Publications by authors named "Kristin Hope"

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Very long chain fatty acid metabolism is required in acute myeloid leukemia.
Matthew Tcheng, Alessia Roma, Nawaz Ahmed, Richard W Smith, Preethi Jayanth, Mark D Minden, Aaron D Schimmer, David A Hess, Kristin Hope, Kevin A Rea

Blood· June 2021

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Plasma lipid levels predict chemotherapy response and survival in acute myeloid leukemia.
Cristiana O'Brien, Nirvana Nursimulu, Anit Tyagi, Rachel Culp-Hill, Andrea Arruda, Kristin Hope

Blood· November 2025

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Glutaredoxin 2 is essential for AML survival through mitochondrial permeability transition pore regulation.
Tianyi Ling, Cristiana O'Brien, Jonathan St-Germain, Vincent Rondeau, Mary Shi, Kristin Hope

Blood· November 2025

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Activation of a nongenetic AHR-ELMSAN1 axis optimizes BET-targeting therapy and suppresses leukemia stem cells in preclinical models.
Xinyue Zhou, Steven Moreira, Cecilia Restelli, Hong Wang, Soheil Jahangiri, Kristin J Hope

Sci Transl Med· August 2025

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Epigenetic regulation of noncanonical menin targets modulates menin inhibitor response in acute myeloid leukemia.
Xinyue Zhou, Lixia Zhang, Sajesan Aryal, Virginia Veasey, Amanda Tajik, Kristin J Hope

Blood· November 2024

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Spermidine metabolism regulates leukemia stem and progenitor cell function through KAT7 expression in patient-derived mouse models.
Vincent Rondeau, Jacob M Berman, Tianyi Ling, Cristiana O'Brien, Rachel Culp-Hill, Kristin J Hope

Sci Transl Med· September 2024

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RNA binding protein-directed control of leukemic stem cell evolution and function.
Pratik Joshi, Ava Keyvani Chahi, Lina Liu, Steven Moreira, Ana Vujovic, Kristin J Hope

Hemasphere· August 2024

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In Vivo Screening Unveils Pervasive RNA-Binding Protein Dependencies in Leukemic Stem Cells and Identifies ELAVL1 as a Therapeutic Target.
Ana Vujovic, Laura de Rooij, Ava Keyvani Chahi, He Tian Chen, Brian A Yee, Kristin J Hope

Blood Cancer Discov· May 2023

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Author Correction: Characterization of an RNA binding protein interactome reveals a context-specific post-transcriptional landscape of MYC-amplified medulloblastoma.
Michelle M Kameda-Smith, Helen Zhu, En-Ching Luo, Yujin Suk, Agata Xella, Kristin Hope

Nat Commun· January 2023

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Characterization of an RNA binding protein interactome reveals a context-specific post-transcriptional landscape of MYC-amplified medulloblastoma.
Michelle M Kameda-Smith, Helen Zhu, En-Ching Luo, Yujin Suk, Agata Xella, Kristin Hope

Nat Commun· December 2022

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Glutamine Metabolism Mediates Sensitivity to Respiratory Complex II Inhibition in Acute Myeloid Leukemia.
Alessia Roma, Matthew Tcheng, Nawaz Ahmed, Sarah Walker, Preethi Jayanth, Kristin Hope

Mol Cancer Res· November 2022

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PLAG1 dampens protein synthesis to promote human hematopoietic stem cell self-renewal.
Ava Keyvani Chahi, Muluken S Belew, Joshua Xu, He Tian Tony Chen, Stefan Rentas, Kristin J Hope

Blood· September 2022

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The splicing factor RBM17 drives leukemic stem cell maintenance by evading nonsense-mediated decay of pro-leukemic factors.
Lina Liu, Ana Vujovic, Nandan P Deshpande, Shashank Sathe, Govardhan Anande, Kristin J Hope

Nat Commun· July 2022

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Oncogenic ZMYND11-MBTD1 fusion protein anchors the NuA4/TIP60 histone acetyltransferase complex to the coding region of active genes.
Maëva Devoucoux, Victoire Fort, Gabriel Khelifi, Joshua Xu, Nader Alerasool, Kristin Hope

Cell Rep· June 2022

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Temporal profiling of therapy resistance in human medulloblastoma identifies novel targetable drivers of recurrence.
David Bakhshinyan, Ashley A Adile, Jeff Liu, William D Gwynne, Yujin Suk, Kristin Hope

Sci Adv· December 2021

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Arhgef2 regulates mitotic spindle orientation in hematopoietic stem cells and is essential for productive hematopoiesis.
Derek C H Chan, Joshua Xu, Ana Vujovic, Nicholas Wong, Victor Gordon, Kristin J Hope

Blood Adv· August 2021

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Assessing the Safety of a Cell-Based Immunotherapy for Brain Cancers Using a Humanized Model of Hematopoiesis.
Sabra K Salim, Joshua Xu, Nicholas Wong, Chitra Venugopal, Kristin J Hope

STAR Protoc· December 2020

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Making a bet on RET for hematopoietic stem cell expansion.
Kristin J Hope

Blood· November 2020

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Hematopoiesis in High Definition: Combining State and Fate Mapping.
Ava Keyvani Chahi, Kristin J Hope

Cell Stem Cell· September 2020

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The Rational Development of CD133-Targeting Immunotherapies for Glioblastoma.
Parvez Vora, Chitra Venugopal, Sabra Khalid Salim, Nazanin Tatari, David Bakhshinyan, Kristin Hope

Cell Stem Cell· June 2020

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Diminished AHR Signaling Drives Human Acute Myeloid Leukemia Stem Cell Maintenance.
Michelle Ly, Stefan Rentas, Ana Vujovic, Nicholas Wong, Steven Moreira, Kristin J Hope

Cancer Res· November 2019

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Aberrant Clonal Hematopoiesis following Lentiviral Vector Transduction of HSPCs in a Rhesus Macaque.
Diego A Espinoza, Xing Fan, Di Yang, Stefan F Cordes, Lauren L Truitt, Kristin J Hope

Mol Ther· June 2019

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Post-transcriptional regulation in hematopoiesis: RNA binding proteins take control .
Laura P M H de Rooij, Derek C H Chan, Ava Keyvani Chahi, Kristin J Hope

Biochem Cell Biol· February 2019

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PLAG1 and USF2 Co-regulate Expression of Musashi-2 in Human Hematopoietic Stem and Progenitor Cells.
Muluken S Belew, Sonam Bhatia, Ava Keyvani Chahi, Stefan Rentas, Jonathan S Draper, Kristin J Hope

Stem Cell Reports· April 2018

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OTUD7A Regulates Neurodevelopmental Phenotypes in the 15q13.3 Microdeletion Syndrome.
Mohammed Uddin, Brianna K Unda, Vickie Kwan, Nicholas T Holzapfel, Sean H White, Kristin J Hope

Am J Hum Genet· February 2018

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