Publications by authors named "Javier Robles-Valero"

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A hotspot mutation targeting the R-RAS2 GTPase acts as a potent oncogenic driver in a wide spectrum of tumors.
Isabel Fernández-Pisonero, Laura Clavaín, Javier Robles-Valero, L Francisco Lorenzo-Martín, Rubén Caloto, Blanca Nieto, Carmen García-Macías, Clara L Oeste, Manuel Sánchez-Martín, Antonio Abad

Cell Rep· March 2022

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Ribosomal protein deficiencies linked to Diamond-Blackfan anemia induce distinctive alterations of ATF4 expression.
L Francisco Lorenzo-Martín, Javier Robles-Valero, Rosa Ramírez-Cota, Sonia G Gaspar, Pedro Fuentes

iScience· April 2025

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Characterization of the spectrum of trivalent VAV1-mutation-driven tumours using a gene-edited mouse model.
Javier Robles-Valero, Lucía Fernández-Nevado, Myriam Cuadrado, Luis Francisco Lorenzo-Martín, Isabel Fernández-Pisonero

Mol Oncol· October 2022

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Cancer-associated mutations in VAV1 trigger variegated signaling outputs and T-cell lymphomagenesis.
Javier Robles-Valero, Lucía Fernández-Nevado, L Francisco Lorenzo-Martín, Myriam Cuadrado, Isabel Fernández-Pisonero

EMBO J· November 2021

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VAV Proteins as Double Agents in Cancer: Oncogenes with Tumor Suppressor Roles.
Myriam Cuadrado, Javier Robles-Valero

Biology (Basel)· September 2021

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Distinct Roles of Vav Family Members in Adaptive and Innate Immune Models of Arthritis.
Javier Conde, Isabel Fernández-Pisonero, Myriam Cuadrado, Antonio Abad, Javier Robles-Valero

Biomedicines· June 2021

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VAV2 signaling promotes regenerative proliferation in both cutaneous and head and neck squamous cell carcinoma.
L Francisco Lorenzo-Martín, Natalia Fernández-Parejo, Mauricio Menacho-Márquez, Sonia Rodríguez-Fdez, Javier Robles-Valero

Nat Commun· September 2020

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Rho guanosine nucleotide exchange factors are not such bad guys after all in cancer.
Javier Robles-Valero, L Francisco Lorenzo-Martín, Isabel Fernández-Pisonero, Xosé R Bustelo

Small GTPases· July 2020

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Vav2 pharmaco-mimetic mice reveal the therapeutic value and caveats of the catalytic inactivation of a Rho exchange factor.
L Francisco Lorenzo-Martín, Sonia Rodríguez-Fdez, Salvatore Fabbiano, Antonio Abad, María C García-Macías, Javier Robles-Valero

Oncogene· July 2020

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Computational and Pharmacodynamics Characterization of 1A-116 Rac1 Inhibitor: Relevance of Trp56 in Its Biological Activity.
Nazareno González, Georgina A Cardama, Patricio Chinestrad, Javier Robles-Valero, Sonia Rodríguez-Fdez

Front Cell Dev Biol· April 2020

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Vav proteins maintain epithelial traits in breast cancer cells using miR-200c-dependent and independent mechanisms.
L Francisco Lorenzo-Martín, Carmen Citterio, Mauricio Menacho-Márquez, Javier Conde, Romain M Larive, Javier Robles-Valero

Oncogene· January 2019

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An unexpected tumor suppressor role for VAV1.
Xosé R Bustelo, L Francisco Lorenzo-Martín, Myriam Cuadrado, Isabel Fernández-Pisonero, Javier Robles-Valero

Mol Cell Oncol· February 2018

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A Paradoxical Tumor-Suppressor Role for the Rac1 Exchange Factor Vav1 in T Cell Acute Lymphoblastic Leukemia.
Javier Robles-Valero, L Francisco Lorenzo-Martín, Mauricio Menacho-Márquez, Isabel Fernández-Pisonero, Antonio Abad

Cancer Cell· November 2017

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Activating mutations and translocations in the guanine exchange factor VAV1 in peripheral T-cell lymphomas.
Francesco Abate, Ana C da Silva-Almeida, Sakellarios Zairis, Javier Robles-Valero, Lucile Couronne

Proc Natl Acad Sci U S A· January 2017

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Clathrin regulates lymphocyte migration by driving actin accumulation at the cellular leading edge.
Guillermo Ramírez-Santiago, Javier Robles-Valero, Giulia Morlino, Aranzazu Cruz-Adalia, Manuel Pérez-Martínez

Eur J Immunol· October 2016

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Immunosuppression-Independent Role of Regulatory T Cells against Hypertension-Driven Renal Dysfunctions.
Salvatore Fabbiano, Mauricio Menacho-Márquez, Javier Robles-Valero, Miguel Pericacho, Adela Matesanz-Marín

Mol Cell Biol· October 2015

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The disease-linked Glu-26-Lys mutant version of Coronin 1A exhibits pleiotropic and pathway-specific signaling defects.
Virginia Ojeda, Javier Robles-Valero, María Barreira, Xosé R Bustelo

Mol Biol Cell· August 2015

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Miro-1 links mitochondria and microtubule Dynein motors to control lymphocyte migration and polarity.
Giulia Morlino, Olga Barreiro, Francesc Baixauli, Javier Robles-Valero, José M González-Granado

Mol Cell Biol· April 2014

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Endosomal clathrin drives actin accumulation at the immunological synapse.
Carmen Calabia-Linares, Javier Robles-Valero, Hortensia de la Fuente, Manuel Perez-Martinez, Noa Martín-Cofreces

J Cell Sci· March 2011

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Integrin and CD3/TCR activation are regulated by the scaffold protein AKAP450.
Javier Robles-Valero, Noa B Martín-Cófreces, Amalia Lamana, Stephen Macdonald, Yuri Volkov

Blood· May 2010

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MTOC translocation modulates IS formation and controls sustained T cell signaling.
Noa B Martín-Cófreces, Javier Robles-Valero, J Román Cabrero, María Mittelbrunn, Mónica Gordón-Alonso

J Cell Biol· September 2008

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