Publications by authors named "Khalid El-Sayed"

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The Olive Phenolic -(-)-Oleocanthal as a Novel Intervention for Neuroendocrine Prostate Cancers: Therapeutic and Molecular Insights.
Md Towhidul Islam Tarun, Hassan Y Ebrahim, Dalal Dawud, Zakaria Y Abd Elmageed, Eva Corey

Nutrients· December 2025

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Demethylmycemycin A, a dibenzoxazepinone from the marine-derived Dactylosporangium sp. OK1079, with prostate cancer suppressive effects via targeting BRK-FAK-STAT3 axis.
Marwa Elsbaey, Md Towhidul Islam Tarun, Radwan Alnajjar, Takahiro Jomori, Junichi Tanaka

J Antibiot (Tokyo)· November 2025

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Safety, Pharmacokinetics, Translational and Molecular Mechanistic Insights on the Prostate Cancer Recurrence Suppressor Pseurotin A.
Oliver C McGehee, Hassan Y Ebrahim, Sharon Meyer, Nehal A Ahmed, Chandra Mohan Reddy Muthumula

Molecules· October 2025

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Harnessing Nature's Chemistry: Deciphering Olive Oil Phenolics for the Control of Invasive Breast Carcinoma.
Nehal A Ahmed, Abu Bakar Siddique, Afsana Tajmim, Judy Ann King, Khalid A El Sayed

Molecules· July 2025

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(-)-Oleuropein as a Novel Metastatic Castration-Resistant Prostate Cancer Progression and Recurrence Suppressor via Targeting PCSK9-LDLR Axis.
Nehal A Ahmed, Mohamed M Mohyeldin, Hassan Y Ebrahim, Oliver C McGehee, Md Towhidul Islam Tarun

Nutrients· April 2025

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The Olive Oil Monophenolic Secoiridoid Ligstroside Aglycone Suppresses Melanoma Progression by Targeting the BRAF Signaling Pathway.
Md Ashiq Mahmud, Abu Bakar Siddique, Afsana Tajmim, Judy Ann King, Khalid A El Sayed

Molecules· January 2025

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The Olive Oil Phenolic -(-)-Oleocanthal Suppresses Colorectal Cancer Progression and Recurrence by Modulating SMYD2-EZH2 and c-MET Activation.
Md Towhidul Islam Tarun, Heba E Elsayed, Hassan Y Ebrahim, Khalid A El Sayed

Nutrients· January 2025

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Cannabidiol Suppresses Metastatic Castration-Resistant Prostate Cancer Progression and Recurrence through Modulating Tryptophan Catabolism.
Ethar A Mudhish, Hassan Y Ebrahim, Iman E Helal, Abdullah T Alhowiriny, Khalid A El Sayed

ACS Pharmacol Transl Sci· December 2024

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Blockade of neutral sphingomyelinase 2 exerts antitumor effect on metastatic castration resistant prostate cancer cells and promotes tumor regression when combined with Enzalutamide.
Shams Ge Shams, Dalal Dawud, Kasia Michalak, Maysoon M Makhlouf, Ahmed Moustafa

Am J Cancer Res· December 2024

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The Usnic Acid Analogue 4-FPBUA Enhances the Blood-Brain Barrier Function and Induces Autophagy in Alzheimer's Disease Mouse Models.
Sweilem B Al Rihani, Khaled H Elfakhri, Hassan Y Ebrahim, Nour F Al-Ghraiybah, Amer E Alkhalifa

ACS Chem Neurosci· September 2024

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Pseurotin A Validation as a Metastatic Castration-Resistant Prostate Cancer Recurrence-Suppressing Lead via PCSK9-LDLR Axis Modulation.
Khaldoun S Abdelwahed, Abu Bakar Siddique, Hassan Y Ebrahim, Mohammed H Qusa, Ethar A Mudhish

Mar Drugs· March 2023

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Towards Developing Novel Prostate Cancer Recurrence Suppressors: Acute Toxicity of Pseurotin A, an Orally Active PCSK9 Axis-Targeting Small-Molecule in Swiss Albino Mice.
Oliver C McGehee, Hassan Y Ebrahim, Ashkan H Rad, Khaldoun S Abdelwahed, Ethar A Mudhish

