Publications by authors named "John D Overton"

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Distribution and clinical impact of functional variants in 50,726 whole-exome sequences from the DiscovEHR study.
Frederick E Dewey, Michael F Murray, John D Overton, Lukas Habegger, Joseph B Leader, Samantha N Fetterolf, Colm O'Dushlaine, Cristopher V Van Hout, Jeffrey Staples, Claudia Gonzaga-Jauregui

December 2016

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A rare variant in associated with depression in a Mennonite pedigree causes habenula hyperactivity and stress sensitivity in mice.
Bradley R Miller, Claudia Gonzaga-Jauregui, Karlla W Brigatti, Job de Jong, Robert S Breese, John D Overton

Proc Natl Acad Sci U S A· April 2025

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Deficiency of Peptidylglycine-alpha-amidating Monooxygenase, a Cause of Sarcopenic Diabetes Mellitus.
Alice Giontella, Mikael Åkerlund, Kevin Bronton, Cristiano Fava, Luca A Lotta, John D Overton

J Clin Endocrinol Metab· February 2025

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Author Correction: A deep catalogue of protein-coding variation in 983,578 individuals.
Kathie Y Sun, Xiaodong Bai, Siying Chen, Suying Bao, Chuanyi Zhang, John D Overton

Nature· January 2025

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Author Correction: Common and rare variant associations with clonal haematopoiesis phenotypes.
Michael D Kessler, Amy Damask, Sean O'Keeffe, Nilanjana Banerjee, Dadong Li, John D Overton

Nature· January 2025

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Yield of genetic association signals from genomes, exomes and imputation in the UK Biobank.
Sheila M Gaynor, Tyler Joseph, Xiaodong Bai, Yuxin Zou, Boris Boutkov, John D Overton

Nat Genet· November 2024

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Genetic risk factors for COVID-19 and influenza are largely distinct.
Jack A Kosmicki, Anthony Marcketta, Deepika Sharma, Silvio Alessandro Di Gioia, Samantha Batista, John D Overton

Nat Genet· August 2024

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A deep catalogue of protein-coding variation in 983,578 individuals.
Kathie Y Sun, Xiaodong Bai, Siying Chen, Suying Bao, Chuanyi Zhang, John D Overton

Nature· July 2024

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Converging evidence from exome sequencing and common variants implicates target genes for osteoporosis.
Sirui Zhou, Olukayode A Sosina, Jonas Bovijn, Laetitia Laurent, Vasundhara Sharma, John D Overton

Nat Genet· August 2023

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Author Correction: Common and rare variant associations with clonal haematopoiesis phenotypes.
Michael D Kessler, Amy Damask, Sean O'Keeffe, Nilanjana Banerjee, Dadong Li, John D Overton

Nature· March 2023

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Common and rare variant associations with clonal haematopoiesis phenotypes.
Michael D Kessler, Amy Damask, Sean O'Keeffe, Nilanjana Banerjee, Dadong Li, John D Overton

Nature· December 2022

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Multiancestry exome sequencing reveals INHBE mutations associated with favorable fat distribution and protection from diabetes.
Parsa Akbari, Olukayode A Sosina, Jonas Bovijn, Karl Landheer, Jonas B Nielsen, John D Overton

Nat Commun· August 2022

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Germline Mutations in and Protection against Liver Disease.
Niek Verweij, Mary E Haas, Jonas B Nielsen, Olukayode A Sosina, Minhee Kim, John D Overton

N Engl J Med· July 2022

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Within-sibship genome-wide association analyses decrease bias in estimates of direct genetic effects.
Laurence J Howe, Michel G Nivard, Tim T Morris, Ailin F Hansen, Humaira Rasheed, John D Overton

Nat Genet· May 2022

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Genome-wide analysis provides genetic evidence that ACE2 influences COVID-19 risk and yields risk scores associated with severe disease.
Julie E Horowitz, Jack A Kosmicki, Amy Damask, Deepika Sharma, Genevieve H L Roberts, John D Overton

Nat Genet· April 2022

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Association of Thyroid Function with Blood Pressure and Cardiovascular Disease: A Mendelian Randomization.
Alice Giontella, Luca A Lotta, John D Overton, Aris Baras, On Behalf Of Regeneron Genetics Center

J Pers Med· December 2021

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Exome sequencing and analysis of 454,787 UK Biobank participants.
Joshua D Backman, Alexander H Li, Anthony Marcketta, Dylan Sun, Joelle Mbatchou, John D Overton

Nature· November 2021

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Genome-wide association analysis of serum alanine and aspartate aminotransferase, and the modifying effects of BMI in 388k European individuals.
Chuan Gao, Anthony Marcketta, Joshua D Backman, Colm O'Dushlaine, Jeffrey Staples, John D Overton

Genet Epidemiol· September 2021

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Pan-ancestry exome-wide association analyses of COVID-19 outcomes in 586,157 individuals.
Jack A Kosmicki, Julie E Horowitz, Nilanjana Banerjee, Rouel Lanche, Anthony Marcketta, John D Overton

Am J Hum Genet· July 2021

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Causal Effect of Adiposity Measures on Blood Pressure Traits in 2 Urban Swedish Cohorts: A Mendelian Randomization Study.
Alice Giontella, Luca A Lotta, John D Overton, Aris Baras,

J Am Heart Assoc· July 2021

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Advancing human genetics research and drug discovery through exome sequencing of the UK Biobank.
Joseph D Szustakowski, Suganthi Balasubramanian, Erika Kvikstad, Shareef Khalid, Paola G Bronson, John D Overton

Nat Genet· July 2021

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Sequencing of 640,000 exomes identifies variants associated with protection from obesity.
Parsa Akbari, Ankit Gilani, Olukayode Sosina, Jack A Kosmicki, Lori Khrimian, John D Overton

Science· July 2021

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Mutation spectrum of NOD2 reveals recessive inheritance as a main driver of Early Onset Crohn's Disease.
Julie E Horowitz, Neil Warner, Jeffrey Staples, Eileen Crowley, Nehal Gosalia, John D Overton

Sci Rep· March 2021

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Clinical Evaluation of the Polygenetic Background of Blood Pressure in the Population-Based Setting.
Alice Giontella, Marketa Sjögren, Luca A Lotta, John D Overton, Aris Baras

Hypertension· January 2021

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Exome-wide evaluation of rare coding variants using electronic health records identifies new gene-phenotype associations.
Joseph Park, Anastasia M Lucas, Xinyuan Zhang, Kumardeep Chaudhary, Judy H Cho, John D Overton

Nat Med· January 2021

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Kidney disease genetic risk variants alter lysosomal beta-mannosidase () expression and disease severity.
Xiangchen Gu, Hongliu Yang, Xin Sheng, Yi-An Ko, Chengxiang Qiu, John D Overton

Sci Transl Med· January 2021

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