Publications by authors named "Jan-Wouter Drijfhout"

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Preclinical development and clinical safety assessment of a synthetic peptide conjugate enabling endogenous antibody binding to promote innate receptor engagement.
Erika A K Fletcher, Robert A Cordfunke, Aikaterini Nasi, Gunilla Törnqvist, Rob R P M Valentijn, Jan Wouter Drijfhout

Mol Ther Oncol· June 2025

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Amelioration of a von Willebrand disease type 2B phenotype in vivo upon treatment with allele-selective siRNAs.
Noa A Linthorst, Yvonne K Jongejan, Richard J Dirven, Sebastiaan N J Laan, Ruben Bierings, Jan Wouter Drijfhout

Blood Adv· January 2025

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C-Terminal PEGylation Improves SAAP-148 Peptide's Immunomodulatory Activities.
Miriam E van Gent, Bep Schonkeren-Ravensbergen, Asma Achkif, Daan Beentjes, Natasja Dolezal, Jan Wouter Drijfhout

J Innate Immun· December 2023

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Encapsulation in oleyl-modified hyaluronic acid nanogels substantially improves the clinical potential of the antimicrobial peptides SAAP-148 and Ab-Cath.
Miriam E van Gent, Sylvia N Klodzinska, Jan Wouter Drijfhout, Hanne M Nielsen, Peter H Nibbering

Eur J Pharm Biopharm· December 2023

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Novel Antibacterial Agents SAAP-148 and Halicin Combat Gram-Negative Bacteria Colonizing Catheters.
Nesrine Bouhrour, Tanny J K van der Reijden, Michella M Voet, Bep Schonkeren-Ravensbergen, Robert A Cordfunke, Jan Wouter Drijfhout

Antibiotics (Basel)· December 2023

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Encapsulation into hyaluronic acid-based nanogels improves the selectivity index of the snake cathelicidin Ab-Cath.
Miriam E van Gent, Sylvia N Kłodzińska, Maureen Severin, Muhanad Ali, Bjorn R van Doodewaerd, Jan Wouter Drijfhout

Nanomedicine· August 2023

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Bactericidal Activity to : Different Modes of Action of Two 24-Mer Peptides SAAP-148 and OP-145, Both Derived from Human Cathelicidine LL-37.
Ayse Ön, Djenana Vejzovic, James Jennings, Lena Parigger, Robert A Cordfunke, Jan Wouter Drijfhout

Antibiotics (Basel)· July 2023

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Comparison of methods generating antibody-epitope conjugates for targeting cancer with virus-specific T cells.
Willemijn van der Wulp, Anna M Gram, Boris Bleijlevens, Renate S Hagedoorn, Can Araman, Jan Wouter Drijfhout

Front Immunol· June 2023

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CalcAMP: A New Machine Learning Model for the Accurate Prediction of Antimicrobial Activity of Peptides.
Colin Bournez, Martijn Riool, Leonie de Boer, Robert A Cordfunke, Leonie de Best, Jan Wouter Drijfhout

Antibiotics (Basel)· April 2023

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Physical and Functional Characterization of PLGA Nanoparticles Containing the Antimicrobial Peptide SAAP-148.
Muhanad Ali, Miriam E van Gent, Amy M de Waal, Bjorn R van Doodewaerd, Erik Bos, Jan Wouter Drijfhout

Int J Mol Sci· February 2023

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Encapsulation of SAAP-148 in Octenyl Succinic Anhydride-Modified Hyaluronic Acid Nanogels for Treatment of Skin Wound Infections.
Miriam E van Gent, Tom van Baaren, Sylvia N Kłodzińska, Muhanad Ali, Natasja Dolezal, Jan Wouter Drijfhout

Pharmaceutics· January 2023

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A third vaccination with a single T cell epitope confers protection in a murine model of SARS-CoV-2 infection.
Iris N Pardieck, Tetje C van der Sluis, Esmé T I van der Gracht, Dominique M B Veerkamp, Felix M Behr, Jan Wouter Drijfhout

Nat Commun· July 2022

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Synergism between the Synthetic Antibacterial and Antibiofilm Peptide (SAAP)-148 and Halicin.
Miriam E van Gent, Tanny J K van der Reijden, Patrick R Lennard, Adriëtte W de Visser, Bep Schonkeren-Ravensbergen, Jan Wouter Drijfhout