Molecules· February 2023

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-(-)-Oleocanthal Ex Vivo Modulatory Effects on Gut Microbiota.
Mohammed H Qusa, Khaldoun S Abdelwahed, Ronald A Hill, Khalid A El Sayed

Nutrients· January 2023

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Small extracellular vesicle-associated miR-6068 promotes aggressive phenotypes of prostate cancer through miR-6068/HIC2/SIRT1 axis.
Mohamed S A Gaballah, Hamdy E A Ali, Zeinab A Hassan, Shahenda Mahgoub, Hamid I Ali

Am J Cancer Res· August 2022

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Oleocanthal Attenuates Metastatic Castration-Resistant Prostate Cancer Progression and Recurrence by Targeting SMYD2.
Abu Bakar Siddique, Hassan Y Ebrahim, Afsana Tajmim, Judy Ann King, Khaldoun S Abdelwahed

Cancers (Basel)· July 2022

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The Tobacco β-Cembrenediol: A Prostate Cancer Recurrence Suppressor Lead and Prospective Scaffold via Modulation of Indoleamine 2,3-Dioxygenase and Tryptophan Dioxygenase.
Ethar A Mudhish, Abu Bakar Siddique, Hassan Y Ebrahim, Khaldoun S Abdelwahed, Judy Ann King

Nutrients· April 2022

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PCSK9 Axis-Targeting Pseurotin A as a Novel Prostate Cancer Recurrence Suppressor Lead.
Khaldoun S Abdelwahed, Abu Bakar Siddique, Mohammed H Qusa, Judy Ann King, Soumaya Souid

ACS Pharmacol Transl Sci· December 2021

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(-)-Oleocanthal Nutraceuticals for Alzheimer's Disease Amyloid Pathology: Novel Oral Formulations, Therapeutic, and Molecular Insights in 5xFAD Transgenic Mice Model.
Afsana Tajmim, Areli K Cuevas-Ocampo, Abu Bakar Siddique, Mohammed H Qusa, Judy Ann King

Nutrients· May 2021

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Comparative Gene Signature of (-)-Oleocanthal Formulation Treatments in Heterogeneous Triple Negative Breast Tumor Models: Oncological Therapeutic Target Insights.
Mohammed H Qusa, Khaldoun S Abdelwahed, Abu Bakar Siddique, Khalid A El Sayed

Nutrients· May 2021

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Spontaneous and Interaction of (-)-Oleocanthal with Glycine in Biological Fluids: Novel Pharmacokinetic Markers.
Lucy I Darakjian, Aimilia Rigakou, Andrew Brannen, Mohammed H Qusa, Niki Tasiakou

ACS Pharmacol Transl Sci· February 2021

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Correction: Triple-negative breast cancer suppressive activities, antioxidants and pharmacophore model of new acylated rhamnopyranoses from .
Abeer H Elmaidomy, Rabab Mohammed, Asmaa I Owis, Mona H Hetta, Asmaa M AboulMagd

RSC Adv· January 2021

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HER2 Kinase-Targeted Breast Cancer Therapy: Design, Synthesis, and and Evaluation of Novel Lapatinib Congeners as Selective and Potent HER2 Inhibitors with Favorable Metabolic Stability.
Tamer A Elwaie, Safinaz E Abbas, Enayat I Aly, Riham F George, Hamdy Ali

J Med Chem· December 2020

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Olive Oil Lignan (+)-Acetoxypinoresinol Peripheral Motor and Neuronal Protection against the Tremorgenic Mycotoxin Penitrem A Toxicity STAT1 Pathway.
Mohammed H Qusa, Khaldoun S Abdelwahed, Sharon A Meyer, Khalid A El Sayed

ACS Chem Neurosci· November 2020

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Pseurotin A as a novel suppressor of hormone dependent breast cancer progression and recurrence by inhibiting PCSK9 secretion and interaction with LDL receptor.
Khaldoun S Abdelwahed, Abu Bakar Siddique, Mohamed M Mohyeldin, Mohammed H Qusa, Amira A Goda

Pharmacol Res· August 2020

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Comment on López-Yerena et al. "Absorption and Intestinal Metabolic Profile of Oleocanthal in Rats" 2020, , 134.
Amal Kaddoumi, Khalid El Sayed

Pharmaceutics· July 2020

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