Publications by authors named "Karl Hoffmann"

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Novel 1-1,2,3-Triazole Derivatives of Praziquantel with TRPM Modulatory Activity and Antiparasitic Effects on Larvae, Juvenile, and Adult Worms of .
Floriano Paes Silva Junior, Rafael Ferreira Dantas, Sang-Kyu Park, Helen Whiteland, Camilla Thomaz da Silva Oliveira, Karl F Hoffmann

ACS Infect Dis· December 2025

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Glycan remodelling of live adult Schistosoma mansoni worms by chemical inhibition of α-mannosidases.
Eleonore B Kuhlemaijer, Tom Veldhuizen, Isabella A van Hulst, Tessa Liesker, Benjamin J Hulme, Karl F Hoffmann

Int J Parasitol· November 2025

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Frequency and treatment of venous thromboembolic events in patients with space-occupying brain infarction and decompressive craniectomy.
Alhuda Dabbagh, Janine Mielke, Katja S Mühlberg, Karl Titus Hoffmann, Dirk Lindner

Stroke Vasc Neurol· October 2025

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Use of P450 Enzymes for Late-Stage Functionalization in Drug Discovery.
Vincent Poon, Christopher Bailey, Sandra Carvalho, Stephen Patterson, James W B Fyfe, Karl F Hoffmann

J Med Chem· October 2025

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Anthelmintic evaluation of triterpenes derived from conifers (family Pinaceae) on the digenean parasite Fasciola hepatica.
Anand Chakroborty, Bismark Dankwa, Alessandra Crusco, Josephine E Forde-Thomas, Shashika Abeysekara, Karl F Hoffmann

Fitoterapia· September 2025

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Quinoxaline-based anti-schistosomal compounds have potent anti-plasmodial activity.
Mukul Rawat, Gilda Padalino, Edem Adika, John Okombo, Tomas Yeo, Karl F Hoffmann

PLoS Pathog· February 2025

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Compounds Containing 2,3-Bis(phenylamino) Quinoxaline Exhibit Activity Against Methicillin-Resistant Staphylococcus aureus, Enterococcus faecalis, and Their Biofilms.
Gilda Padalino, Katrina Duggan, Luis A J Mur, Jean-Yves Maillard, Andrea Brancale, Karl F Hoffmann

Microbiologyopen· December 2024

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Automated quantification of photoreceptor outer segments in developing and degenerating retinas on microscopy images across scales.
Suse Seidemann, Florian Salomon, Karl B Hoffmann, Thomas Kurth, Ivo F Sbalzarini

Front Mol Neurosci· May 2024

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Quinoxaline-Based Anti-Schistosomal Compounds Have Potent Anti-Malarial Activity.
Mukul Rawat, Gilda Padalino, Tomas Yeo, Andrea Brancale, David A Fidock, Karl F Hoffmann

bioRxiv· April 2024

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Small Molecule Ligands of the BET-like Bromodomain, BRD3, Affect Survival, Oviposition, and Development.
Matthias Schiedel, Darius J B McArdle, Gilda Padalino, Anthony K N Chan, Josephine Forde-Thomas, Karl F Hoffmann

J Med Chem· December 2023

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Modified Hederagenin Derivatives Demonstrate Ex Vivo Anthelmintic Activity against .
Anand Chakroborty, Deiniol R Pritchard, Marc E Bouillon, Anna Cervi, Rolf Kraehenbuehl, Karl F Hoffmann

Pharmaceutics· July 2023

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Perspective on Schistosomiasis Drug Discovery: Highlights from a Schistosomiasis Drug Discovery Workshop at Wellcome Collection, London, September 2022.
Nicola Caldwell, Rana Afshar, Beatriz Baragaña, Amaya L Bustinduy, Conor R Caffrey, Karl F Hoffmann

ACS Infect Dis· May 2023

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Using ChEMBL to Complement Schistosome Drug Discovery.
Gilda Padalino, Avril Coghlan, Giampaolo Pagliuca, Josephine E Forde-Thomas, Matthew Berriman, Karl F Hoffmann

Pharmaceutics· April 2023

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Chemical modulation of lysine specific demethylase 1 (SmLSD1) induces wide-scale biological and epigenomic changes.
Gilda Padalino, Cassandra A Celatka, Hugh Y Rienhoff, Jay H Kalin, Philip A Cole, Karl F Hoffmann

Wellcome Open Res· March 2023

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Special considerations for studies of extracellular vesicles from parasitic helminths: A community-led roadmap to increase rigour and reproducibility.
Ruby White, Javier Sotillo, María Eugenia Ancarola, Anne Borup, Anders Toftegaard Boysen, Karl F Hoffmann

J Extracell Vesicles· January 2023

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Collective cell migration during optic cup formation features changing cell-matrix interactions linked to matrix topology.
Karen G Soans, Ana Patricia Ramos, Jaydeep Sidhaye, Abhijeet Krishna, Anastasia Solomatina, Karl B Hoffmann

Curr Biol· November 2022

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Flukicidal effects of abietane diterpenoid derived analogues against the food borne pathogen Fasciola hepatica.
Anand Chakroborty, Deiniol Pritchard, Marc E Bouillon, Anna Cervi, Alan Cookson, Karl F Hoffmann

Vet Parasitol· September 2022

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Identification of anti-schistosomal, anthelmintic and anti-parasitic compounds curated and text-mined from the scientific literature.
Avril Coghlan, Gilda Padalino, Noel M O'Boyle, Karl F Hoffmann, Matthew Berriman

Wellcome Open Res· July 2022

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Power-Optimal Control of a Stirling Engine's Frictional Piston Motion.
Raphael Paul, Abdellah Khodja, Andreas Fischer, Robin Masser, Karl Heinz Hoffmann

Entropy (Basel)· March 2022

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Schistosoma mansoni α-N-acetylgalactosaminidase (SmNAGAL) regulates coordinated parasite movement and egg production.
Benjamin J Hulme, Kathrin K Geyer, Josephine E Forde-Thomas, Gilda Padalino, Dylan W Phillips, Karl F Hoffmann

PLoS Pathog· January 2022

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Anti-schistosomal activities of quinoxaline-containing compounds: From hit identification to lead optimisation.
Gilda Padalino, Nelly El-Sakkary, Lawrence J Liu, Chenxi Liu, Danielle S G Harte, Karl F Hoffmann

Eur J Med Chem· December 2021

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Daily rhythms in gene expression of the human parasite Schistosoma mansoni.
Kate A Rawlinson, Adam J Reid, Zhigang Lu, Patrick Driguez, Anna Wawer, Karl F Hoffmann

BMC Biol· December 2021

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Schistosoma mansoni Larval Extracellular Vesicle protein 1 (SmLEV1) is an immunogenic antigen found in EVs released from pre-acetabular glands of invading cercariae.
Thomas A Gasan, Marije E Kuipers, Grisial H Roberts, Gilda Padalino, Josephine E Forde-Thomas, Karl F Hoffmann

PLoS Negl Trop Dis· November 2021

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Cooling Cycle Optimization for a Vuilleumier Refrigerator.
Raphael Paul, Abdellah Khodja, Andreas Fischer, Karl Heinz Hoffmann

Entropy (Basel)· November 2021

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First Experience of Three Neurovascular Centers With the p64MW-HPC, a Low-Profile Flow Diverter Designed for Proximal Cerebral Vessels With Antithrombotic Coating.
Helge Winters, Marie-Sophie Schüngel, Cordula Scherlach, Dirk Mucha, Jörg Thalwitzer, Karl Titus Hoffmann

Front Neurol· September 2021

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