Antibiotics (Basel)· May 2022

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Membrane Activity of LL-37 Derived Antimicrobial Peptides against : Superiority of SAAP-148 over OP-145.
Paulina Piller, Heimo Wolinski, Robert A Cordfunke, Jan Wouter Drijfhout, Sandro Keller

Biomolecules· March 2022

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Development and Provisional Validation of a Multiplex LC-MRM-MS Test for Timely Kidney Injury Detection in Urine.
Tirsa T van Duijl, L Renee Ruhaak, Nico P M Smit, Mervin M Pieterse, Fred P H T M Romijn, Jan Wouter Drijfhout

J Proteome Res· December 2021

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Eradication of meticillin-resistant Staphylococcus aureus from human skin by the novel LL-37-derived peptide P10 in four pharmaceutical ointments.
Peter H Nibbering, Anikó Göblyös, Alwin E Adriaans, Robert A Cordfunke, Bep Ravensbergen, Jan Wouter Drijfhout

Int J Antimicrob Agents· November 2019

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Cationic Liposomes: A Flexible Vaccine Delivery System for Physicochemically Diverse Antigenic Peptides.
Jeroen Heuts, Eleni Maria Varypataki, Koen van der Maaden, Stefan Romeijn, Jan Wouter Drijfhout

Pharm Res· September 2018

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Cationic Amphipathic Antimicrobial Peptides Perturb the Inner Membrane of Germinated Spores Thus Inhibiting Their Outgrowth.
Soraya Omardien, Jan Wouter Drijfhout, Sebastian A Zaat, Stanley Brul

Front Microbiol· September 2018

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Formation of Immune Complexes with a Tetanus-Derived B Cell Epitope Boosts Human T Cell Responses to Covalently Linked Peptides in an Ex Vivo Blood Loop System.
Erika A K Fletcher, Wendy van Maren, Robert Cordfunke, Jasper Dinkelaar, Jeroen D C Codee, Jan Wouter Drijfhout

J Immunol· July 2018

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Specific T Cell Responses against Minor Histocompatibility Antigens Cannot Generally Be Explained by Absence of Their Allelic Counterparts on the Cell Surface.
Helena M Bijen, Chopie Hassan, Michel G D Kester, George M C Janssen, Pleun Hombrink, Jan Wouter Drijfhout

Proteomics· June 2018

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Abrogation of Immunogenic Properties of Gliadin Peptides through Transamidation by Microbial Transglutaminase Is Acyl-Acceptor Dependent.
Lin Zhou, Yvonne M C Kooy-Winkelaar, Robert A Cordfunke, Irina Dragan, Allan Thompson, Jan Wouter Drijfhout

J Agric Food Chem· August 2017

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The Breadth of Synthetic Long Peptide Vaccine-Induced CD8+ T Cell Responses Determines the Efficacy against Mouse Cytomegalovirus Infection.
Eleni Panagioti, Anke Redeker, Suzanne van Duikeren, Kees Lmc Franken, Jan Wouter Drijfhout

PLoS Pathog· September 2016

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Antimicrobial Peptide P60.4Ac-Containing Creams and Gel for Eradication of Methicillin-Resistant Staphylococcus aureus from Cultured Skin and Airway Epithelial Surfaces.
Elisabeth M Haisma, Anikó Göblyös, Bep Ravensbergen, Alwin E Adriaans, Robert A Cordfunke, Jan Wouter Drijfhout

Antimicrob Agents Chemother· July 2016

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Synergistic Activity of the Plant Defensin HsAFP1 and Caspofungin against Candida albicans Biofilms and Planktonic Cultures.
Kim Vriens, Tanne L Cools, Peta J Harvey, David J Craik, Pieter Spincemaille, Jan Wouter Drijfhout

PLoS One· May 2016

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Clostridium difficile secreted Pro-Pro endopeptidase PPEP-1 (ZMP1/CD2830) modulates adhesion through cleavage of the collagen binding protein CD2831.
Paul J Hensbergen, Oleg I Klychnikov, Dennis Bakker, Irina Dragan, Michelle L Kelly, Jan Wouter Drijfhout

FEBS Lett· December 2015

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