Publications by authors named "John D Clarke"

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Multi-targeted prevention of cancer by sulforaphane.
John D Clarke, Roderick H Dashwood, Emily Ho

October 2008

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From Discovery to Translation: Endogenous Substrates of OAT1 and OAT3 as Clinical Biomarkers for Renal Secretory Function.
Aarzoo Thakur, Dilip K Singh, Katherine D Hart, Emese Kis, Zsuzsanna Gáborik, John D Clarke

Clin Pharmacol Ther· September 2025

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Corrigendum to 'A gut response: Application of human enteroid monolayers to probe the mechanism of the goldenseal-mediated inhibition of metformin intestinal absorption' [The Journal of Pharmacology and Experimental Therapeutics 392 (2025) 103597].
Christopher M Arian, Eimear T O'Mahony, Preston K Manwill, Tyler N Graf, Nicholas H Oberlies, John D Clarke

J Pharmacol Exp Ther· July 2025

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A gut response: Application of human enteroid monolayers to probe the mechanism of the goldenseal-mediated inhibition of metformin intestinal absorption.
Christopher M Arian, Eimear T O'Mahony, Preston K Manwill, Tyler N Graf, Nicholas H Oberlies, John D Clarke

J Pharmacol Exp Ther· June 2025

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From discovery to translation: Endogenous substrates of OAT1 and OAT3 as clinical biomarkers for renal secretory function.
Aarzoo Thakur, Dilip K Singh, Katherine D Hart, Emese Kis, Zsuzsanna Gáborik, John D Clarke

bioRxiv· February 2025

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Microcystin-LR activates serine/threonine kinases and alters the phosphoproteome in human HepaRG cells.
Victor O Ikumawoyi, Katherine D Lynch, Dayne T Iverson, M Ridge Call, Guihua Eileen Yue, John D Clarke

Toxicon· October 2024

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A broadly reactive ultralong bovine antibody that can determine the integrity of foot-and-mouth disease virus capsids.
John D Clarke, Helen M E Duyvesteyn, Eva Perez-Martin, Undīne Latišenko, Claudine Porta

J Gen Virol· October 2024

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Mechanisms of intestinal pharmacokinetic natural product-drug interactions.
Victoria O Oyanna, John D Clarke

Drug Metab Rev· August 2024

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The impact of exchanging the light and heavy chains on the structures of bovine ultralong antibodies.
John D Clarke, Alice Douangamath, Halina Mikolajek, Marie Bonnet-Di Placido, Jingshan Ren

Acta Crystallogr F Struct Biol Commun· July 2024

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Rifampin- and Silymarin-Mediated Pharmacokinetic Interactions of Exogenous and Endogenous Substrates in a Transgenic OATP1B Mouse Model.
Baron J Bechtold, Katherine D Lynch, Victoria O Oyanna, M Ridge Call, Tyler N Graf, John D Clarke

Mol Pharm· May 2024

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Pharmacokinetic Effects of Different Models of Nonalcoholic Fatty Liver Disease in Transgenic Humanized OATP1B Mice.
Baron J Bechtold, Katherine D Lynch, Victoria O Oyanna, M Ridge Call, Laura A White, John D Clarke

Drug Metab Dispos· April 2024

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Green Tea Catechins Decrease Solubility of Raloxifene In Vitro and Its Systemic Exposure in Mice.
Victoria O Oyanna, Baron J Bechtold, Katherine D Lynch, M Ridge Call, Tyler N Graf, John D Clarke

Pharm Res· March 2024

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Goldenseal-Mediated Inhibition of Intestinal Uptake Transporters Decreases Metformin Systemic Exposure in Mice.
Victoria O Oyanna, Kenisha Y Garcia-Torres, Baron J Bechtold, Katherine D Lynch, M Ridge Call, John D Clarke

Drug Metab Dispos· November 2023

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Co-consuming green tea with raloxifene decreases raloxifene systemic exposure in healthy adult participants.
John D Clarke, Sabrina M Judson, Dan-Dan Tian, Trevor O Kirby, Rakshit S Tanna

Clin Transl Sci· October 2023

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Protein-to-structure pipeline for ambient-temperature in situ crystallography at VMXi.
Halina Mikolajek, Juan Sanchez-Weatherby, James Sandy, Richard J Gildea, Ivan Campeotto, John D Clarke

IUCrJ· July 2023

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Involvement of the p38/MK2 Pathway in MCLR Hepatotoxicity Revealed through MAPK Pharmacological Inhibition and Phosphoproteomics in HepaRG Cells.
Katherine D Lynch, Dayne T Iverson, Namrata K Bachhav, Michael Ridge Call, Guihua Eileen Yue, John D Clarke

Int J Mol Sci· July 2023

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Pandemic Response Officers: Integration Between Medical, Public Health, and Higher Education Systems to Expedite Prevention and Response.
Anne C Jones, Genevive R Meredith, Donna Leong, Sabine Jamal, Rachel Buckwalter, John D Clarke

J Public Health Manag Pract· May 2023

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MCLR-elicited hepatic fibrosis and carcinogenic gene expression changes persist in rats with diet-induced nonalcoholic steatohepatitis through a 4-week recovery period.
Tarana Arman, J Allen Baron, Katherine D Lynch, Laura A White, Johnny Aldan, John D Clarke

Toxicology· December 2021

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Microcystin Toxicokinetics, Molecular Toxicology, and Pathophysiology in Preclinical Rodent Models and Humans.
Tarana Arman, John D Clarke

Toxins (Basel)· July 2021

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Hepatic organic anion transporting polypeptides mediate disposition of milk thistle flavonolignans and pharmacokinetic silymarin-drug interactions.
Katherine D Lynch, Michelle L Montonye, Dan-Dan Tian, Tarana Arman, Victoria O Oyanna, John D Clarke

Phytother Res· June 2021

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Sub-chronic microcystin-LR renal toxicity in rats fed a high fat/high cholesterol diet.
Tarana Arman, Katherine D Lynch, Michael Goedken, John D Clarke

Chemosphere· April 2021

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Modeling Pharmacokinetic Natural Product-Drug Interactions for Decision-Making: A NaPDI Center Recommended Approach.
Emily J Cox, Dan-Dan Tian, John D Clarke, Allan E Rettie, Jashvant D Unadkat

Pharmacol Rev· April 2021

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Interaction of Oatp1b2 expression and nonalcoholic steatohepatitis on pravastatin plasma clearance.
Erica L Toth, John D Clarke, Iván L Csanaky, Nathan J Cherrington

Biochem Pharmacol· April 2020

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A Pharmacokinetic Natural Product-Disease-Drug Interaction: A Double Hit of Silymarin and Nonalcoholic Steatohepatitis on Hepatic Transporters in a Rat Model.
Michelle L Montonye, Dan-Dan Tian, Tarana Arman, Katherine D Lynch, Bruno Hagenbuch, John D Clarke

J Pharmacol Exp Ther· November 2019

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Sub-Chronic Microcystin-LR Liver Toxicity in Preexisting Diet-Induced Nonalcoholic Steatohepatitis in Rats.
Tarana Arman, Katherine D Lynch, Michelle L Montonye, Michael Goedken, John D Clarke

Toxins (Basel)· July 2019

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Nonalcoholic fatty liver disease alters microcystin-LR toxicokinetics and acute toxicity.
John D Clarke, Anika Dzierlenga, Tarana Arman, Erica Toth, Hui Li

Toxicon· April 2019

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