Publications by authors named "Jonathan A Javitch"

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7-Hydroxymitragynine Is an Active Metabolite of Mitragynine and a Key Mediator of Its Analgesic Effects.
Andrew C Kruegel, Rajendra Uprety, Steven G Grinnell, Cory Langreck, Elizabeth A Pekarskaya, Valerie Le Rouzic, Michael Ansonoff, Madalee M Gassaway, John E Pintar, Gavril W Pasternak

June 2019

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Parallel stopped-flow interrogation of diverse biological systems at the single-molecule scale.
Roman Kiselev, Ryan A Brady, Arnab Modak, F Aaron Cruz-Navarrete, Jose L Alejo, Jonathan A Javitch

Nat Methods· December 2025

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Chronic administration of methocinnamox, a mu-opioid receptor antagonist, reduces hedonic response without impacting motivation in mice.
Misbah Sheikh, Emily Cambre, Cory Langreck, Jonathan A Javitch, Sarah E Canetta

Psychopharmacology (Berl)· October 2025

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Novel, small molecules targeting the 5-HT receptor protect against stress-induced maladaptive behavior with efficacy across age.
Rebecca Ravenelle, Shi-Xian Deng, Mel Nelson, Maria H Pedersen, Indira Mendez-David, Jonathan A Javitch

bioRxiv· October 2025

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Habenular μ-opioid receptor knockout and chronic systemic receptor blockade promote negative affect and heighten nociceptive sensitivity.
Elizabeth A Pekarskaya, Julia Alexsandra Galiza Soares, Frances G Hough, Cory B Langreck, Jason M Tucciarone, Jonathan A Javitch

bioRxiv· August 2025

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Altered striatal dopamine regulation in knockout mice.
Nicole A Perry-Hauser, Arturo Torres-Herraez, Siham Boumhaouad, Emily A Makowicz, Daniel C Lowes, Jonathan A Javitch

bioRxiv· August 2025

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Mu Opioid Receptor Activation Is Required for NMDA Receptor Antagonist Effects on Stress-Induced Maladaptive Behavior.
Cory B Langreck, Briana K Chen, Victor M Luna, Mel Nelson, Gergely Turi, Jonathan A Javitch

Biol Psychiatry· July 2025

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CD33 and clusterin interact biophysically and genetically to modulate Alzheimer risk.
Roger B Dodd, Masahiro Enomoto, Ye Zhou, Kanayo Satoh, Yalun Zhang, Jonathan A Javitch

bioRxiv· July 2025

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Identification of a Lipid-Exposed Extrahelical Binding Site for Positive Allosteric Modulators of the Dopamine D Receptor.
Herman D Lim, Damian Bartuzi, Alastair C Keen, Caroline Rauffenbart, Jacqueline Glenn, Jonathan A Javitch

ACS Chem Neurosci· June 2025

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Conformational dynamics of the active state of β-arrestin 1.
Van Ngo, Wesley B Asher, Jonathan A Javitch, Lei Shi

bioRxiv· June 2025

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Complex G-protein signaling of the adhesion GPCR, ADGRA3.
Sofie M Bagger, Hannes Schihada, Anna L S Walser, Anna K Drzazga, Lukas Grätz, Jonathan A Javitch

J Biol Chem· May 2025

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N-terminal fragment shedding contributes to signaling of the full-length adhesion receptor ADGRL3.
Nicole A Perry-Hauser, Jonathan R Du Rand, Kuo Hao Lee, Lei Shi, Jonathan A Javitch

J Biol Chem· February 2025

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Elucidating the molecular logic of a metabotropic glutamate receptor heterodimer.
Xin Lin, Davide Provasi, Colleen M Niswender, Wesley B Asher, Jonathan A Javitch

Nat Commun· October 2024

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Oxa-Iboga alkaloids lack cardiac risk and disrupt opioid use in animal models.
Václav Havel, Andrew C Kruegel, Benjamin Bechand, Scot McIntosh, Leia Stallings, Jonathan A Javitch

Nat Commun· September 2024

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Promiscuous G-protein activation by the calcium-sensing receptor.
Hao Zuo, Jinseo Park, Aurel Frangaj, Jianxiang Ye, Guanqi Lu, Jonathan A Javitch

Nature· May 2024

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Molecular Design of SERTlight: A Fluorescent Serotonin Probe for Neuronal Labeling in the Brain.
Wei-Li Lee, Xavier Westergaard, Christopher Hwu, Jennifer Hwu, Tomas Fiala, Jonathan A Javitch

J Am Chem Soc· April 2024

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In Vitro Functional Profiling of Fentanyl and Nitazene Analogs at the μ-Opioid Receptor Reveals High Efficacy for Gi Protein Signaling.
Meng-Hua M Tsai, Li Chen, Michael H Baumann, Meritxell Canals, Jonathan A Javitch

ACS Chem Neurosci· February 2024

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Assessment of the potential of novel and classical opioids to induce respiratory depression in mice.
Rob Hill, Julie Sanchez, Laura Lemel, Mirjana Antonijevic, Yselkla Hosking, Jonathan A Javitch

Br J Pharmacol· December 2023

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Deciphering downstream receptor signaling.
Marta Filizola, Jonathan A Javitch

Science· December 2023

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The functional profiles of fentanyl and nitazene analogs at the μ-opioid receptor - high efficacy is dangerous regardless of signaling bias.
Meng-Hua M Tsai, Li Chen, Michael H Baumann, Meritxell Canals, Jonathan A Javitch

bioRxiv· November 2023

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Tianeptine promotes lasting antiallodynic effects in a mouse model of neuropathic pain.
Randal A Serafini, Molly Estill, Elizabeth A Pekarskaya, Farhana Sakloth, Li Shen, Jonathan A Javitch

Neuropsychopharmacology· October 2023

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In-Cell Arrestin-Receptor Interaction Assays.
Chen Zheng, Jonathan A Javitch, Nevin A Lambert, Prashant Donthamsetti, Vsevolod V Gurevich

Curr Protoc· October 2023

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Free fatty acid receptor 1 stimulates cAMP production and gut hormone secretion through Gq-mediated activation of adenylate cyclase 2.
Jacob Emil Petersen, Maria Hauge Pedersen, Oksana Dmytriyeva, Emilie Nellemose, Tulika Arora, Jonathan A Javitch

Mol Metab· August 2023

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Methods for automating the analysis of live-cell single-molecule FRET data.
Jozsef Meszaros, Peter Geggier, Jamie J Manning, Wesley B Asher, Jonathan A Javitch

Front Cell Dev Biol· August 2023

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Dopaminergic D2 receptor modulation of striatal cholinergic interneurons contributes to sequence learning.
Jessica Hotard Chancey, Christoph Kellendonk, Jonathan A Javitch, David M Lovinger

bioRxiv· August 2023

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Correction: Impact of membrane lipid polyunsaturation on dopamine D2 receptor ligand binding and signaling.
Marie-Lise Jobin, Véronique De Smedt-Peyrusse, Fabien Ducrocq, Rim Baccouch, Asma Oummadi, Jonathan A Javitch

Mol Psychiatry· May 2023

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