Publications by authors named "John Doench"

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Loss of NOTCH2 creates a TRIM28-dependent vulnerability in small cell lung cancer.
Deli Hong, Ying Lyu, Richa Nayak, Justin S Becker, Matthew A Booker, John G Doench

Dev Cell· December 2025

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Defining the Antitumor Mechanism of Action of a Clinical-stage Compound as a Selective Degrader of the Nuclear Pore Complex.
Linjie Yuan, Wenzhi Ji, Brendan G Dwyer, Joey Lu, Jing Bian, John G Doench

Cancer Discov· December 2025

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Sialyl-T Antigen: A Novel Red Blood Cell Determinant for Plasmodium falciparum Invasion.
Mahmoud Mikdar, Estela Shabani, Christof Grüring, Mudit Chaand, Usheer Kanjee, John G Doench

Am J Hematol· November 2025

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Activity-based selection for enhanced base editor mutational scanning.
Eleanor G Kaplan, Ryan J Steger, Spencer T Shah, Laura M Drepanos, Audrey L Griffith, John G Doench

Nat Genet· November 2025

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ER protein CLCC1 promotes nuclear envelope fusion in herpesviral and host processes.
Bing Dai, Adrian W Sperl, Lucas Polack, Isabel Mejia, Haley Dame, John G Doench

Nat Commun· November 2025

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Targeting G1-S-checkpoint-compromised cancers with cyclin A/B RxL inhibitors.
Shilpa Singh, Catherine E Gleason, Min Fang, Yasmin N Laimon, Vishal Khivansara, John G Doench

Nature· October 2025

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In vivo CRISPR screens identify modifiers of CAR T cell function in myeloma.
Nelson H Knudsen, Giulia Escobar, Felix Korell, Tamina Kienka, Celeste Nobrega, John G Doench

Nature· October 2025

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Genome-wide CRISPR interference screen identifies Clip2 as a novel regulator of osteocyte maturation and morphology.
Courtney M Mazur, Parthena E Kotsalidis, Majd George, Tom Whalley, Tadatoshi Sato, John G Doench

bioRxiv· October 2025

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Host cyclophilin-mediated maturation of an obligate intracellular bacterial surface virulence factor.
Brandon Sit, Allen G Sanderlin, Clara Y Zhu, Lauren E Bird, John G Doench

bioRxiv· October 2025

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Discovery of chromatin-based determinants of azacytidine and decitabine anti-cancer activity.
Rishi V Puram, Qiangzong Yin, YuhJong Liu, Justine C Rutter, Daniel Bondeson, John G Doench

bioRxiv· August 2025

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Morphological map of under- and overexpression of genes in human cells.
Srinivas Niranj Chandrasekaran, Eric Alix, John Arevalo, Adriana Borowa, Patrick J Byrne, John G Doench

Nat Methods· August 2025

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Requirement for Cyclin D1 Underlies Cell-Autonomous HIF2 Dependence in Kidney Cancer.
Nitin H Shirole, Devishi Kesar, Yenarae Lee, Amy Goodale, Sudeepa Syamala, John G Doench

Cancer Discov· July 2025

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HKU5 bat merbecoviruses engage bat and mink ACE2 as entry receptors.
Mia Madel Alfajaro, Emma L Keeler, Ning Li, Nicholas J Catanzaro, I-Ting Teng, John G Doench

Nat Commun· July 2025

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Sialylated CD43 is a glyco-immune checkpoint for macrophage phagocytosis.
Jooho Chung, Mounica Vallurupalli, Sarah Noel, Gail Schor, YuhJong Liu, John G Doench

bioRxiv· May 2025

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Multi-locus CRISPRi targeting with a single truncated guide RNA.
Molly M Moore, Siddarth Wekhande, Robbyn Issner, Alejandro Collins, Anna J Cruz, John G Doench

Nat Commun· February 2025

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VPS18 contributes to phagosome membrane integrity in -infected macrophages.
Charul Jani, Neha Jain, Amanda K Marsh, Pooja Uchil, Triet Doan, John G Doench

Sci Adv· January 2025

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In Vivo CRISPR Screening Reveals CHD7 as a Positive Regulator of Short-lived Effector Cells.
Martin W LaFleur, Jasmin M D'Andrea, Dillon G Patterson, Ivy S L Streeter, Matthew A Coxe, John G Doench

J Immunol· November 2024

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Neuropeptide signalling orchestrates T cell differentiation.
Yu Hou, Linyu Sun, Martin W LaFleur, Linglin Huang, Conner Lambden, John G Doench

Nature· November 2024

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A framework for target discovery in rare cancers.
Bingchen Li, Ananthan Sadagopan, Jiao Li, Yuqianxun Wu, Yantong Cui, John G Doench

bioRxiv· November 2024

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Epigenetic tuning of PD-1 expression improves exhausted T cell function and viral control.
Sarah A Weiss, Amy Y Huang, Megan E Fung, Daniela Martinez, Alex C Y Chen, John G Doench

Nat Immunol· October 2024

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Comprehensive structure-function analysis reveals gain- and loss-of-function mechanisms impacting oncogenic KRAS activity.
Jason J Kwon, Julien Dilly, Shengwu Liu, Eejung Kim, Yuemin Bian, John G Doench

bioRxiv· October 2024

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CLCC1 promotes membrane fusion during herpesvirus nuclear egress.
Bing Dai, Lucas Polack, Adrian Sperl, Haley Dame, Tien Huynh, John G Doench

bioRxiv· September 2024

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Cyclin A/B RxL Macrocyclic Inhibitors to Treat Cancers with High E2F Activity.
Shilpa Singh, Catherine E Gleason, Min Fang, Yasmin N Laimon, Vishal Khivansara, John G Doench

bioRxiv· August 2024

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Host cell CRISPR genomics and modelling reveal shared metabolic vulnerabilities in the intracellular development of Plasmodium falciparum and related hemoparasites.
Marina Maurizio, Maria Masid, Kerry Woods, Reto Caldelari, John G Doench

Nat Commun· July 2024

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