Publications by authors named "Jean Macfadyen"

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Effects of Randomized Treatment With Icosapent Ethyl and a Mineral Oil Comparator on Interleukin-1β, Interleukin-6, C-Reactive Protein, Oxidized Low-Density Lipoprotein Cholesterol, Homocysteine, Lipoprotein(a), and Lipoprotein-Associated Phospholipase A2: A REDUCE-IT Biomarker Substudy.
Paul M Ridker, Nader Rifai, Jean MacFadyen, Robert J Glynn, Lixia Jiao, Ph Gabriel Steg, Michael Miller, Eliot A Brinton, Terry A Jacobson, Jean-Claude Tardif

Circulation· August 2022

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Dual versus monotherapy with SGLT2 inhibitor and GLP-1 receptor agonist:PRECIDENTD pragmatic randomized trial.
Deborah J Wexler, Lindsay S Mayberry, Lyndsay A Nelson, Jeremy Lema-Driscoll, Ligia C Flores, Jean G MacFadyen

Am Heart J· December 2025

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Expanding the triglyceride range in clinical trials: therapeutic opportunities.
Ask T Nordestgaard, Aruna D Pradhan, Brendan M Everett, Jean G MacFadyen, Deepak L Bhatt

Eur Heart J· May 2025

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Associations of Serum Urate and Cardiovascular Events in a Clinical Trial of Interleukin-1β Blockade.
Nicholas H Adamstein, Jean G MacFadyen, Brittany N Weber, Peter Libby, Daniel H Solomon

JACC Adv· March 2025

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Effect of Pemafibrate on Diabetic Foot Ulceration and Gangrene: An Exploratory Analysis From PROMINENT.
Lucas L Marinho, Brendan M Everett, Aaron W Aday, Frank L J Visseren, Jean G MacFadyen

J Am Coll Cardiol· July 2024

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Effect of canakinumab on frailty: A post hoc analysis of the CANTOS trial.
Ariela R Orkaby, Aerin Thomson, Jean MacFadyen, Richard Besdine, Daniel E Forman

Aging Cell· January 2024

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Canakinumab's Effect Against Subsequent Gout Flares and High-Sensitivity C-Reactive Protein Levels: A Causal Mediation Analysis.
Kazuki Yoshida, Robert J Glynn, Hyon K Choi, Brendan M Everett, Yi Li, Jean G MacFadyen

Arthritis Care Res (Hoboken)· April 2023

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Inflammation and cholesterol as predictors of cardiovascular events among patients receiving statin therapy: a collaborative analysis of three randomised trials.
Paul M Ridker, Deepak L Bhatt, Aruna D Pradhan, Robert J Glynn, Jean G MacFadyen

Lancet· April 2023

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Inflammation drives residual risk in chronic kidney disease: a CANTOS substudy.
Paul M Ridker, Katherine R Tuttle, Vlado Perkovic, Peter Libby, Jean G MacFadyen

Eur Heart J· December 2022

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Rosuvastatin for the prevention of venous thromboembolism: a pooled analysis of the HOPE-3 and JUPITER randomized controlled trials.
Philip Joseph, Robert Glynn, Eva Lonn, Chinthanie Ramasundarahettige, John Eikelboom, Jean MacFadyen

Cardiovasc Res· February 2022

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Adverse effects related to methotrexate polyglutamate levels: adjudicated results from the cardiovascular inflammation reduction trial.
Chang Xu, Jacob Selhub, Paul Jacques, Nina P Paynter, Jean G MacFadyen

Rheumatology (Oxford)· June 2021

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The neutrophil-lymphocyte ratio and incident atherosclerotic events: analyses from five contemporary randomized trials.
Nicholas H Adamstein, Jean G MacFadyen, Lynda M Rose, Robert J Glynn, Amit K Dey

Eur Heart J· March 2021

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Adverse Effects of Low-Dose Methotrexate in a Randomized Double-Blind Placebo-Controlled Trial: Adjudicated Hematologic and Skin Cancer Outcomes in the Cardiovascular Inflammation Reduction Trial.
Kathleen M M Vanni, Nancy Berliner, Nina P Paynter, Robert J Glynn, Jean MacFadyen

ACR Open Rheumatol· December 2020

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Inhibition of Interleukin-1β and Reduction in Atherothrombotic Cardiovascular Events in the CANTOS Trial.
Brendan M Everett, Jean G MacFadyen, Tom Thuren, Peter Libby, Robert J Glynn

J Am Coll Cardiol· October 2020

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Comparison of interleukin-6, C-reactive protein, and low-density lipoprotein cholesterol as biomarkers of residual risk in contemporary practice: secondary analyses from the Cardiovascular Inflammation Reduction Trial.
Paul M Ridker, Jean G MacFadyen, Robert J Glynn, Gary Bradwin, Ahmed A Hasan

Eur Heart J· August 2020

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Residual inflammatory risk associated with interleukin-18 and interleukin-6 after successful interleukin-1β inhibition with canakinumab: further rationale for the development of targeted anti-cytokine therapies for the treatment of atherothrombosis.
Paul M Ridker, Jean G MacFadyen, Tom Thuren, Peter Libby

Eur Heart J· June 2020

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Effects of Interleukin-1β Inhibition on Incident Anemia: Exploratory Analyses From a Randomized Trial.
Mounica Vallurupalli, Jean G MacFadyen, Robert J Glynn, Tom Thuren, Peter Libby

Ann Intern Med· April 2020

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Adverse Effects of Low-Dose Methotrexate: A Randomized Trial.
Daniel H Solomon, Robert J Glynn, Elizabeth W Karlson, Fengxin Lu, Cassandra Corrigan, Jean MacFadyen

Ann Intern Med· March 2020

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Effects of Interleukin-1β Inhibition on Blood Pressure, Incident Hypertension, and Residual Inflammatory Risk: A Secondary Analysis of CANTOS.
Alexander Mk Rothman, Jean MacFadyen, Tom Thuren, Alastair Webb, David G Harrison

Hypertension· February 2020

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Exercise reduces inflammatory cell production and cardiovascular inflammation via instruction of hematopoietic progenitor cells.
Vanessa Frodermann, David Rohde, Gabriel Courties, Nicolas Severe, Maximilian J Schloss, Jean MacFadyen

Nat Med· November 2019

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Low-Dose Methotrexate for the Prevention of Atherosclerotic Events.
Paul M Ridker, Brendan M Everett, Aruna Pradhan, Jean G MacFadyen, Daniel H Solomon

N Engl J Med· February 2019

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Modulation of the interleukin-6 signalling pathway and incidence rates of atherosclerotic events and all-cause mortality: analyses from the Canakinumab Anti-Inflammatory Thrombosis Outcomes Study (CANTOS).
Paul M Ridker, Peter Libby, Jean G MacFadyen, Tom Thuren, Christie Ballantyne

Eur Heart J· October 2018

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Relationship of Interleukin-1β Blockade With Incident Gout and Serum Uric Acid Levels: Exploratory Analysis of a Randomized Controlled Trial.
Daniel H Solomon, Robert J Glynn, Jean G MacFadyen, Peter Libby, Tom Thuren

Ann Intern Med· October 2018

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Inhibition of Interleukin-1β by Canakinumab and Cardiovascular Outcomes in Patients With Chronic Kidney Disease.
Paul M Ridker, Jean G MacFadyen, Robert J Glynn, Wolfgang Koenig, Peter Libby

J Am Coll Cardiol· May 2018

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