Publications by authors named "Kent Gates"

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A Chemically Stable Interstrand Cross-Link Generated via a Reductive Amination Process Involving an Apurinic/Apyrimidinic Site and an Adenine Residue in Duplex DNA.
Tanhaul Islam, Nathan E Price, Saosan Binth Md Amin, Zhiyu Yang, Kevin M Johnson, Kent S Gates

Chem Res Toxicol· November 2025

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Nucleoside Reactions Shed Light on the Chemical Processes Underlying Interstrand Cross-Link Formation at Apurinic/Apyrimidinic Sites in Duplex DNA.
Garam Shim, Michael Catalano, Anuoluwapo Gomina, Tanhaul Islam, Kent S Gates

Chemistry· September 2025

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DNA Alkylation, Cross-Linking, and Cancer Cell Killing by a Quinoxaline--Mustard Conjugate.
Chandra Sova Mandi, Dipendu Patra, Tanhaul Islam, Bhim Majhi, Kent S Gates

ACS Chem Biol· June 2025

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Repurposing the Antihypertensive Agent Hydralazine As an Inhibitor of the Base Excision Repair Enzyme APE1.
Tanhaul Islam, Venkatrao Nunna, Don Pivithuru Liyanarachchi, Douglas Melton, Calvin D Lewis, Kent S Gates

Chem Res Toxicol· January 2025

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Noncovalent Inhibition and Covalent Inactivation of Proline Dehydrogenase by Analogs of -Propargylglycine.
John J Tanner, Juan Ji, Alexandra N Bogner, Gary K Scott, Sagar M Patel, Kent S Gates

Biochemistry· November 2024

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The Intercalator Ethidium Bromide Generates Covalent Adducts at Apurinic/Apyrimidinic Sites in DNA.
Tanhaul Islam, Saosan Binth Md Amin, Kent S Gates

Chem Res Toxicol· November 2024

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Ultrafast Reaction of the Drug Hydralazine with Apurinic/Apyrimidinic Sites in DNA Gives Rise to a Stable Triazolo[3,4-]phthalazine Adduct.
Tanhaul Islam, Garam Shim, Douglas Melton, Calvin D Lewis, Zhentian Lei, Kent S Gates

Chem Res Toxicol· June 2024

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Formation and Properties of DNA Adducts Generated by Reactions of Abasic Sites with 1,2-Aminothiols Including Cysteamine, Cysteine Methyl Ester, and Peptides Containing -Terminal Cysteine Residues.
Anuoluwapo Gomina, Tanhaul Islam, Garam Shim, Zhentian Lei, Kent S Gates

Chem Res Toxicol· February 2024

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Novel Processes Associated with the Repair of Interstrand Cross-Links Derived from Abasic Sites in Duplex DNA: Roles for the Base Excision Repair Glycosylase NEIL3 and the SRAP Protein HMCES.
Nathan E Price, Kent S Gates

Chem Res Toxicol· February 2024

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-Methyl--nitrosourea Induced 3'-Glutathionylated DNA-Cleavage Products in Mammalian Cells.
Jiekai Yin, Kent S Gates, Yinsheng Wang

Anal Chem· November 2022

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Effects of Local Sequence, Reaction Conditions, and Various Additives on the Formation and Stability of Interstrand Cross-Links Derived from the Reaction of an Abasic Site with an Adenine Residue in Duplex DNA.
Saosan Binth Md Amin, Tanhaul Islam, Nathan E Price, Amanda Wallace, Xu Guo, Kent S Gates

ACS Omega· October 2022

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Reconsidering the Chemical Nature of Strand Breaks Derived from Abasic Sites in Cellular DNA: Evidence for 3'-Glutathionylation.
Jay S Jha, Jiekai Yin, Tuhin Haldar, Zhiyu Yang, Yinsheng Wang, Kent S Gates

J Am Chem Soc· June 2022

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Products Generated by Amine-Catalyzed Strand Cleavage at Apurinic/Apyrimidinic Sites in DNA: New Insights from a Biomimetic Nucleoside Model System.
Jay S Jha, Christopher Nel, Tuhin Haldar, Daniel Peters, Kurt Housh, Kent S Gates

Chem Res Toxicol· February 2022

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Unexpected Complexity in the Products Arising from NaOH-, Heat-, Amine-, and Glycosylase-Induced Strand Cleavage at an Abasic Site in DNA.
Tuhin Haldar, Jay S Jha, Zhiyu Yang, Christopher Nel, Kurt Housh, Kent S Gates

Chem Res Toxicol· February 2022

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Photoinduced Covalent Irreversible Inactivation of Proline Dehydrogenase by S-Heterocycles.
Ashley C Campbell, Austin R Prater, Alexandra N Bogner, Thomas P Quinn, Kent S Gates

ACS Chem Biol· November 2021

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Synthesis of DNA Duplexes Containing Site-Specific Interstrand Cross-Links via Sequential Reductive Amination Reactions Involving Diamine Linkers and Abasic Sites on Complementary Oligodeoxynucleotides.
Kurt Housh, Kent S Gates

Chem Res Toxicol· November 2021

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Formation and Repair of an Interstrand DNA Cross-Link Arising from a Common Endogenous Lesion.
Kurt Housh, Jay S Jha, Zhiyu Yang, Tuhin Haldar, Kevin M Johnson, Kent S Gates

J Am Chem Soc· September 2021

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Interstrand Cross-Link Formation Involving Reaction of a Mispaired Cytosine Residue with an Abasic Site in Duplex DNA.
Jacqueline Gamboa Varela, Luke E Pierce, Xu Guo, Nathan E Price, Kevin M Johnson, Kent S Gates

Chem Res Toxicol· April 2021

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Formation and repair of unavoidable, endogenous interstrand cross-links in cellular DNA.
Kurt Housh, Jay S Jha, Tuhin Haldar, Saosan Binth Md Amin, Tanhaul Islam, Kent S Gates

DNA Repair (Amst)· February 2021

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Structure of a Stable Interstrand DNA Cross-Link Involving a β--Glycosyl Linkage Between an -dA Amino Group and an Abasic Site.
Andrew H Kellum, David Y Qiu, Markus W Voehler, William Martin, Kent S Gates

Biochemistry· January 2021

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An autoinhibitory role for the GRF zinc finger domain of DNA glycosylase NEIL3.
Alyssa A Rodriguez, Jessica L Wojtaszek, Briana H Greer, Tuhin Haldar, Kent S Gates

J Biol Chem· November 2020

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Inhibition, crystal structures, and in-solution oligomeric structure of aldehyde dehydrogenase 9A1.
Jesse W Wyatt, David A Korasick, Insaf A Qureshi, Ashley C Campbell, Kent S Gates

Arch Biochem Biophys· September 2020

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Structural analysis of pathogenic mutations targeting Glu427 of ALDH7A1, the hot spot residue of pyridoxine-dependent epilepsy.
Adrian R Laciak, David A Korasick, Kent S Gates, John J Tanner

J Inherit Metab Dis· May 2020

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Covalent Modification of the Flavin in Proline Dehydrogenase by Thiazolidine-2-Carboxylate.
Ashley C Campbell, Donald F Becker, Kent S Gates, John J Tanner

ACS Chem Biol· April 2020

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Unhooking of an interstrand cross-link at DNA fork structures by the DNA glycosylase NEIL3.
Maryam Imani Nejad, Kurt Housh, Alyssa A Rodriguez, Tuhin Haldar, Scott Kathe, Kent S Gates

DNA Repair (Amst)· February 2020

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