Publications by authors named "James Pippin"

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3D chromatin-based variant-to-gene maps across 57 human cell types reveal the cellular and genetic architecture of autoimmune disease susceptibility.
Khanh B Trang, Prabhat Sharma, Laura Cook, Zachary Mount, Rajan M Thomas, James A Pippin

Genome Biol· December 2025

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GWAS-informed data integration and non-coding CRISPRi screen illuminate genetic etiology of bone mineral density.
Mitchell Conery, James A Pippin, Yadav Wagley, Khanh Trang, Matthew C Pahl

Genome Biol· October 2025

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Large-scale multiomic analysis identifies non-coding somatic driver mutations and nominates as a driver gene for pancreatic ductal adenocarcinoma.
Jun Zhong, Aidan O'Brien, Minal B Patel, Daina Eiser, Michael Mobaraki, James A Pippin

Gut· October 2025

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Shared and unique 3D genomic features of substance use disorders across multiple cell types.
Khanh B Trang, Alessandra Chesi, Sylvanus Toikumo, James A Pippin, Matthew C Pahl

medRxiv· June 2025

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3D chromatin-based variant-to-gene maps across 57 human cell types reveal the cellular and genetic architecture of autoimmune disease susceptibility.
Khanh B Trang, Prabhat Sharma, Laura Cook, Zachary Mount, Rajan M Thomas, James A Pippin

medRxiv· May 2025

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Multimodal analysis of hematopoiesis reveals blood cell-specific genetic impacts on complex disease traits.
Rong Qiu, Khanh B Trang, Carson Shalaby, James A Pippin, James Garifallou

bioRxiv· May 2025

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Trans-ancestry genome-wide association meta-analysis of gallstone disease.
Junghyun Lim, Marijana Vujkovic, Michael G Levin, Kim Lorenz, Benjamin F Voight, James A Pippin

medRxiv· March 2025

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3D genomic features across >50 diverse cell types reveal insights into the genomic architecture of childhood obesity.
Khanh B Trang, Matthew C Pahl, James A Pippin, Chun Su, Sheridan H Littleton

Elife· January 2025

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GWAS-Informed data integration and non-coding CRISPRi screen illuminate genetic etiology of bone mineral density.
Mitchell Conery, James A Pippin, Yadav Wagley, Khanh Trang, Matthew C Pahl

bioRxiv· December 2024

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Implicating type 2 diabetes effector genes in relevant metabolic cellular models using promoter-focused Capture-C.
Nicholas A Wachowski, James A Pippin, Keith Boehm, Sumei Lu, Michelle E Leonard

Diabetologia· December 2024

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Dynamic chromatin architecture identifies new autoimmune-associated enhancers for and novel genes regulating CD4+ T cell activation.
Matthew C Pahl, Prabhat Sharma, Rajan M Thomas, Zachary Thompson, Zachary Mount, James A Pippin

Elife· September 2024

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Large-scale multi-omic analysis identifies noncoding somatic driver mutations and nominates as a driver gene for pancreatic ductal adenocarcinoma.
Jun Zhong, Aidan O'Brien, Minal Patel, Daina Eiser, Michael Mobaraki, James A Pippin

medRxiv· September 2024

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3D genomic features across >50 diverse cell types reveal insights into the genomic architecture of childhood obesity.
Khanh B Trang, Matthew C Pahl, James A Pippin, Chun Su, Sheridan H Littleton

medRxiv· August 2024

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Variant-to-function mapping of late-onset Alzheimer's disease GWAS signals in human microglial cell models implicates at the locus.
Elizabeth A Burton, Mariana Argenziano, Kieona Cook, Molly Ridler, Sumei Lu, James A Pippin

bioRxiv· August 2024

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Perturbation of the insomnia WDR90 genome-wide association studies locus pinpoints rs3752495 as a causal variant influencing distal expression of neighboring gene, PIG-Q.
Shilpa Sonti, Sheridan H Littleton, Matthew C Pahl, Amber J Zimmerman, Alessandra Chesi, James A Pippin

Sleep· July 2024

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Osteoporosis GWAS-implicated locus contextually regulates osteoblastic and chondrogenic fate of mesenchymal stem/progenitor cells through oscillating miR-199a-5p levels.
Gurcharan Kaur, James A Pippin, Solomon Chang, Justin Redmond, Alessandra Chesi

JBMR Plus· May 2024

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Variant-to-function analysis of the childhood obesity chr12q13 locus implicates rs7132908 as a causal variant within the 3' UTR of FAIM2.
Sheridan H Littleton, Khanh B Trang, Christina M Volpe, Kieona Cook, Nicole DeBruyne, James A Pippin

Cell Genom· May 2024

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Variant to gene mapping for carpal tunnel syndrome risk loci implicates skeletal muscle regulatory elements.
Matthew C Pahl, Lin Liu, James A Pippin, Yadav Wagley, Keith Boehm

EBioMedicine· March 2024

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Perturbation of the insomnia GWAS locus pinpoints rs3752495 as a causal variant influencing distal expression of neighboring gene, .
Shilpa Sonti, Sheridan H Littleton, Matthew C Pahl, Amber J Zimmerman, Alessandra Chesi, James A Pippin

bioRxiv· August 2023

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Variant-to-function analysis of the childhood obesity chr12q13 locus implicates rs7132908 as a causal variant within the 3' UTR of .
Sheridan H Littleton, Khanh B Trang, Christina M Volpe, Kieona Cook, Nicole DeBruyne, James A Pippin

bioRxiv· August 2023

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Patient-derived Colonoids From Disease-spared Tissue Retain Inflammatory Bowel Disease-specific Transcriptomic Signatures.
Tatiana A Karakasheva, Yusen Zhou, Hongbo M Xie, Gloria E Soto, Tiana D Johnson, James A Pippin

Gastro Hep Adv· May 2023

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Variant-to-gene mapping followed by cross-species genetic screening identifies GPI-anchor biosynthesis as a regulator of sleep.
Justin Palermo, Alessandra Chesi, Amber Zimmerman, Shilpa Sonti, Matthew C Pahl, James A Pippin

Sci Adv· January 2023

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3D chromatin maps of the human pancreas reveal lineage-specific regulatory architecture of T2D risk.
Chun Su, Long Gao, Catherine L May, James A Pippin, Keith Boehm

Cell Metab· September 2022

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Variant-to-gene-mapping analyses reveal a role for pancreatic islet cells in conferring genetic susceptibility to sleep-related traits.
Chiara Lasconi, Matthew C Pahl, James A Pippin, Chun Su, Matthew E Johnson

Sleep· August 2022

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Implicating effector genes at COVID-19 GWAS loci using promoter-focused Capture-C in disease-relevant immune cell types.
Matthew C Pahl, Carole Le Coz, Chun Su, Prabhat Sharma, Rajan M Thomas, James A Pippin

Genome Biol· June 2022

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