bioRxiv· July 2025

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SOX9 suppresses colon cancer via inhibiting epithelial-mesenchymal transition and SOX2 induction.
Ying Feng, Ningxin Zhu, Karan Bedi, Jinju Li, Chamila Perera, Jason R Spence

J Clin Invest· June 2025

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Lysophosphatidic acid and sphingosine-1-phosphate are apical polarity cues in multiple organoid systems.
Andrew M Tidball, Jinghui Luo, J Clayton Walker, Charlotte Y Yang, Keithan Lee, Ryan C Spencer, Jason R Spence

Cell Rep· June 2025

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An integrated transcriptomic cell atlas of human endoderm-derived organoids.
Quan Xu, Lennard Halle, Soroor Hediyeh-Zadeh, Merel Kuijs, Rya Riedweg, Jason R Spence

Nat Genet· May 2025

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Coordinated differentiation of human intestinal organoids with functional enteric neurons and vasculature.
Charlie J Childs, Holly M Poling, Kevin Chen, Yu-Hwai Tsai, Angeline Wu, Ryan C Spencer, Jason R Spence

Cell Stem Cell· April 2025

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Strain- and vaccine-specific effects of serum antibodies in the protection of intestinal SARS-CoV-2 infection.
M D Cherne, D Snyder, B Sidar, K Blackwell, B Jenkins, J R Spence

medRxiv· March 2025

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Nascent matrix deposition supports alveolar organoid formation from aggregates in synthetic hydrogels.
Madeline K Eiken, Charlie J Childs, Lindy K Brastrom, Tristan Frum, Eleanor M Plaster, Ryan C Spencer, Jason R Spence

Stem Cell Reports· January 2025

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Dynamic Reprogramming of Stromal Pdgfra-expressing cells during WNT-Mediated Transformation of the Intestinal Epithelium.
O Pellon-Cardenas, P Rout, S Hassan, E Fokas, He Ping, J R Spence

bioRxiv· January 2025

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Polymer design of microwell hydrogels influences epithelial-mesenchymal interactions during human bronchosphere formation.
Madeline K Eiken, Justin E Levine, Shinyeong Lee, Samantha Lukpat, Eleanor M Plaster, Jason R Spence

Adv Nanobiomed Res· January 2025

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Neutrophil prime unique transcriptional responses in intestinal organoids during infection with nontyphoidal serovars.
Anna-Lisa E Lawrence, Ryan P Berger, David R Hill, Sha Huang, Veda K Yadagiri, Jason R Spence

mSphere· December 2024

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GRAIL1 Stabilizes Misfolded Mutant p53 through a Ubiquitin Ligase-Independent, Chaperone Regulatory Function.
Paramita Ray, Sangeeta Jaiswal, Daysha Ferrer-Torres, Zhuwen Wang, Derek Nancarrow, Jason R Spence

Mol Cancer Res· November 2024

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Introducing prediction intervals for sample means.
Molly E Contini, Jeffrey R Spence, David J Stanley

Biochem Med (Zagreb)· October 2024

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APOE-NOTCH axis governs elastogenesis during human cardiac valve remodeling.
Ziyi Liu, Yu Liu, Zhiyun Yu, Cheng Tan, Nicole Pek, Jason R Spence

Nat Cardiovasc Res· August 2024

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Differential Bioactivation Profiles of Different GS-441524 Prodrugs in Cell and Mouse Models: ProTide Prodrugs with High Cell Permeability and Susceptibility to Cathepsin A Are More Efficient in Delivering Antiviral Active Metabolites to the Lung.
Jiapeng Li, Daniel Macedo de Melo Jorge, Weiwen Wang, Shuxin Sun, Tristan Frum, Jason R Spence

J Med Chem· May 2024

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A patterned human neural tube model using microfluidic gradients.
Xufeng Xue, Yung Su Kim, Alfredo-Isaac Ponce-Arias, Richard O'Laughlin, Robin Zhexuan Yan, Jason R Spence

Nature· April 2024

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Nascent matrix deposition supports alveolar organoid formation from aggregates in synthetic hydrogels.
Madeline K Eiken, Charlie J Childs, Lindy K Brastrom, Tristan Frum, Eleanor M Plaster, Jason R Spence

bioRxiv· March 2024

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